Pharmacological Treatment of Presbyopia Using Pilocarpine 1.25% Eye Drops
Purpose: To assess the efficiency and safety of pilocarpine eye drop 1.25% analogue (IRPilo) in comparison with its original brand-name drug (Vuity). Methods: In this non-randomized comparative study, 75 patients with presbyopia aged 40 to 60 years were enrolled. The right eyes of these patients r...
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Knowledge E
2024-12-01
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| Series: | Journal of Ophthalmic & Vision Research |
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| Online Access: | https://knepublishing.com/index.php/JOVR/article/view/14578 |
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| author | Seyed Abolghasem Mousavi Zhale Rajavi Hamideh Sabbaghi Saeid Abdi Nafeeseh Montazerin Bahareh Kheiri Azadeh Haseli- Monfared Kourosh Sheibani Hemn Baghban Jaldian |
| author_facet | Seyed Abolghasem Mousavi Zhale Rajavi Hamideh Sabbaghi Saeid Abdi Nafeeseh Montazerin Bahareh Kheiri Azadeh Haseli- Monfared Kourosh Sheibani Hemn Baghban Jaldian |
| author_sort | Seyed Abolghasem Mousavi |
| collection | DOAJ |
| description |
Purpose: To assess the efficiency and safety of pilocarpine eye drop 1.25% analogue (IRPilo) in comparison with its original brand-name drug (Vuity).
Methods: In this non-randomized comparative study, 75 patients with presbyopia aged 40 to 60 years were enrolled. The right eyes of these patients received either IR-Pilo (n = 45) or Vuity (n = 30) and their contralateral eyes served as controls. Refractive errors, distance best-corrected visual acuity (BCVA), near vision, amplitude of accommodation, pupil size, and intraocular pressure (IOP) were measured before and 1 to 2 hours after instillation of the eye drop.
Results: The mean refractive error was stable, except for a small myopic shift in the Vuity group. There was no significant change in distance BCVA. Near vision improved significantly in both intervention groups (P < 0.001) with preference for IR-Pilo (4 vs 2.3). Furthermore, a higher amplitude of accommodation and pupil constriction occurred after instillation of both drops, with a higher effect associated with IR-Pilo. However, IOP did not change significantly post intervention.
Conclusion: IR-Pilo and Vuity eye drops had comparable results; both were effective and led to stable distance vision and improved near vision. Both ophthalmic drugs were safe and none of them were associated with significant adverse effects.
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| format | Article |
| id | doaj-art-2a63867d3ab84638b7da7b29e817528d |
| institution | Kabale University |
| issn | 2008-2010 2008-322X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Journal of Ophthalmic & Vision Research |
| spelling | doaj-art-2a63867d3ab84638b7da7b29e817528d2025-01-21T05:15:07ZengKnowledge EJournal of Ophthalmic & Vision Research2008-20102008-322X2024-12-0119410.18502/jovr.v19i4.14578Pharmacological Treatment of Presbyopia Using Pilocarpine 1.25% Eye DropsSeyed Abolghasem Mousavi 0Zhale Rajavi1Hamideh Sabbaghi2Saeid Abdi3Nafeeseh Montazerin4Bahareh Kheiri5Azadeh Haseli- Monfared6Kourosh Sheibani7Hemn Baghban Jaldian8Negah Aref Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranNegah Aref Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranOphthalmic Epidemiology Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Optometry, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, IranNegah Aref Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranOphthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, IranNegah Aref Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranBasir Eye Health Research Center, Tehran, IranDepartment of Optometry, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran Purpose: To assess the efficiency and safety of pilocarpine eye drop 1.25% analogue (IRPilo) in comparison with its original brand-name drug (Vuity). Methods: In this non-randomized comparative study, 75 patients with presbyopia aged 40 to 60 years were enrolled. The right eyes of these patients received either IR-Pilo (n = 45) or Vuity (n = 30) and their contralateral eyes served as controls. Refractive errors, distance best-corrected visual acuity (BCVA), near vision, amplitude of accommodation, pupil size, and intraocular pressure (IOP) were measured before and 1 to 2 hours after instillation of the eye drop. Results: The mean refractive error was stable, except for a small myopic shift in the Vuity group. There was no significant change in distance BCVA. Near vision improved significantly in both intervention groups (P < 0.001) with preference for IR-Pilo (4 vs 2.3). Furthermore, a higher amplitude of accommodation and pupil constriction occurred after instillation of both drops, with a higher effect associated with IR-Pilo. However, IOP did not change significantly post intervention. Conclusion: IR-Pilo and Vuity eye drops had comparable results; both were effective and led to stable distance vision and improved near vision. Both ophthalmic drugs were safe and none of them were associated with significant adverse effects. https://knepublishing.com/index.php/JOVR/article/view/14578AccommodationDistance VisionEye DropsNear VisionPresbyopia |
| spellingShingle | Seyed Abolghasem Mousavi Zhale Rajavi Hamideh Sabbaghi Saeid Abdi Nafeeseh Montazerin Bahareh Kheiri Azadeh Haseli- Monfared Kourosh Sheibani Hemn Baghban Jaldian Pharmacological Treatment of Presbyopia Using Pilocarpine 1.25% Eye Drops Journal of Ophthalmic & Vision Research Accommodation Distance Vision Eye Drops Near Vision Presbyopia |
| title | Pharmacological Treatment of Presbyopia Using Pilocarpine 1.25% Eye Drops |
| title_full | Pharmacological Treatment of Presbyopia Using Pilocarpine 1.25% Eye Drops |
| title_fullStr | Pharmacological Treatment of Presbyopia Using Pilocarpine 1.25% Eye Drops |
| title_full_unstemmed | Pharmacological Treatment of Presbyopia Using Pilocarpine 1.25% Eye Drops |
| title_short | Pharmacological Treatment of Presbyopia Using Pilocarpine 1.25% Eye Drops |
| title_sort | pharmacological treatment of presbyopia using pilocarpine 1 25 eye drops |
| topic | Accommodation Distance Vision Eye Drops Near Vision Presbyopia |
| url | https://knepublishing.com/index.php/JOVR/article/view/14578 |
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