The ratio of chloride to bicarbonate is a predictor of advanced metabolic acidosis in CKD stages G4 and G5

The ratio of chloride to bicarbonate is a predictor of advanced metabolic acidosis in CKD stages G4 and G5

Abstract Metabolic acidosis is a common disorder in patients with chronic kidney disease (CKD). As eGFR decreases, a reciprocal decrease in bicarbonate (HCO3 −) and an increase in chloride (Cl−) concentration is observed. The aim of this study is to determine whether the Cl−/HCO3 − ratio can be used...

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Main Authors: Justyna Korus, Maciej Gołębiowski, Jakub Stojanowski, Maciej Szymczak, Marcelina Żabińska, Dorota Bartoszek, Katarzyna Kościelska-Kasprzak, Mirosław Banasik, Milena Ściskalska, Mariusz Kusztal, Tomasz Gołębiowski
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Metabolic acidosis
Bicarbonate, chloride, anion gap
CKD
Online Access:https://doi.org/10.1038/s41598-025-05633-6
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