Epigenetic modifications are associated with mRNA and cytokine expression changes in chronic rhinosinusitis: a multiomics study from the United States

Epigenetic modifications are associated with mRNA and cytokine expression changes in chronic rhinosinusitis: a multiomics study from the United States

Objectives/hypothesisChronic rhinosinusitis (CRS) may be triggered by environmental insults. We hypothesized that CRS results from epigenetic modifications of host DNA from external insults, leading to downstream RNA/DNA gene expression changes and immuno-mechanical disruptions. We therefore perform...

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Bibliographic Details
Main Authors: Devyani Lal, Tripti Brar, Chantal McCabe, Erik Jessen, Nitish Kumar, Pedro Lança Gomes, Michael J. Marino, Amar Miglani, Hirohito Kita
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Allergy
Subjects:
epigenetics
chronic rhinosinusitis
transcriptomics
proteomics
multiomics
cytokines
Online Access:https://www.frontiersin.org/articles/10.3389/falgy.2025.1606255/full
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