Evolution of Collagenous Colitis into Severe and Extensive Ulcerative Colitis
Collagenous colitis is an inflammatory mucosal disorder of the colon with distinctive histopathological features, including a thickened subepithelial collagen layer. The clinical course is usually benign, but serious complications, including death, may occur. In the present report, a 69-year-old wom...
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2007/950154 |
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| _version_ | 1832547491466182656 |
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| author | Hugh J Freeman Ken W Berean Michael Nimmo |
| author_facet | Hugh J Freeman Ken W Berean Michael Nimmo |
| author_sort | Hugh J Freeman |
| collection | DOAJ |
| description | Collagenous colitis is an inflammatory mucosal disorder of the colon with distinctive histopathological features, including a thickened subepithelial collagen layer. The clinical course is usually benign, but serious complications, including death, may occur. In the present report, a 69-year-old woman with watery diarrhea and collagenous colitis developed bloody diarrhea that was refractory to treatment medications, including corticosteroids and azathioprine. Endoscopic and histopathological studies showed a focal neutrophilic inflammatory process that progressed to a diffuse and extensive form of colitis, eventually requiring total proctocolectomy. Careful histological review of the resected colon showed no evidence of persistent collagenous colitis. These findings suggest an important need for continued long-term follow-up of patients with collagenous colitis because superimposed and serious colonic complications may occur, including a severe and extensive pancolitis refractory to medications and necessitating total proctocolectomy. |
| format | Article |
| id | doaj-art-2a8a73e4e70844f18a33d684f0757910 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-2a8a73e4e70844f18a33d684f07579102025-02-03T06:44:32ZengWileyCanadian Journal of Gastroenterology0835-79002007-01-0121531531810.1155/2007/950154Evolution of Collagenous Colitis into Severe and Extensive Ulcerative ColitisHugh J Freeman0Ken W Berean1Michael Nimmo2Division of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, CanadaDepartment of Pathology, University of British Columbia, Vancouver, British Columbia, CanadaDepartment of Pathology, University of British Columbia, Vancouver, British Columbia, CanadaCollagenous colitis is an inflammatory mucosal disorder of the colon with distinctive histopathological features, including a thickened subepithelial collagen layer. The clinical course is usually benign, but serious complications, including death, may occur. In the present report, a 69-year-old woman with watery diarrhea and collagenous colitis developed bloody diarrhea that was refractory to treatment medications, including corticosteroids and azathioprine. Endoscopic and histopathological studies showed a focal neutrophilic inflammatory process that progressed to a diffuse and extensive form of colitis, eventually requiring total proctocolectomy. Careful histological review of the resected colon showed no evidence of persistent collagenous colitis. These findings suggest an important need for continued long-term follow-up of patients with collagenous colitis because superimposed and serious colonic complications may occur, including a severe and extensive pancolitis refractory to medications and necessitating total proctocolectomy.http://dx.doi.org/10.1155/2007/950154 |
| spellingShingle | Hugh J Freeman Ken W Berean Michael Nimmo Evolution of Collagenous Colitis into Severe and Extensive Ulcerative Colitis Canadian Journal of Gastroenterology |
| title | Evolution of Collagenous Colitis into Severe and Extensive Ulcerative Colitis |
| title_full | Evolution of Collagenous Colitis into Severe and Extensive Ulcerative Colitis |
| title_fullStr | Evolution of Collagenous Colitis into Severe and Extensive Ulcerative Colitis |
| title_full_unstemmed | Evolution of Collagenous Colitis into Severe and Extensive Ulcerative Colitis |
| title_short | Evolution of Collagenous Colitis into Severe and Extensive Ulcerative Colitis |
| title_sort | evolution of collagenous colitis into severe and extensive ulcerative colitis |
| url | http://dx.doi.org/10.1155/2007/950154 |
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