Altered Daytime Fluctuation Pattern of Plasminogen Activator Inhibitor 1 in Type 2 Diabetes Patients with Coronary Artery Disease: A Strong Association with Persistently Elevated Plasma Insulin, Increased Insulin Resistance, and Abdominal Obesity
This study was aimed at investigating daily fluctuation of PAI-1 levels in relation to insulin resistance (IR) and daily profile of plasma insulin and glucose levels in 26 type 2 diabetic (T2D) patients with coronary artery disease (CAD) (group A), 10 T2D patients without CAD (group B), 12 nondiabet...
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| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/390185 |
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| author | Katarina Lalić Aleksandra Jotić Nataša Rajković Sandra Singh Ljubica Stošić Ljiljana Popović Ljiljana Lukić Tanja Miličić Jelena P. Seferović Marija Maćešić Jelena Stanarčić Milorad Čivčić Iva Kadić Nebojša M. Lalić |
| author_facet | Katarina Lalić Aleksandra Jotić Nataša Rajković Sandra Singh Ljubica Stošić Ljiljana Popović Ljiljana Lukić Tanja Miličić Jelena P. Seferović Marija Maćešić Jelena Stanarčić Milorad Čivčić Iva Kadić Nebojša M. Lalić |
| author_sort | Katarina Lalić |
| collection | DOAJ |
| description | This study was aimed at investigating daily fluctuation of PAI-1 levels in relation to insulin resistance (IR) and daily profile of plasma insulin and glucose levels in 26 type 2 diabetic (T2D) patients with coronary artery disease (CAD) (group A), 10 T2D patients without CAD (group B), 12 nondiabetics with CAD (group C), and 12 healthy controls (group D). The percentage of PAI-1 decrease was lower in group A versus group B (4.4 ± 2.7 versus 35.0 ± 5.4%; P<0.05) and in C versus D (14.0 ± 5.8 versus 44.7 ± 3.1%; P<0.001). HOMA-IR was higher in group A versus group B (P<0.05) and in C versus D (P<0.01). Simultaneously, AUCs of PAI-1 and insulin were higher in group A versus group B (P<0.05) and in C versus D (P<0.01), while AUC of glucose did not differ between groups. In multiple regression analysis waist-to-hip ratio and AUC of insulin were independent determinants of decrease in PAI-1. The altered diurnal fluctuation of PAI-1, especially in T2D with CAD, might be strongly influenced by a prolonged exposure to hyperinsulinemia in the settings of increased IR and abdominal obesity, facilitating altogether an accelerated atherosclerosis. |
| format | Article |
| id | doaj-art-2a88052a2bbf4696bf48697ed67b947e |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-2a88052a2bbf4696bf48697ed67b947e2025-02-03T05:50:20ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/390185390185Altered Daytime Fluctuation Pattern of Plasminogen Activator Inhibitor 1 in Type 2 Diabetes Patients with Coronary Artery Disease: A Strong Association with Persistently Elevated Plasma Insulin, Increased Insulin Resistance, and Abdominal ObesityKatarina Lalić0Aleksandra Jotić1Nataša Rajković2Sandra Singh3Ljubica Stošić4Ljiljana Popović5Ljiljana Lukić6Tanja Miličić7Jelena P. Seferović8Marija Maćešić9Jelena Stanarčić10Milorad Čivčić11Iva Kadić12Nebojša M. Lalić13Clinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Dr. Subotica 13, 11000 Belgrade, SerbiaClinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Dr. Subotica 13, 11000 Belgrade, SerbiaClinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Dr. Subotica 13, 11000 Belgrade, SerbiaClinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Dr. Subotica 13, 11000 Belgrade, SerbiaClinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Dr. Subotica 13, 11000 Belgrade, SerbiaClinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Dr. Subotica 13, 11000 Belgrade, SerbiaClinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Dr. Subotica 13, 11000 Belgrade, SerbiaClinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Dr. Subotica 13, 11000 Belgrade, SerbiaClinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Dr. Subotica 