Everolimus-Eluting Biodegradable Abluminal Coating Stent versus Durable Conformal Coating Stent: Termination of the Inflammatory Response Associated with Neointimal Healing in a Porcine Coronary Model
Objectives. We evaluated the effect of the different carrier systems on early vascular response through histological analysis and scanning electron microscopy using a porcine model. Background. Although Synergy™ and Promus PREMIER™ share an identical stent material and drug elution (everolimus), the...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Interventional Cardiology |
| Online Access: | http://dx.doi.org/10.1155/2020/1956015 |
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| author | Masayuki Mori Kenji Sakata Junichiro Yokawa Chiaki Nakanishi Kota Murai Hirofumi Okada Masaya Shimojima Shohei Yoshida Kazuaki Yoshioka Yoh Takuwa Kenshi Hayashi Masakazu Yamagishi Masa-aki Kawashiri |
| author_facet | Masayuki Mori Kenji Sakata Junichiro Yokawa Chiaki Nakanishi Kota Murai Hirofumi Okada Masaya Shimojima Shohei Yoshida Kazuaki Yoshioka Yoh Takuwa Kenshi Hayashi Masakazu Yamagishi Masa-aki Kawashiri |
| author_sort | Masayuki Mori |
| collection | DOAJ |
| description | Objectives. We evaluated the effect of the different carrier systems on early vascular response through histological analysis and scanning electron microscopy using a porcine model. Background. Although Synergy™ and Promus PREMIER™ share an identical stent material and drug elution (everolimus), they use different drug carrier systems: biodegradable abluminal coating polymer or durable conformal coating polymer, respectively. However, data regarding the impact of the different coating systems on vessel healing are currently limited. Methods. Twelve Synergy™ and Promus PREMIER™ were implanted in 12 swine. Histopathological analysis of the stented segments was performed on the 2nd and 14th days after implantation. Morphometric analysis of the inflammation and intimal fibrin content was also performed. Results. On the 2nd day, neointimal thickness, percentage of neointimal area, and inflammatory and intimal fibrin content scores were not significantly different between the two groups. On the 14th day, the inflammatory and intimal fibrin content scores were significantly lower in Synergy™ versus those observed in Promus PREMIER™. In Synergy™, smooth muscle cells were found and the neointimal layers were smooth. In contrast, inflammatory cells were observed surrounding the struts of Promus PREMIER™. Conclusions. These results demonstrate that termination of reactive inflammation is accelerated after abluminal coating stent versus implantation of conformal coating stent. |
| format | Article |
| id | doaj-art-2a08052352674e6f9a6632851e3de2ef |
| institution | Kabale University |
| issn | 0896-4327 1540-8183 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Interventional Cardiology |
| spelling | doaj-art-2a08052352674e6f9a6632851e3de2ef2025-02-03T01:32:22ZengWileyJournal of Interventional Cardiology0896-43271540-81832020-01-01202010.1155/2020/19560151956015Everolimus-Eluting Biodegradable Abluminal Coating Stent versus Durable Conformal Coating Stent: Termination of the Inflammatory Response Associated with Neointimal Healing in a Porcine Coronary ModelMasayuki Mori0Kenji Sakata1Junichiro Yokawa2Chiaki Nakanishi3Kota Murai4Hirofumi Okada5Masaya Shimojima6Shohei Yoshida7Kazuaki Yoshioka8Yoh Takuwa9Kenshi Hayashi10Masakazu Yamagishi11Masa-aki Kawashiri12Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, JapanDepartment of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, JapanDepartment of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, JapanDepartment of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, JapanDepartment of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, JapanDepartment of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, JapanDepartment of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, JapanDepartment of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, JapanDepartment of Molecular Vascular Physiology, Kanazawa University Graduate School of Medicine, Kanazawa, JapanDepartment of Molecular Vascular Physiology, Kanazawa University Graduate School of Medicine, Kanazawa, JapanDepartment of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, JapanOsaka University of Human Sciences, Osaka, JapanDepartment of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, JapanObjectives. We evaluated the effect of the different carrier systems on early vascular response through histological analysis and scanning electron microscopy using a porcine model. Background. Although Synergy™ and Promus PREMIER™ share an identical stent material and drug elution (everolimus), they use different drug carrier systems: biodegradable abluminal coating polymer or durable conformal coating polymer, respectively. However, data regarding the impact of the different coating systems on vessel healing are currently limited. Methods. Twelve Synergy™ and Promus PREMIER™ were implanted in 12 swine. Histopathological analysis of the stented segments was performed on the 2nd and 14th days after implantation. Morphometric analysis of the inflammation and intimal fibrin content was also performed. Results. On the 2nd day, neointimal thickness, percentage of neointimal area, and inflammatory and intimal fibrin content scores were not significantly different between the two groups. On the 14th day, the inflammatory and intimal fibrin content scores were significantly lower in Synergy™ versus those observed in Promus PREMIER™. In Synergy™, smooth muscle cells were found and the neointimal layers were smooth. In contrast, inflammatory cells were observed surrounding the struts of Promus PREMIER™. Conclusions. These results demonstrate that termination of reactive inflammation is accelerated after abluminal coating stent versus implantation of conformal coating stent.http://dx.doi.org/10.1155/2020/1956015 |
| spellingShingle | Masayuki Mori Kenji Sakata Junichiro Yokawa Chiaki Nakanishi Kota Murai Hirofumi Okada Masaya Shimojima Shohei Yoshida Kazuaki Yoshioka Yoh Takuwa Kenshi Hayashi Masakazu Yamagishi Masa-aki Kawashiri Everolimus-Eluting Biodegradable Abluminal Coating Stent versus Durable Conformal Coating Stent: Termination of the Inflammatory Response Associated with Neointimal Healing in a Porcine Coronary Model Journal of Interventional Cardiology |
| title | Everolimus-Eluting Biodegradable Abluminal Coating Stent versus Durable Conformal Coating Stent: Termination of the Inflammatory Response Associated with Neointimal Healing in a Porcine Coronary Model |
| title_full | Everolimus-Eluting Biodegradable Abluminal Coating Stent versus Durable Conformal Coating Stent: Termination of the Inflammatory Response Associated with Neointimal Healing in a Porcine Coronary Model |
| title_fullStr | Everolimus-Eluting Biodegradable Abluminal Coating Stent versus Durable Conformal Coating Stent: Termination of the Inflammatory Response Associated with Neointimal Healing in a Porcine Coronary Model |
| title_full_unstemmed | Everolimus-Eluting Biodegradable Abluminal Coating Stent versus Durable Conformal Coating Stent: Termination of the Inflammatory Response Associated with Neointimal Healing in a Porcine Coronary Model |
| title_short | Everolimus-Eluting Biodegradable Abluminal Coating Stent versus Durable Conformal Coating Stent: Termination of the Inflammatory Response Associated with Neointimal Healing in a Porcine Coronary Model |
| title_sort | everolimus eluting biodegradable abluminal coating stent versus durable conformal coating stent termination of the inflammatory response associated with neointimal healing in a porcine coronary model |
| url | http://dx.doi.org/10.1155/2020/1956015 |
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