deepTFBS: Improving within‐ and Cross‐Species Prediction of Transcription Factor Binding Using Deep Multi‐Task and Transfer Learning

deepTFBS: Improving within‐ and Cross‐Species Prediction of Transcription Factor Binding Using Deep Multi‐Task and Transfer Learning

Abstract The precise prediction of transcription factor binding sites (TFBSs) is crucial in understanding gene regulation. In this study, deepTFBS, a comprehensive deep learning (DL) framework that builds a robust DNA language model of TF binding grammar for accurately predicting TFBSs within and ac...

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Bibliographic Details
Main Authors: Jingjing Zhai, Yuzhou Zhang, Chujun Zhang, Xiaotong Yin, Minggui Song, Chenglong Tang, Pengjun Ding, Zenglin Li, Chuang Ma
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Advanced Science
Subjects:
bioinformatics
cross‐species prediction
deep learning
machine learning
transcriptional regulatory network
Online Access:https://doi.org/10.1002/advs.202503135
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