EGFR-mediated local invasiveness and response to Cetuximab in head and neck cancer

EGFR-mediated local invasiveness and response to Cetuximab in head and neck cancer

Abstract Background Recurrent/metastatic head and neck squamous cell carcinoma (R/M-HNSCC) is a severe, frequently lethal condition. Oncogene addiction to epidermal growth factor receptor (EGFR) is a hallmark of HNSCC, but the clinical efficacy of EGFR-targeted therapies remains low. Understanding m...

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Main Authors: Jiefu Zhou, Min He, Qiong Zhao, Enxian Shi, Hairong Wang, Vaidehi Ponkshe, Jiahang Song, Zhengquan Wu, Dongmei Ji, Gisela Kranz, Anna Tscherne, Sabina Schwenk-Zieger, Nilofer Abdul Razak, Julia Hess, Claus Belka, Horst Zitzelsberger, Iordanis Ourailidis, Fabian Stögbauer, Melanie Boxberg, Jan Budczies, Christoph A. Reichel, Martin Canis, Philipp Baumeister, Hongxia Wang, Kristian Unger, Andreas Mock, Olivier Gires
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Molecular Cancer
Subjects:
Oncogene addiction
EGFR
R/M-HNSCC
Cetuximab
EMT
Local invasion
Online Access:https://doi.org/10.1186/s12943-025-02290-1
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