Influence of preoperative variables on the 3-month functional outcomes of the Vivity extended depth-of-focus intraocular lens: a prospective case series
Abstract Background To investigate the functional results of the AcrySof IQ Vivity (Alcon, Fort Worth, TX) extended depth-of-focus intraocular lens (EDoF-IOL) and explore correlations between the preoperative biometric parameters and the postoperative functional outcomes. Methods In a prospective, s...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-02-01
|
| Series: | Eye and Vision |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40662-024-00424-y |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832571986800279552 |
|---|---|
| author | Giacomo Savini Alice Galzignato Catarina P. Coutinho Jinhai Huang Yue Wu Piero Barboni João Mendanha Dias Filomena J. Ribeiro Domenico Schiano-Lomoriello |
| author_facet | Giacomo Savini Alice Galzignato Catarina P. Coutinho Jinhai Huang Yue Wu Piero Barboni João Mendanha Dias Filomena J. Ribeiro Domenico Schiano-Lomoriello |
| author_sort | Giacomo Savini |
| collection | DOAJ |
| description | Abstract Background To investigate the functional results of the AcrySof IQ Vivity (Alcon, Fort Worth, TX) extended depth-of-focus intraocular lens (EDoF-IOL) and explore correlations between the preoperative biometric parameters and the postoperative functional outcomes. Methods In a prospective, single-center, non-randomized study, axial length, keratometry, anterior chamber depth, scotopic and photopic pupil diameters, pupil decentration, corneal asphericity, corneal higher-order aberrations (HOAs), coma and spherical aberration were measured preoperatively. The EDoF-IOL was implanted bilaterally. Three months postoperatively, manifest refraction, monocular and binocular uncorrected and corrected visual acuity at 4 m, 66 cm and 40 cm, binocular defocus curve, binocular contrast sensitivity, halometry and Strehl ratio were measured. Visual disturbances and spectacle independence were assessed with McAlinden and IOLSAT questionnaires, respectively. Assuming a minimum Pearson r correlation coefficient between variables of 0.5 with a power of 80% and a P value less than 0.05, a minimum sample size of 29 (58 eyes) cases was required. Results Forty-three patients were enrolled. Binocular distance corrected visual acuity was lower than 0.1 logMAR for a defocus between + 1.0 and − 1.5 D. The mean values at 66 cm and 40 cm were − 0.07 ± 0.06 and 0.19 ± 0.13 logMAR, respectively. McAlinden’s questionnaire revealed mean scores close to zero for all questions. The IOLSAT questionnaire showed that spectacles were never used for distance and intermediate vision. Regression analysis did not disclose any significant correlation between the preoperatively measured variables and the postoperative outcomes, with a few exceptions: preoperative higher order corneal aberrations were correlated to halometry area (r2 = 0.2592, P = 0.0006) and the Q value to contrast sensitivity (r2 = 0.1717, P = 0.00574) under photopic conditions with glare at a spatial frequency of 18 cpd and without glare for all spatial frequencies (P < 0.01); it was also correlated to contrast sensitivity under mesopic conditions without glare at a spatial frequency of 12 cpd (r2 = 0.2311, P = 0.0011). Conclusions In healthy unoperated eyes, the visual outcomes for this EDoF-IOL are independent of most of the patients’ preoperative parameters. Attention should be paid to preoperative corneal aberrations and asphericity, which did not lead to visual disturbances, but may be potential sources of halo and reduced contrast sensitivity. |
| format | Article |
| id | doaj-art-2a76b0e64b684b57a9b81ff1127d701e |
| institution | Kabale University |
| issn | 2326-0254 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Eye and Vision |
| spelling | doaj-art-2a76b0e64b684b57a9b81ff1127d701e2025-02-02T12:09:01ZengBMCEye and Vision2326-02542025-02-0112111110.1186/s40662-024-00424-yInfluence of preoperative variables on the 3-month functional outcomes of the Vivity extended depth-of-focus intraocular lens: a prospective case seriesGiacomo Savini0Alice Galzignato1Catarina P. Coutinho2Jinhai Huang3Yue Wu4Piero Barboni5João Mendanha Dias6Filomena J. Ribeiro7Domenico Schiano-Lomoriello8I.R.C.C.S. - G.B. Bietti FoundationStudio Oculistico d’AzeglioStudio Oculistico d’AzeglioEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; NHC Key laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical SciencesEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; NHC Key laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical SciencesStudio Oculistico d’AzeglioGoLP/IPFN, Instituto Superior Técnico, Universidade de LisboaHospital da Luz LisboaI.R.C.C.S. - G.B. Bietti FoundationAbstract Background To investigate the functional results of the AcrySof IQ Vivity (Alcon, Fort Worth, TX) extended depth-of-focus intraocular lens (EDoF-IOL) and explore correlations between the preoperative biometric parameters and the postoperative functional outcomes. Methods In a prospective, single-center, non-randomized study, axial