PNPO‐Mediated Oxidation of DVL3 Promotes Multiple Myeloma Malignancy and Osteoclastogenesis by Activating the Wnt/β‐Catenin Pathway

PNPO‐Mediated Oxidation of DVL3 Promotes Multiple Myeloma Malignancy and Osteoclastogenesis by Activating the Wnt/β‐Catenin Pathway

Abstract Multiple myeloma (MM) is a cancer of plasma cells caused by abnormal gene expression and interactions within the bone marrow (BM) niche. The BM environment significantly influences the progression of MM. Celastrol, a natural compound derived from traditional Chinese medicine, exhibits signi...

Full description

Saved in:

Bibliographic Details
Main Authors:	Zhendong Deng, Shanliang Sun, Nian Zhou, Yumeng Peng, Long Cheng, Xichao Yu, Yuxia Yuan, Mengjie Guo, Min Xu, Yuexin Cheng, Fan Zhou, Nianguang Li, Ye Yang, Chunyan Gu
Format:	Article
Language:	English
Published:	Wiley 2025-02-01
Series:	Advanced Science
Subjects:	dishevelled 3 eltrombopag multiple myeloma pyridoxine‐5′‐phosphate oxidase wnt/β‐catenin pathway
Online Access:	https://doi.org/10.1002/advs.202407681
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Expression study of Wnt/β-catenin signaling pathway associated lncRNAs in schizophrenia
by: Fatemeh Manafzadeh, et al.
Published: (2025-01-01)

Detection of the WNT/Beta-Catenin Signaling Activity by Using Immunocytochemical Technique in Cervical Smears
by: Hanife Güler Dönmez, et al.
Published: (2013-08-01)

Prednisone inhibits osteosarcoma cell by regulating the Wnt/β-catenin signaling pathway
by: Yo Zhang, et al.
Published: (2024-12-01)

Oridonin ameliorates renal fibrosis in diabetic nephropathy by inhibiting the Wnt/β-catenin signaling pathway
by: Jushuang Li, et al.
Published: (2024-12-01)

UGCG promotes chemoresistance and breast cancer progression via NF-κB and Wnt/β-catenin pathway activation
by: Li Long, et al.
Published: (2025-02-01)

Anti-colon cancer activity of water-soluble polysaccharides extracted from Gloeostereum incarnatum via Wnt/β-catenin signaling pathway
by: Jiawei He, et al.
Published: (2021-07-01)

Wnt/ β-catenin and CTNNB1 gene mutation in hepatocellular carcinoma, a case study in Egyptian patients
by: Ramy A. Abdelsalam, et al.
Published: (2025-01-01)

RETRACTED ARTICLE: NR3C2 affects the proliferation and invasiveness of colon cancer cells through the Wnt/β-Catenin signaling pathway
by: Ke Nie, et al.
Published: (2024-09-01)

Knockdown of CCNB1 alleviates high glucose-triggered trophoblast dysfunction during gestational diabetes via Wnt/β-catenin signaling pathway
by: Xiao Biru, et al.
Published: (2025-01-01)

Activating Transcription Factor 5 Promotes Tumorigenic Capability in Cervical Cancer Through the Wnt/β-Catenin Signaling Pathway
by: Shi F, et al.
Published: (2025-01-01)

Diagnostic utility of LEF1 and β-catenin in WNT pathway tumors with CTNNB1 mutation
by: Can Li, et al.
Published: (2025-01-01)

Moscatilin inhibits vascular calcification by activating IL13RA2-dependent inhibition of STAT3 and attenuating the WNT3/β-catenin signalling pathway
by: Tingting Zhang, et al.
Published: (2025-02-01)

Nystose attenuates bone loss and promotes BMSCs differentiation to osteoblasts through BMP and Wnt/β-catenin pathway in ovariectomized mice
by: Qi Zhang, et al.
Published: (2023-03-01)

Gingival fibroblast suppress the osteogenesis process mediated by bone substitute materials via WNT/β-catenin signaling pathway in vitro and in vivo
by: Guanqi Liu, et al.
Published: (2025-02-01)

Activation of Wnt/β-catenin in neural progenitor cells regulates blood–brain barrier development and promotes neuroinflammation
by: Dylan J. Sebo, et al.
Published: (2025-01-01)

The mechanism of enterogenous toxin methylmalonic acid aggravating calcium-phosphorus metabolic disorder in uremic rats by regulating the Wnt/β-catenin pathway
by: Xing Fan, et al.
Published: (2025-01-01)

