Establishment of THTT derivatives as potential antileishmanial and anti-inflammatory agents through in vitro and in silico investigations

Establishment of THTT derivatives as potential antileishmanial and anti-inflammatory agents through in vitro and in silico investigations

Abstract Cutaneous leishmaniasis, a neglected tropical disease (NTD) caused by Leishmania tropica, Leishmania major and other members of the same species, poses significant challenges in the public health sector, especially in developing countries. The limitations of current treatments, including to...

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Bibliographic Details
Main Authors: Sarah Sarwar, Rehana Masood, Huma Khan, Haleema Ali, Said Hassan, Ajaz Ahmad, Syed Sikandar Shah, Naveed Khan, Rasool Khan, Ho Soonmin, Nadeem Ullah, Nazif Ullah
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Anti
Inflammatory
Cytotoxicity
In vitro and in silico activity
Leishmania tropica
Public health
Online Access:https://doi.org/10.1038/s41598-025-12084-6
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