Renal Transplantation Dramatically Reduces IgA Anti-beta-2-glycoprotein I Antibodies in Patients with Endstage Renal Disease
IgA anti-beta-2-glycoprotein I (aB2GPI) antibodies have been related to vascular pathology in the general population and mainly in hemodialyzed patients (prevalence 33%) in whom an elevated incidence of thrombosis and mortality is found. In this paper we have studied the presence of IgA aB2GPI antib...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/641962 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551029891137536 |
|---|---|
| author | Manuel Serrano Jose Angel Martínez-Flores Maria José Castro Florencio García David Lora Dolores Pérez Esther Gonzalez Estela Paz-Artal Jose M. Morales Antonio Serrano |
| author_facet | Manuel Serrano Jose Angel Martínez-Flores Maria José Castro Florencio García David Lora Dolores Pérez Esther Gonzalez Estela Paz-Artal Jose M. Morales Antonio Serrano |
| author_sort | Manuel Serrano |
| collection | DOAJ |
| description | IgA anti-beta-2-glycoprotein I (aB2GPI) antibodies have been related to vascular pathology in the general population and mainly in hemodialyzed patients (prevalence 33%) in whom an elevated incidence of thrombosis and mortality is found. In this paper we have studied the presence of IgA aB2GPI antibodies at pretransplant and their evolution after transplantation with a cross-sectional-based follow-up study of a cohort of 288 endstage renal disease (ESRD) patients treated with kidney transplantation. Pretransplant IgA aB2GPI levels were elevated 31.7±4.2 U/mL without differences in age or type of dialysis. Patients with different etiologies of ESRD showed higher levels of IgA aB2GPI than blood donors, except the groups of non-IgA glomerular disease and systemic erythematosus lupus, whose nonsignificant differences were observed. IgA aB2GPI antibodies dropped immediately after transplantation (10.7±1.0 U/mL, P<0.0001), coinciding with a high degree of immunosuppression, and remained significantly lower than that observed in pretransplant status. Prevalence of patients with elevated antibodies was also less in transplanted patients (8.9% versus 30.4%, P<0.0001). Among, positivity for IgA aB2GPI was higher than in patients who had received their first transplant that those were retransplanted. This finding could have important clinical implications and can suggest new therapeutic strategies in patients with IgA aB2GPI antibodies. |
| format | Article |
| id | doaj-art-2a76836699bb471aabd987352d3fddff |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-2a76836699bb471aabd987352d3fddff2025-02-03T06:05:06ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/641962641962Renal Transplantation Dramatically Reduces IgA Anti-beta-2-glycoprotein I Antibodies in Patients with Endstage Renal DiseaseManuel Serrano0Jose Angel Martínez-Flores1Maria José Castro2Florencio García3David Lora4Dolores Pérez5Esther Gonzalez6Estela Paz-Artal7Jose M. Morales8Antonio Serrano9Servicio de Nefrología, Instituto de Investigacion Hospital Universitario 12 de Octubre, Avenida Córdoba s/n, 28041 Madrid, SpainServicio de Inmunología, Instituto de Investigacion Hospital Universitario 12 de Octubre, Avenida Córdoba s/n, 28041 Madrid, SpainServicio de Inmunología, Instituto de Investigacion Hospital Universitario 12 de Octubre, Avenida Córdoba s/n, 28041 Madrid, SpainServicio de Nefrología, Instituto de Investigacion Hospital Universitario 12 de Octubre, Avenida Córdoba s/n, 28041 Madrid, SpainServicio de Epidemiología, Instituto de Investigacion Hospital Universitario 12 de Octubre, Avenida Córdoba s/n, 28041 Madrid, SpainServicio de Inmunología, Instituto de Investigacion Hospital Universitario 12 de Octubre, Avenida Córdoba s/n, 28041 Madrid, SpainServicio de Nefrología, Instituto de Investigacion Hospital Universitario 12 de Octubre, Avenida Córdoba s/n, 28041 Madrid, SpainServicio de Inmunología, Instituto de Investigacion Hospital Universitario 12 de Octubre, Avenida Córdoba s/n, 28041 Madrid, SpainServicio de Nefrología, Instituto de Investigacion Hospital Universitario 12 de Octubre, Avenida Córdoba s/n, 28041 Madrid, SpainServicio