Cross-talk of renal cells through WNT signal transduction in the development of fibrotic kidneys
by: Yuhong Chen, et al.
Published: (2025-02-01)

Wnt signaling as a translational target in rheumatoid and psoriatic arthritis
by: Gloria Riitano, et al.
Published: (2025-02-01)

PU.1 alleviates the inhibitory effects of cigarette smoke on endothelial progenitor cell function and lung-homing through Wnt/β-catenin and CXCL12/CXCR4 pathways
by: Xue He<sup>+</sup>, et al.
Published: (2024-01-01)

Integrative transcriptomic and metabolomic reveals squalene alleviating the inflammatory response and enhancing immunity of hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ E. lanceolatu)
by: Xiaobo Yan, et al.
Published: (2025-03-01)

A rare deleterious missense mutation in the AXIN2 gene in Chinese women with polycystic ovary syndrome
by: Ying Zhang, et al.
Published: (2025-12-01)

Expression of CD68+ Tumor associated macrophages in relation to β-catenin in carcinoma stomach
by: Nikhil Sharma, et al.
Published: (2023-07-01)

Stability-indicating HPLC-PDA assay for simultaneous determination of paracetamol, thiamine and pyridoxal phosphate in tablet formulations
by: Ali Amir, et al.
Published: (2019-06-01)

Case report: Discovery of novel CTNNB1 mutations and comparison of clinical characteristics in two patients with NEDSDV
by: Eojin Lee, et al.
Published: (2025-01-01)

Balancing CIK Cell Cancer Immunotherapy and PPAR Ligands: One Potential Therapeutic Application for CNS Malignancies
by: Kira Vordermark, et al.
Published: (2024-12-01)

Effects of genetic ablation and pharmacological inhibition of HuR on gene expression, iron metabolism, and hormone levels
by: Nathalie Idlin, et al.
Published: (2025-01-01)

SHP2 promotes the epithelial-mesenchymal transition in triple negative breast cancer cells by regulating β-catenin
by: Shihan Qian, et al.
Published: (2025-01-01)

Impact of Thrombopoietin Receptor Agonists on Pathophysiology of Pediatric Immune Thrombocytopenia
by: Paschalis Evangelidis, et al.
Published: (2025-01-01)

Single‐cell landscape of the intrahepatic ecosystem in alcohol‐related liver disease
by: Xiaofang Zhao, et al.
Published: (2025-01-01)

Effect of Metadoxine on Chronic Primary Hepatopathies in Canines: Number of Cases
by: Paula María Bermúdez-Duarte, et al.
Published: (2023-09-01)

α-catenin phosphorylation is elevated during mitosis to resist apical rounding and epithelial barrier leak
by: Phuong M. Le, et al.
Published: (2025-01-01)

MYH9 promotes malignant progression of glioma cells through regulating β-catenin stability via epithelial-mesenchymal transition signaling pathway
by: Zigui Chen, et al.
Published: (2025-02-01)

Genotypic Spectrum in a Cohort of Sri Lankan Patients With Homocystinuria
by: Hewa Warawitage Dilanthi, et al.
Published: (2025-01-01)

RETRACTED: The role and molecular mechanism of Trop2 induced epithelial‐mesenchymal transition through mediated β‐catenin in gastric cancer
by: Wei Zhao, et al.
Published: (2019-03-01)

Screening of Anti-Hair Loss Plant Raw Materials Based on Reverse Network Pharmacology and Experimental Validation
by: Jiajia Xu, et al.
Published: (2025-01-01)

Assessing the diagnostic potential of SATB2 and β-catenin as biomarkers and therapeutic targets in pancreatic ductal adenocarcinoma
by: Noha Said Helal, et al.
Published: (2025-01-01)

Effect of grape seed extract on β -catenin gene expression and hyperglycemia in rats induced by streptozotocin
by: Elif Gulbahce-Mutlu, et al.

Nonylphenol promotes epithelial-mesenchymal transition in colorectal cancer cells by upregulating miR-151a-3p
by: Biao Wang, et al.
Published: (2025-01-01)

CXC chemokine receptor 7 ameliorates renal fibrosis by inhibiting β-catenin signaling and epithelial-to-mesenchymal transition in tubular epithelial cells
by: Ping Meng, et al.
Published: (2024-12-01)

The miR-1269a/PCDHGA9/CXCR4/β-catenin pathway promotes colorectal cancer invasion and metastasis
by: Haitao Mei, et al.
Published: (2024-11-01)