Intratumor heterogeneity in KRAS signaling shapes treatment resistance

Intratumor heterogeneity in KRAS signaling shapes treatment resistance

Summary: KRAS mutations are linked to some of the deadliest forms of cancer. Pharmacological studies suggest that co-targeting KRAS with feedback/bypass pathways could lead to enhanced anti-tumor activity. The underlying premise is that cancers display a deep-rooted hypersensitivity to KRAS inactiva...

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Bibliographic Details
Main Authors: Oleksi Petrenko, Varvara Kirillov, Stephen D'Amico, Nancy C. Reich
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:iScience
Subjects:
Cell biology
Cancer
Omics
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422402889X
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