At the Start of the Sarcomere: A Previously Unrecognized Role for Myosin Chaperones and Associated Proteins during Early Myofibrillogenesis
The development of striated muscle in vertebrates requires the assembly of contractile myofibrils, consisting of highly ordered bundles of protein filaments. Myofibril formation occurs by the stepwise addition of complex proteins, a process that is mediated by a variety of molecular chaperones and q...
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| Format: | Article |
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Wiley
2012-01-01
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| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2012/712315 |
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| author | J. Layne Myhre David B. Pilgrim |
| author_facet | J. Layne Myhre David B. Pilgrim |
| author_sort | J. Layne Myhre |
| collection | DOAJ |
| description | The development of striated muscle in vertebrates requires the assembly of contractile myofibrils, consisting of highly ordered bundles of protein filaments. Myofibril formation occurs by the stepwise addition of complex proteins, a process that is mediated by a variety of molecular chaperones and quality control factors. Most notably, myosin of the thick filament requires specialized chaperone activity during late myofibrillogenesis, including that of Hsp90 and its cofactor, Unc45b. Unc45b has been proposed to act exclusively as an adaptor molecule, stabilizing interactions between Hsp90 and myosin; however, recent discoveries in zebrafish and C. elegans suggest the possibility of an earlier role for Unc45b during myofibrillogenesis. This role may involve functional control of nonmuscle myosins during the earliest stages of myogenesis, when premyofibril scaffolds are first formed from dynamic cytoskeletal actin. This paper will outline several lines of evidence that converge to build a model for Unc45b activity during early myofibrillogenesis. |
| format | Article |
| id | doaj-art-2a9962fbda0a40798a8d44359ed9cf13 |
| institution | Kabale University |
| issn | 2090-2247 2090-2255 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
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| series | Biochemistry Research International |
| spelling | doaj-art-2a9962fbda0a40798a8d44359ed9cf132025-02-03T01:04:43ZengWileyBiochemistry Research International2090-22472090-22552012-01-01201210.1155/2012/712315712315At the Start of the Sarcomere: A Previously Unrecognized Role for Myosin Chaperones and Associated Proteins during Early MyofibrillogenesisJ. Layne Myhre0David B. Pilgrim1Department of Biological Sciences, CW405, Biological Sciences Building, University of Alberta, Edmonton, AB, T6G 2E9, CanadaDepartment of Biological Sciences, CW405, Biological Sciences Building, University of Alberta, Edmonton, AB, T6G 2E9, CanadaThe development of striated muscle in vertebrates requires the assembly of contractile myofibrils, consisting of highly ordered bundles of protein filaments. Myofibril formation occurs by the stepwise addition of complex proteins, a process that is mediated by a variety of molecular chaperones and quality control factors. Most notably, myosin of the thick filament requires specialized chaperone activity during late myofibrillogenesis, including that of Hsp90 and its cofactor, Unc45b. Unc45b has been proposed to act exclusively as an adaptor molecule, stabilizing interactions between Hsp90 and myosin; however, recent discoveries in zebrafish and C. elegans suggest the possibility of an earlier role for Unc45b during myofibrillogenesis. This role may involve functional control of nonmuscle myosins during the earliest stages of myogenesis, when premyofibril scaffolds are first formed from dynamic cytoskeletal actin. This paper will outline several lines of evidence that converge to build a model for Unc45b activity during early myofibrillogenesis.http://dx.doi.org/10.1155/2012/712315 |
| spellingShingle | J. Layne Myhre David B. Pilgrim At the Start of the Sarcomere: A Previously Unrecognized Role for Myosin Chaperones and Associated Proteins during Early Myofibrillogenesis Biochemistry Research International |
| title | At the Start of the Sarcomere: A Previously Unrecognized Role for Myosin Chaperones and Associated Proteins during Early Myofibrillogenesis |
| title_full | At the Start of the Sarcomere: A Previously Unrecognized Role for Myosin Chaperones and Associated Proteins during Early Myofibrillogenesis |
| title_fullStr | At the Start of the Sarcomere: A Previously Unrecognized Role for Myosin Chaperones and Associated Proteins during Early Myofibrillogenesis |
| title_full_unstemmed | At the Start of the Sarcomere: A Previously Unrecognized Role for Myosin Chaperones and Associated Proteins during Early Myofibrillogenesis |
| title_short | At the Start of the Sarcomere: A Previously Unrecognized Role for Myosin Chaperones and Associated Proteins during Early Myofibrillogenesis |
| title_sort | at the start of the sarcomere a previously unrecognized role for myosin chaperones and associated proteins during early myofibrillogenesis |
| url | http://dx.doi.org/10.1155/2012/712315 |
| work_keys_str_mv | AT jlaynemyhre atthestartofthesarcomereapreviouslyunrecognizedroleformyosinchaperonesandassociatedproteinsduringearlymyofibrillogenesis AT davidbpilgrim atthestartofthesarcomereapreviouslyunrecognizedroleformyosinchaperonesandassociatedproteinsduringearlymyofibrillogenesis |