Systemic xanthogranuloma involving bone marrow and skin in a case of B-Lymphoblastic Leukemia
Juvenile xanthogranuloma is a benign self-limiting lesion commonly described in infants and young children. It most commonly involves the skin presenting as single or multiple yellowish-brown papules. Clinical scenario with the classic histomorphology showing histiocytic aggregates in the dermis wit...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_1253_21 |
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| author | Manasi C. Mundada Faiq Ahmed Suseela Kodandapani Veerendra Patil |
| author_facet | Manasi C. Mundada Faiq Ahmed Suseela Kodandapani Veerendra Patil |
| author_sort | Manasi C. Mundada |
| collection | DOAJ |
| description | Juvenile xanthogranuloma is a benign self-limiting lesion commonly described in infants and young children. It most commonly involves the skin presenting as single or multiple yellowish-brown papules. Clinical scenario with the classic histomorphology showing histiocytic aggregates in the dermis with xanthomatous cytoplasm, toutan type giant cells, immunohistochemistry with positive CD68, CD163, factor XIIIa and negative CD1a and S-100 help in diagnosis. However, diagnosis becomes challenging with predominant systemic bone marrow involvement in post-B-lymphoblastic leukemia settings. |
| format | Article |
| id | doaj-art-2a17a65bffb441df80aebc95560cd275 |
| institution | Kabale University |
| issn | 0377-4929 0974-5130 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj-art-2a17a65bffb441df80aebc95560cd2752025-01-22T15:14:12ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49290974-51302023-01-0167118518810.4103/ijpm.ijpm_1253_21Systemic xanthogranuloma involving bone marrow and skin in a case of B-Lymphoblastic LeukemiaManasi C. MundadaFaiq AhmedSuseela KodandapaniVeerendra PatilJuvenile xanthogranuloma is a benign self-limiting lesion commonly described in infants and young children. It most commonly involves the skin presenting as single or multiple yellowish-brown papules. Clinical scenario with the classic histomorphology showing histiocytic aggregates in the dermis with xanthomatous cytoplasm, toutan type giant cells, immunohistochemistry with positive CD68, CD163, factor XIIIa and negative CD1a and S-100 help in diagnosis. However, diagnosis becomes challenging with predominant systemic bone marrow involvement in post-B-lymphoblastic leukemia settings.https://journals.lww.com/10.4103/ijpm.ijpm_1253_21bone marrow involvementjuvenile xanthogranulomapost –lymphoblastic leukemia |
| spellingShingle | Manasi C. Mundada Faiq Ahmed Suseela Kodandapani Veerendra Patil Systemic xanthogranuloma involving bone marrow and skin in a case of B-Lymphoblastic Leukemia Indian Journal of Pathology and Microbiology bone marrow involvement juvenile xanthogranuloma post –lymphoblastic leukemia |
| title | Systemic xanthogranuloma involving bone marrow and skin in a case of B-Lymphoblastic Leukemia |
| title_full | Systemic xanthogranuloma involving bone marrow and skin in a case of B-Lymphoblastic Leukemia |
| title_fullStr | Systemic xanthogranuloma involving bone marrow and skin in a case of B-Lymphoblastic Leukemia |
| title_full_unstemmed | Systemic xanthogranuloma involving bone marrow and skin in a case of B-Lymphoblastic Leukemia |
| title_short | Systemic xanthogranuloma involving bone marrow and skin in a case of B-Lymphoblastic Leukemia |
| title_sort | systemic xanthogranuloma involving bone marrow and skin in a case of b lymphoblastic leukemia |
| topic | bone marrow involvement juvenile xanthogranuloma post –lymphoblastic leukemia |
| url | https://journals.lww.com/10.4103/ijpm.ijpm_1253_21 |
| work_keys_str_mv | AT manasicmundada systemicxanthogranulomainvolvingbonemarrowandskininacaseofblymphoblasticleukemia AT faiqahmed systemicxanthogranulomainvolvingbonemarrowandskininacaseofblymphoblasticleukemia AT suseelakodandapani systemicxanthogranulomainvolvingbonemarrowandskininacaseofblymphoblasticleukemia AT veerendrapatil systemicxanthogranulomainvolvingbonemarrowandskininacaseofblymphoblasticleukemia |