length, keratometry, anterior chamber depth, scotopic and photopic pupil diameters, pupil decentration, corneal asphericity, corneal higher-order aberrations (HOAs), coma and spherical aberration were measured preoperatively. The EDoF-IOL was implanted bilaterally. Three months postoperatively, manifest refraction, monocular and binocular uncorrected and corrected visual acuity at 4 m, 66 cm and 40 cm, binocular defocus curve, binocular contrast sensitivity, halometry and Strehl ratio were measured. Visual disturbances and spectacle independence were assessed with McAlinden and IOLSAT questionnaires, respectively. Assuming a minimum Pearson r correlation coefficient between variables of 0.5 with a power of 80% and a P value less than 0.05, a minimum sample size of 29 (58 eyes) cases was required. Results Forty-three patients were enrolled. Binocular distance corrected visual acuity was lower than 0.1 logMAR for a defocus between + 1.0 and − 1.5 D. The mean values at 66 cm and 40 cm were − 0.07 ± 0.06 and 0.19 ± 0.13 logMAR, respectively. McAlinden’s questionnaire revealed mean scores close to zero for all questions. The IOLSAT questionnaire showed that spectacles were never used for distance and intermediate vision. Regression analysis did not disclose any significant correlation between the preoperatively measured variables and the postoperative outcomes, with a few exceptions: preoperative higher order corneal aberrations were correlated to halometry area (r2 = 0.2592, P = 0.0006) and the Q value to contrast sensitivity (r2 = 0.1717, P = 0.00574) under photopic conditions with glare at a spatial frequency of 18 cpd and without glare for all spatial frequencies (P < 0.01); it was also correlated to contrast sensitivity under mesopic conditions without glare at a spatial frequency of 12 cpd (r2 = 0.2311, P = 0.0011). Conclusions In healthy unoperated eyes, the visual outcomes for this EDoF-IOL are independent of most of the patients’ preoperative parameters. Attention should be paid to preoperative corneal aberrations and asphericity, which did not lead to visual disturbances, but may be potential sources of halo and reduced contrast sensitivity.https://doi.org/10.1186/s40662-024-00424-yPresbyopiaIntraocular lensCataract |
| spellingShingle | Giacomo Savini Alice Galzignato Catarina P. Coutinho Jinhai Huang Yue Wu Piero Barboni João Mendanha Dias Filomena J. Ribeiro Domenico Schiano-Lomoriello Influence of preoperative variables on the 3-month functional outcomes of the Vivity extended depth-of-focus intraocular lens: a prospective case series Eye and Vision Presbyopia Intraocular lens Cataract |
| title | Influence of preoperative variables on the 3-month functional outcomes of the Vivity extended depth-of-focus intraocular lens: a prospective case series |
| title_full | Influence of preoperative variables on the 3-month functional outcomes of the Vivity extended depth-of-focus intraocular lens: a prospective case series |
| title_fullStr | Influence of preoperative variables on the 3-month functional outcomes of the Vivity extended depth-of-focus intraocular lens: a prospective case series |
| title_full_unstemmed | Influence of preoperative variables on the 3-month functional outcomes of the Vivity extended depth-of-focus intraocular lens: a prospective case series |
| title_short | Influence of preoperative variables on the 3-month functional outcomes of the Vivity extended depth-of-focus intraocular lens: a prospective case series |
| title_sort | influence of preoperative variables on the 3 month functional outcomes of the vivity extended depth of focus intraocular lens a prospective case series |
| topic | Presbyopia Intraocular lens Cataract |
| url | https://doi.org/10.1186/s40662-024-00424-y |
| work_keys_str_mv | AT giacomosavini influenceofpreoperativevariablesonthe3monthfunctionaloutcomesofthevivityextendeddepthoffocusintraocularlensaprospectivecaseseries AT alicegalzignato influenceofpreoperativevariablesonthe3monthfunctionaloutcomesofthevivityextendeddepthoffocusintraocularlensaprospectivecaseseries AT catarinapcoutinho influenceofpreoperativevariablesonthe3monthfunctionaloutcomesofthevivityextendeddepthoffocusintraocularlensaprospectivecaseseries AT jinhaihuang influenceofpreoperativevariablesonthe3monthfunctionaloutcomesofthevivityextendeddepthoffocusintraocularlensaprospectivecaseseries AT yuewu influenceofpreoperativevariablesonthe3monthfunctionaloutcomesofthevivityextendeddepthoffocusintraocularlensaprospectivecaseseries AT pierobarboni influenceofpreoperativevariablesonthe3monthfunctionaloutcomesofthevivityextendeddepthoffocusintraocularlensaprospectivecaseseries AT joaomendanhadias influenceofpreoperativevariablesonthe3monthfunctionaloutcomesofthevivityextendeddepthoffocusintraocularlensaprospectivecaseseries AT filomenajribeiro influenceofpreoperativevariablesonthe3monthfunctionaloutcomesofthevivityextendeddepthoffocusintraocularlensaprospectivecaseseries AT domenicoschianolomoriello influenceofpreoperativevariablesonthe3monthfunctionaloutcomesofthevivityextendeddepthoffocusintraocularlensaprospectivecaseseries |