Mechanistic insights into Sanbi Decoction for osteoarthritis treatment based on network pharmacology and experimental validation

Mechanistic insights into Sanbi Decoction for osteoarthritis treatment based on network pharmacology and experimental validation

Abstract Sanbi Decoction (SBD) has demonstrated promising therapeutic potential in osteoarthritis (OA) treatment, yet its precise mechanisms remain unclear. This research combined computational and experimental approaches, including bioinformatics analysis, network pharmacology, molecular docking, m...

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Bibliographic Details
Main Authors: Zeyu Huang, Xiaohong Jiang, Wei Xie, Kuicheng Wei, Lerong Yang, Dehuai Liu, Lianlian Zhong
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Sanbi Decoction
Osteoarthritis
Network pharmacology
Molecular docking
Molecular dynamics simulations.
Online Access:https://doi.org/10.1038/s41598-025-99055-z
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