de Inmunología, Instituto de Investigacion Hospital Universitario 12 de Octubre, Avenida Córdoba s/n, 28041 Madrid, SpainIgA anti-beta-2-glycoprotein I (aB2GPI) antibodies have been related to vascular pathology in the general population and mainly in hemodialyzed patients (prevalence 33%) in whom an elevated incidence of thrombosis and mortality is found. In this paper we have studied the presence of IgA aB2GPI antibodies at pretransplant and their evolution after transplantation with a cross-sectional-based follow-up study of a cohort of 288 endstage renal disease (ESRD) patients treated with kidney transplantation. Pretransplant IgA aB2GPI levels were elevated 31.7±4.2 U/mL without differences in age or type of dialysis. Patients with different etiologies of ESRD showed higher levels of IgA aB2GPI than blood donors, except the groups of non-IgA glomerular disease and systemic erythematosus lupus, whose nonsignificant differences were observed. IgA aB2GPI antibodies dropped immediately after transplantation (10.7±1.0 U/mL, P<0.0001), coinciding with a high degree of immunosuppression, and remained significantly lower than that observed in pretransplant status. Prevalence of patients with elevated antibodies was also less in transplanted patients (8.9% versus 30.4%, P<0.0001). Among, positivity for IgA aB2GPI was higher than in patients who had received their first transplant that those were retransplanted. This finding could have important clinical implications and can suggest new therapeutic strategies in patients with IgA aB2GPI antibodies.http://dx.doi.org/10.1155/2014/641962 |
| spellingShingle | Manuel Serrano Jose Angel Martínez-Flores Maria José Castro Florencio García David Lora Dolores Pérez Esther Gonzalez Estela Paz-Artal Jose M. Morales Antonio Serrano Renal Transplantation Dramatically Reduces IgA Anti-beta-2-glycoprotein I Antibodies in Patients with Endstage Renal Disease Journal of Immunology Research |
| title | Renal Transplantation Dramatically Reduces IgA Anti-beta-2-glycoprotein I Antibodies in Patients with Endstage Renal Disease |
| title_full | Renal Transplantation Dramatically Reduces IgA Anti-beta-2-glycoprotein I Antibodies in Patients with Endstage Renal Disease |
| title_fullStr | Renal Transplantation Dramatically Reduces IgA Anti-beta-2-glycoprotein I Antibodies in Patients with Endstage Renal Disease |
| title_full_unstemmed | Renal Transplantation Dramatically Reduces IgA Anti-beta-2-glycoprotein I Antibodies in Patients with Endstage Renal Disease |
| title_short | Renal Transplantation Dramatically Reduces IgA Anti-beta-2-glycoprotein I Antibodies in Patients with Endstage Renal Disease |
| title_sort | renal transplantation dramatically reduces iga anti beta 2 glycoprotein i antibodies in patients with endstage renal disease |
| url | http://dx.doi.org/10.1155/2014/641962 |
| work_keys_str_mv | AT manuelserrano renaltransplantationdramaticallyreducesigaantibeta2glycoproteiniantibodiesinpatientswithendstagerenaldisease AT joseangelmartinezflores renaltransplantationdramaticallyreducesigaantibeta2glycoproteiniantibodiesinpatientswithendstagerenaldisease AT mariajosecastro renaltransplantationdramaticallyreducesigaantibeta2glycoproteiniantibodiesinpatientswithendstagerenaldisease AT florenciogarcia renaltransplantationdramaticallyreducesigaantibeta2glycoproteiniantibodiesinpatientswithendstagerenaldisease AT davidlora renaltransplantationdramaticallyreducesigaantibeta2glycoproteiniantibodiesinpatientswithendstagerenaldisease AT doloresperez renaltransplantationdramaticallyreducesigaantibeta2glycoproteiniantibodiesinpatientswithendstagerenaldisease AT esthergonzalez renaltransplantationdramaticallyreducesigaantibeta2glycoproteiniantibodiesinpatientswithendstagerenaldisease AT estelapazartal renaltransplantationdramaticallyreducesigaantibeta2glycoproteiniantibodiesinpatientswithendstagerenaldisease AT josemmorales renaltransplantationdramaticallyreducesigaantibeta2glycoproteiniantibodiesinpatientswithendstagerenaldisease AT antonioserrano renaltransplantationdramaticallyreducesigaantibeta2glycoproteiniantibodiesinpatientswithendstagerenaldisease |