Autologous Minimally Invasive Cell-Based Therapy for Meniscal and Anterior Cruciate Ligament Regeneration
The meniscus is a fibrocartilaginous tissue that acts as a “shock absorber,” along with performing functions such as stabilization and lubrication of the joint, proprioception, and load distribution. Sudden twisting movements during weight bearing or trauma can cause injury to the menisci, which lea...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Orthopedics |
| Online Access: | http://dx.doi.org/10.1155/2021/6614232 |
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| author | Pradeep V. Mahajan Swetha Subramanian Siddhesh C. Parab Sanskruti Mahajan |
| author_facet | Pradeep V. Mahajan Swetha Subramanian Siddhesh C. Parab Sanskruti Mahajan |
| author_sort | Pradeep V. Mahajan |
| collection | DOAJ |
| description | The meniscus is a fibrocartilaginous tissue that acts as a “shock absorber,” along with performing functions such as stabilization and lubrication of the joint, proprioception, and load distribution. Sudden twisting movements during weight bearing or trauma can cause injury to the menisci, which leads to symptoms such as pain, swelling, and difficulty in performing movements, among others. Conventional pharmacological and surgical treatments are effective in treating the condition; however, do not result in regeneration of healthy tissues. In this report, we highlight the role of cell-based therapy in the management of medial and lateral meniscal and anterior cruciate ligament tears in a patient who was unwilling to undergo surgical treatment. We injected autologous mesenchymal stem cells obtained from the bone marrow and adipose tissue and platelet-rich plasma into the joint of the patient at the area of injury, as well as intravenously. The results of our study corroborate with those previously reported in the literature regarding the improvement in clinical parameters and regeneration of meniscal tissue and ligament. Thus, based on previous literature and improvements noticed in our patient, cell-based therapy can be considered a safe and effective therapeutic modality in the treatment of meniscal tears and cruciate ligament injury. |
| format | Article |
| id | doaj-art-29dbe078484442ca8975200fdb83813a |
| institution | Kabale University |
| issn | 2090-6749 2090-6757 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Orthopedics |
| spelling | doaj-art-29dbe078484442ca8975200fdb83813a2025-02-03T01:27:02ZengWileyCase Reports in Orthopedics2090-67492090-67572021-01-01202110.1155/2021/66142326614232Autologous Minimally Invasive Cell-Based Therapy for Meniscal and Anterior Cruciate Ligament RegenerationPradeep V. Mahajan0Swetha Subramanian1Siddhesh C. Parab2Sanskruti Mahajan3StemRx Bioscience Solutions Pvt. Ltd., Navi Mumbai, IndiaStemRx Bioscience Solutions Pvt. Ltd., Navi Mumbai, IndiaStemRx Bioscience Solutions Pvt. Ltd., Navi Mumbai, IndiaDepartment of Surgery, Indianapolis University School of Medicine, USAThe meniscus is a fibrocartilaginous tissue that acts as a “shock absorber,” along with performing functions such as stabilization and lubrication of the joint, proprioception, and load distribution. Sudden twisting movements during weight bearing or trauma can cause injury to the menisci, which leads to symptoms such as pain, swelling, and difficulty in performing movements, among others. Conventional pharmacological and surgical treatments are effective in treating the condition; however, do not result in regeneration of healthy tissues. In this report, we highlight the role of cell-based therapy in the management of medial and lateral meniscal and anterior cruciate ligament tears in a patient who was unwilling to undergo surgical treatment. We injected autologous mesenchymal stem cells obtained from the bone marrow and adipose tissue and platelet-rich plasma into the joint of the patient at the area of injury, as well as intravenously. The results of our study corroborate with those previously reported in the literature regarding the improvement in clinical parameters and regeneration of meniscal tissue and ligament. Thus, based on previous literature and improvements noticed in our patient, cell-based therapy can be considered a safe and effective therapeutic modality in the treatment of meniscal tears and cruciate ligament injury.http://dx.doi.org/10.1155/2021/6614232 |
| spellingShingle | Pradeep V. Mahajan Swetha Subramanian Siddhesh C. Parab Sanskruti Mahajan Autologous Minimally Invasive Cell-Based Therapy for Meniscal and Anterior Cruciate Ligament Regeneration Case Reports in Orthopedics |
| title | Autologous Minimally Invasive Cell-Based Therapy for Meniscal and Anterior Cruciate Ligament Regeneration |
| title_full | Autologous Minimally Invasive Cell-Based Therapy for Meniscal and Anterior Cruciate Ligament Regeneration |
| title_fullStr | Autologous Minimally Invasive Cell-Based Therapy for Meniscal and Anterior Cruciate Ligament Regeneration |
| title_full_unstemmed | Autologous Minimally Invasive Cell-Based Therapy for Meniscal and Anterior Cruciate Ligament Regeneration |
| title_short | Autologous Minimally Invasive Cell-Based Therapy for Meniscal and Anterior Cruciate Ligament Regeneration |
| title_sort | autologous minimally invasive cell based therapy for meniscal and anterior cruciate ligament regeneration |
| url | http://dx.doi.org/10.1155/2021/6614232 |
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