Insulin-Like Growth Factor (IGF)-I and Insulin in Normal and Growth-Restricted Mother/Infant Pairs
Insulin-like growth factor (IGF)-I and insulin are essential for fetal growth. We investigated perinatal changes of both factors in 40 mothers and their 20 appropriate-for-gestational-age (AGA) and 20 intrauterine-growth-restricted (IUGR) fetuses and neonates on day 1 (N1) and day 4 (N4) postpartum...
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2007/42646 |
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| author | Ariadne Malamitsi-Puchner Despina D. Briana Dimitrios Gourgiotis Maria Boutsikou Karl-Philipp Puchner Stavroula Baka Antonios Marmarinos Dimitrios Hassiakos |
| author_facet | Ariadne Malamitsi-Puchner Despina D. Briana Dimitrios Gourgiotis Maria Boutsikou Karl-Philipp Puchner Stavroula Baka Antonios Marmarinos Dimitrios Hassiakos |
| author_sort | Ariadne Malamitsi-Puchner |
| collection | DOAJ |
| description | Insulin-like growth factor (IGF)-I and insulin are essential for fetal growth. We investigated perinatal changes of both factors in 40 mothers and their 20 appropriate-for-gestational-age (AGA) and 20 intrauterine-growth-restricted (IUGR) fetuses and neonates on day 1 (N1) and day 4 (N4) postpartum. Fetal and N1, but not N4, IGF-I levels were increased
in AGA (P<.001 and P=.037, resp.). N1 insulin levels were lower in IUGR (P=.048). Maternal, fetal, and N1 IGF-I, and fetal insulin levels positively correlated with
customized centiles (r=.374, P=.035, r=.608, P<.001, r=.485, P=.006, and r=.654, P=.021, resp.). Female infants presented elevated fetal and N4 IGF-I levels (P=.023 and P=.016, resp.). Positive correlations of maternal, fetal, and neonatal IGF-I levels, and fetal
insulin levels with customized centiles underline implication of both hormones in fetal
growth. IUGR infants present gradually increasing IGF-I levels. Higher IGF-I levels are documented in
females. |
| format | Article |
| id | doaj-art-29f1116fabb44956a1bfbee182e685be |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-29f1116fabb44956a1bfbee182e685be2025-02-03T01:07:17ZengWileyMediators of Inflammation0962-93511466-18612007-01-01200710.1155/2007/4264642646Insulin-Like Growth Factor (IGF)-I and Insulin in Normal and Growth-Restricted Mother/Infant PairsAriadne Malamitsi-Puchner0Despina D. Briana1Dimitrios Gourgiotis2Maria Boutsikou3Karl-Philipp Puchner4Stavroula Baka5Antonios Marmarinos6Dimitrios Hassiakos7Neonatal Division, Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens 10682, GreeceNeonatal Division, Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens 10682, GreeceResearch Laboratories, Second Department of Pediatrics, Athens University Medical School, Athens 11527, GreeceNeonatal Division, Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens 10682, GreeceNeonatal Division, Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens 10682, GreeceNeonatal Division, Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens 10682, GreeceResearch Laboratories, Second Department of Pediatrics, Athens University Medical School, Athens 11527, GreeceNeonatal Division, Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens 10682, GreeceInsulin-like growth factor (IGF)-I and insulin are essential for fetal growth. We investigated perinatal changes of both factors in 40 mothers and their 20 appropriate-for-gestational-age (AGA) and 20 intrauterine-growth-restricted (IUGR) fetuses and neonates on day 1 (N1) and day 4 (N4) postpartum. Fetal and N1, but not N4, IGF-I levels were increased in AGA (P<.001 and P=.037, resp.). N1 insulin levels were lower in IUGR (P=.048). Maternal, fetal, and N1 IGF-I, and fetal insulin levels positively correlated with customized centiles (r=.374, P=.035, r=.608, P<.001, r=.485, P=.006, and r=.654, P=.021, resp.). Female infants presented elevated fetal and N4 IGF-I levels (P=.023 and P=.016, resp.). Positive correlations of maternal, fetal, and neonatal IGF-I levels, and fetal insulin levels with customized centiles underline implication of both hormones in fetal growth. IUGR infants present gradually increasing IGF-I levels. Higher IGF-I levels are documented in females.http://dx.doi.org/10.1155/2007/42646 |
| spellingShingle | Ariadne Malamitsi-Puchner Despina D. Briana Dimitrios Gourgiotis Maria Boutsikou Karl-Philipp Puchner Stavroula Baka Antonios Marmarinos Dimitrios Hassiakos Insulin-Like Growth Factor (IGF)-I and Insulin in Normal and Growth-Restricted Mother/Infant Pairs Mediators of Inflammation |
| title | Insulin-Like Growth Factor (IGF)-I and Insulin in Normal and
Growth-Restricted Mother/Infant Pairs |
| title_full | Insulin-Like Growth Factor (IGF)-I and Insulin in Normal and
Growth-Restricted Mother/Infant Pairs |
| title_fullStr | Insulin-Like Growth Factor (IGF)-I and Insulin in Normal and
Growth-Restricted Mother/Infant Pairs |
| title_full_unstemmed | Insulin-Like Growth Factor (IGF)-I and Insulin in Normal and
Growth-Restricted Mother/Infant Pairs |
| title_short | Insulin-Like Growth Factor (IGF)-I and Insulin in Normal and
Growth-Restricted Mother/Infant Pairs |
| title_sort | insulin like growth factor igf i and insulin in normal and growth restricted mother infant pairs |
| url | http://dx.doi.org/10.1155/2007/42646 |
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