13, 11000 Belgrade, SerbiaClinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Dr. Subotica 13, 11000 Belgrade, SerbiaClinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Dr. Subotica 13, 11000 Belgrade, SerbiaClinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Dr. Subotica 13, 11000 Belgrade, SerbiaClinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Dr. Subotica 13, 11000 Belgrade, SerbiaClinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Dr. Subotica 13, 11000 Belgrade, SerbiaThis study was aimed at investigating daily fluctuation of PAI-1 levels in relation to insulin resistance (IR) and daily profile of plasma insulin and glucose levels in 26 type 2 diabetic (T2D) patients with coronary artery disease (CAD) (group A), 10 T2D patients without CAD (group B), 12 nondiabetics with CAD (group C), and 12 healthy controls (group D). The percentage of PAI-1 decrease was lower in group A versus group B (4.4 ± 2.7 versus 35.0 ± 5.4%; P<0.05) and in C versus D (14.0 ± 5.8 versus 44.7 ± 3.1%; P<0.001). HOMA-IR was higher in group A versus group B (P<0.05) and in C versus D (P<0.01). Simultaneously, AUCs of PAI-1 and insulin were higher in group A versus group B (P<0.05) and in C versus D (P<0.01), while AUC of glucose did not differ between groups. In multiple regression analysis waist-to-hip ratio and AUC of insulin were independent determinants of decrease in PAI-1. The altered diurnal fluctuation of PAI-1, especially in T2D with CAD, might be strongly influenced by a prolonged exposure to hyperinsulinemia in the settings of increased IR and abdominal obesity, facilitating altogether an accelerated atherosclerosis.http://dx.doi.org/10.1155/2015/390185 |
| spellingShingle | Katarina Lalić Aleksandra Jotić Nataša Rajković Sandra Singh Ljubica Stošić Ljiljana Popović Ljiljana Lukić Tanja Miličić Jelena P. Seferović Marija Maćešić Jelena Stanarčić Milorad Čivčić Iva Kadić Nebojša M. Lalić Altered Daytime Fluctuation Pattern of Plasminogen Activator Inhibitor 1 in Type 2 Diabetes Patients with Coronary Artery Disease: A Strong Association with Persistently Elevated Plasma Insulin, Increased Insulin Resistance, and Abdominal Obesity International Journal of Endocrinology |
| title | Altered Daytime Fluctuation Pattern of Plasminogen Activator Inhibitor 1 in Type 2 Diabetes Patients with Coronary Artery Disease: A Strong Association with Persistently Elevated Plasma Insulin, Increased Insulin Resistance, and Abdominal Obesity |
| title_full | Altered Daytime Fluctuation Pattern of Plasminogen Activator Inhibitor 1 in Type 2 Diabetes Patients with Coronary Artery Disease: A Strong Association with Persistently Elevated Plasma Insulin, Increased Insulin Resistance, and Abdominal Obesity |
| title_fullStr | Altered Daytime Fluctuation Pattern of Plasminogen Activator Inhibitor 1 in Type 2 Diabetes Patients with Coronary Artery Disease: A Strong Association with Persistently Elevated Plasma Insulin, Increased Insulin Resistance, and Abdominal Obesity |
| title_full_unstemmed | Altered Daytime Fluctuation Pattern of Plasminogen Activator Inhibitor 1 in Type 2 Diabetes Patients with Coronary Artery Disease: A Strong Association with Persistently Elevated Plasma Insulin, Increased Insulin Resistance, and Abdominal Obesity |
| title_short | Altered Daytime Fluctuation Pattern of Plasminogen Activator Inhibitor 1 in Type 2 Diabetes Patients with Coronary Artery Disease: A Strong Association with Persistently Elevated Plasma Insulin, Increased Insulin Resistance, and Abdominal Obesity |
| title_sort | altered daytime fluctuation pattern of plasminogen activator inhibitor 1 in type 2 diabetes patients with coronary artery disease a strong association with persistently elevated plasma insulin increased insulin resistance and abdominal obesity |
| url | http://dx.doi.org/10.1155/2015/390185 |
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