Photoacoustic Imaging for Image-Guided Gastric Tube Placement: Ex Vivo Characterization
Over 250,000 gastrostomy tubes (G-tubes) are placed annually in the United States. Percutaneous endoscopic gastrostomy (PEG) is the most widely used clinical method for placing G-tubes within the stomach. However, endoscope detectability is limited due to the scattering of light by tissues. Poor org...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-03-01
|
| Series: | Sensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8220/25/5/1597 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850031259466596352 |
|---|---|
| author | Samuel John Yeidi Yuja Vaquiz Nikhila Nyayapathi Loay Kabbani Anoop Nilam Jonathan F. Lovell Nicole A. Wilson Yan Yan Mohammad Mehrmohammadi |
| author_facet | Samuel John Yeidi Yuja Vaquiz Nikhila Nyayapathi Loay Kabbani Anoop Nilam Jonathan F. Lovell Nicole A. Wilson Yan Yan Mohammad Mehrmohammadi |
| author_sort | Samuel John |
| collection | DOAJ |
| description | Over 250,000 gastrostomy tubes (G-tubes) are placed annually in the United States. Percutaneous endoscopic gastrostomy (PEG) is the most widely used clinical method for placing G-tubes within the stomach. However, endoscope detectability is limited due to the scattering of light by tissues. Poor organ visibility and low sensitivity of the palpation techniques cause blind needle insertions, which cause colon/liver perforations, abdominal bleeding, and gastric resections. Additionally, imaging artifacts and the poor distinguishability between water-filled tissues make ultrasound (US) imaging-based techniques incompatible with G-tube placement. The risk of ionizing radiation exposure and the confinement of fluoroscopy to radiology suites limits its bedside utility in patients. Considering these limitations, we propose to design a safe, point-of-care integrated US and photoacoustic (PA) imaging system for accurate G-tube placement procedures, for a broad spectrum of patients, and to characterize the system’s effectiveness. Our proposed technology utilizes a clinically safe contrast agent and a dual-wavelength approach for precise procedures. Our ex vivo tissue studies indicated that PA imaging accurately differentiates the different organs at specific wavelengths. Our characterization studies revealed that PA imaging could detect lower concentrations of Indocyanine Green (ICG) dye coating the colon wall, minimizing the risk of ICG dye-related toxicity and providing safer G-tube placements. |
| format | Article |
| id | doaj-art-2a13da53564e49f0a8c1e78d3d3d4a7c |
| institution | DOAJ |
| issn | 1424-8220 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj-art-2a13da53564e49f0a8c1e78d3d3d4a7c2025-08-20T02:59:01ZengMDPI AGSensors1424-82202025-03-01255159710.3390/s25051597Photoacoustic Imaging for Image-Guided Gastric Tube Placement: Ex Vivo CharacterizationSamuel John0Yeidi Yuja Vaquiz1Nikhila Nyayapathi2Loay Kabbani3Anoop Nilam4Jonathan F. Lovell5Nicole A. Wilson6Yan Yan7Mohammad Mehrmohammadi8Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Biomedical Engineering, Hajim School of Engineering and Applied Sciences, University of Rochester, Rochester, NY 14627, USADepartment of Imaging Sciences, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14642, USAVascular Surgery, Henry Ford Health System, Detroit, MI 48202, USADepartment of Biomedical Engineering, School of Engineering and Applied Sciences, University at Buffalo, Buffalo, NY 14260, USADepartment of Biomedical Engineering, School of Engineering and Applied Sciences, University at Buffalo, Buffalo, NY 14260, USADepartments of Surgery, Pediatrics, & Biomedical Engineering, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14642, USADepartment of Biomedical Engineering, Hajim School of Engineering and Applied Sciences, University of Rochester, Rochester, NY 14627, USADepartment of Biomedical Engineering, Hajim School of Engineering and Applied Sciences, University of Rochester, Rochester, NY 14627, USAOver 250,000 gastrostomy tubes (G-tubes) are placed annually in the United States. Percutaneous endoscopic gastrostomy (PEG) is the most widely used clinical method for placing G-tubes within the stomach. However, endoscope detectability is limited due to the scattering of light by tissues. Poor organ visibility and low sensitivity of the palpation techniques cause blind needle insertions, which cause colon/liver perforations, abdominal bleeding, and gastric resections. Additionally, imaging artifacts and the poor distinguishability between water-filled tissues make ultrasound (US) imaging-based techniques incompatible with G-tube placement. The risk of ionizing radiation exposure and the confinement of fluoroscopy to radiology suites limits its bedside utility in patients. Considering these limitations, we propose to design a safe, point-of-care integrated US and photoacoustic (PA) imaging system for accurate G-tube placement procedures, for a broad spectrum of patients, and to characterize the system’s effectiveness. Our proposed technology utilizes a clinically safe contrast agent and a dual-wavelength approach for precise procedures. Our ex vivo tissue studies indicated that PA imaging accurately differentiates the different organs at specific wavelengths. Our characterization studies revealed that PA imaging could detect lower concentrations of Indocyanine Green (ICG) dye coating the colon wall, minimizing the risk of ICG dye-related toxicity and providing safer G-tube placements.https://www.mdpi.com/1424-8220/25/5/1597gastrostomy tubeultrasoundphotoacousticimage-guidedfiberneedle |
| spellingShingle | Samuel John Yeidi Yuja Vaquiz Nikhila Nyayapathi Loay Kabbani Anoop Nilam Jonathan F. Lovell Nicole A. Wilson Yan Yan Mohammad Mehrmohammadi Photoacoustic Imaging for Image-Guided Gastric Tube Placement: Ex Vivo Characterization Sensors gastrostomy tube ultrasound photoacoustic image-guided fiber needle |
| title | Photoacoustic Imaging for Image-Guided Gastric Tube Placement: Ex Vivo Characterization |
| title_full | Photoacoustic Imaging for Image-Guided Gastric Tube Placement: Ex Vivo Characterization |
| title_fullStr | Photoacoustic Imaging for Image-Guided Gastric Tube Placement: Ex Vivo Characterization |
| title_full_unstemmed | Photoacoustic Imaging for Image-Guided Gastric Tube Placement: Ex Vivo Characterization |
| title_short | Photoacoustic Imaging for Image-Guided Gastric Tube Placement: Ex Vivo Characterization |
| title_sort | photoacoustic imaging for image guided gastric tube placement ex vivo characterization |
| topic | gastrostomy tube ultrasound photoacoustic image-guided fiber needle |
| url | https://www.mdpi.com/1424-8220/25/5/1597 |
| work_keys_str_mv | AT samueljohn photoacousticimagingforimageguidedgastrictubeplacementexvivocharacterization AT yeidiyujavaquiz photoacousticimagingforimageguidedgastrictubeplacementexvivocharacterization AT nikhilanyayapathi photoacousticimagingforimageguidedgastrictubeplacementexvivocharacterization AT loaykabbani photoacousticimagingforimageguidedgastrictubeplacementexvivocharacterization AT anoopnilam photoacousticimagingforimageguidedgastrictubeplacementexvivocharacterization AT jonathanflovell photoacousticimagingforimageguidedgastrictubeplacementexvivocharacterization AT nicoleawilson photoacousticimagingforimageguidedgastrictubeplacementexvivocharacterization AT yanyan photoacousticimagingforimageguidedgastrictubeplacementexvivocharacterization AT mohammadmehrmohammadi photoacousticimagingforimageguidedgastrictubeplacementexvivocharacterization |