Association of cartilage T1ρ and T2 relaxation time measurement with hip osteoarthritis progression: A 5-year longitudinal study using voxel-based relaxometry and Z-score normalization
Objective: To study the longitudinal changes of cartilage T1ρ and T2 relaxation time measurements in hip-OA patients. Methods: A calibration study compared two scanner data, Scanner-1 (GE Discovery MR750 3.0T) with unilateral acquisition protocol and Scanner-2 (GE Signa Premier 3.0T) with bilateral...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
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| Series: | Osteoarthritis and Cartilage Open |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665913124001055 |
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| Summary: | Objective: To study the longitudinal changes of cartilage T1ρ and T2 relaxation time measurements in hip-OA patients. Methods: A calibration study compared two scanner data, Scanner-1 (GE Discovery MR750 3.0T) with unilateral acquisition protocol and Scanner-2 (GE Signa Premier 3.0T) with bilateral acquisition protocol, using nine subjects(average age = 40.33 ± 13.53 years, 5 females), including one hip-OA subject. Quantified parameters from the Scanner-2 were adjusted using voxel-based relaxometry(VBR) and Z-score normalization to reduce the inter-scanner variability. Eighteen hip-OA Subjects (age = 53.11 ± 14.96 years, 12 females) were recruited to the longitudinal variability study from 2016, comprising five assessments at 1-year intervals. Baseline to 3rd-year data used unilateral acquisition with Scanner-1, while 4th-year data used bilateral acquisition with Scanner-2. A linear mixed-effects model(LME) assessed trajectory analyses, with acquisition year, age, sex, body mass index(BMI), and Kellgren-Lawrence(KL) score as predictor variables and cartilage mean T1ρ and T2 values as outcomes. Results: VBR analysis after Z-score normalization showed that only a few of the whole cartilage voxels had significant differences in T1ρ(femur-2.36 % and acetabular-3.23 %) and T2 (femur-2.30 % and acetabular-2.94 %) values between the scanners. The LME analysis showed that the BMI predictor variable was significantly correlated with the femur T1ρ (p < 0.0001) and T2 (p < 0.0001) and acetabular T1ρ (p < 0.0001) and T2 (p < 0.0001) cartilage region. Conclusion: The calibration study demonstrated the effectiveness of VBR and Z-score normalization in reducing inter-scanner variability. The longitudinal study revealed a significant correlation between T1ρ and T2 values of the cartilage and BMI; also the T1ρ and T2 values increased over time in some of the cartilage subregions. |
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| ISSN: | 2665-9131 |