Retinal microvasculature alteration in patients with acute pancreatitis: an observational OCTA study
Abstract Objective To evaluate changes in retinal layer thickness and microvascular density in pancreatitis patients using optical coherence tomography angiography (OCTA). Methods The study involved 16 pancreatitis patients and 16 healthy controls. Each participant underwent a superficial OCTA scan,...
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BMC
2025-05-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-025-02566-8 |
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| author | Xian-Zhe Qian Jin-Yu Hu Yan-Mei Zeng Hong Wei Xiao-Yu Wang Cheng Chen Qian-Min Ge Jie Zou Xian-Mei Zhou Qian Ling Liang-Qi He Xuan Liao Yi Shao |
| author_facet | Xian-Zhe Qian Jin-Yu Hu Yan-Mei Zeng Hong Wei Xiao-Yu Wang Cheng Chen Qian-Min Ge Jie Zou Xian-Mei Zhou Qian Ling Liang-Qi He Xuan Liao Yi Shao |
| author_sort | Xian-Zhe Qian |
| collection | DOAJ |
| description | Abstract Objective To evaluate changes in retinal layer thickness and microvascular density in pancreatitis patients using optical coherence tomography angiography (OCTA). Methods The study involved 16 pancreatitis patients and 16 healthy controls. Each participant underwent a superficial OCTA scan, with images divided into nine subregions to compare macular retinal thickness (RT) and superficial vascular density (SVD) between groups. Results Pancreatitis patients exhibited reduced retinal thickness in specific macular areas, including inner, full, and outer layers (p < 0.05). Additionally, decreased superficial vascular density was noted in inner superior (IS), outer superior (OS), inner nasal (IN), and outer nasal (ON) regions (p < 0.05). ROC curve analysis showed high diagnostic accuracy for full-layer inner superior, outer superior, and outer inferior thickness with areas under the curve of 0.9429, 0.9233, and 0.9990, respectively. Conclusions Pancreatitis is associated with macular retinal thinning and decreased superficial vascular density, offering potential for improved diagnostic imaging. |
| format | Article |
| id | doaj-art-29e0439d9d744af0a3743ab938e5f7e9 |
| institution | OA Journals |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-29e0439d9d744af0a3743ab938e5f7e92025-08-20T02:39:04ZengBMCEuropean Journal of Medical Research2047-783X2025-05-0130111110.1186/s40001-025-02566-8Retinal microvasculature alteration in patients with acute pancreatitis: an observational OCTA studyXian-Zhe Qian0Jin-Yu Hu1Yan-Mei Zeng2Hong Wei3Xiao-Yu Wang4Cheng Chen5Qian-Min Ge6Jie Zou7Xian-Mei Zhou8Qian Ling9Liang-Qi He10Xuan Liao11Yi Shao12Department of Ophthalmology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Ophthalmology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Ophthalmology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Ophthalmology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Ophthalmology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Ophthalmology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Ophthalmology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Ophthalmology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityOphthalmology Department of Affiliated Hospital, Medical School of Ophthalmology and Optometry, North Sichuan Medical CollegeDepartment of Ophthalmology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Ophthalmology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityOphthalmology Department of Affiliated Hospital, Medical School of Ophthalmology and Optometry, North Sichuan Medical CollegeDepartment of Ophthalmology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityAbstract Objective To evaluate changes in retinal layer thickness and microvascular density in pancreatitis patients using optical coherence tomography angiography (OCTA). Methods The study involved 16 pancreatitis patients and 16 healthy controls. Each participant underwent a superficial OCTA scan, with images divided into nine subregions to compare macular retinal thickness (RT) and superficial vascular density (SVD) between groups. Results Pancreatitis patients exhibited reduced retinal thickness in specific macular areas, including inner, full, and outer layers (p < 0.05). Additionally, decreased superficial vascular density was noted in inner superior (IS), outer superior (OS), inner nasal (IN), and outer nasal (ON) regions (p < 0.05). ROC curve analysis showed high diagnostic accuracy for full-layer inner superior, outer superior, and outer inferior thickness with areas under the curve of 0.9429, 0.9233, and 0.9990, respectively. Conclusions Pancreatitis is associated with macular retinal thinning and decreased superficial vascular density, offering potential for improved diagnostic imaging.https://doi.org/10.1186/s40001-025-02566-8PancreatitisRetinal thicknessOptical coherence tomography angiography (OCTA)Superficial vascular densityMacular region |
| spellingShingle | Xian-Zhe Qian Jin-Yu Hu Yan-Mei Zeng Hong Wei Xiao-Yu Wang Cheng Chen Qian-Min Ge Jie Zou Xian-Mei Zhou Qian Ling Liang-Qi He Xuan Liao Yi Shao Retinal microvasculature alteration in patients with acute pancreatitis: an observational OCTA study European Journal of Medical Research Pancreatitis Retinal thickness Optical coherence tomography angiography (OCTA) Superficial vascular density Macular region |
| title | Retinal microvasculature alteration in patients with acute pancreatitis: an observational OCTA study |
| title_full | Retinal microvasculature alteration in patients with acute pancreatitis: an observational OCTA study |
| title_fullStr | Retinal microvasculature alteration in patients with acute pancreatitis: an observational OCTA study |
| title_full_unstemmed | Retinal microvasculature alteration in patients with acute pancreatitis: an observational OCTA study |
| title_short | Retinal microvasculature alteration in patients with acute pancreatitis: an observational OCTA study |
| title_sort | retinal microvasculature alteration in patients with acute pancreatitis an observational octa study |
| topic | Pancreatitis Retinal thickness Optical coherence tomography angiography (OCTA) Superficial vascular density Macular region |
| url | https://doi.org/10.1186/s40001-025-02566-8 |
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