Alternative Splicing and Its Impact as a Cancer Diagnostic Marker
Most genes are processed by alternative splicing for gene expression, resulting in the complexity of the transcriptome in eukaryotes. It allows a limited number of genes to encode various proteins with intricate functions. Alternative splicing is regulated by genetic mutations in cis-regulatory fact...
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BioMed Central
2012-06-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gni-10-74.pdf |
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| author | Yun-Ji Kim Heui-Soo Kim |
| author_facet | Yun-Ji Kim Heui-Soo Kim |
| author_sort | Yun-Ji Kim |
| collection | DOAJ |
| description | Most genes are processed by alternative splicing for gene expression, resulting in the complexity of the transcriptome in eukaryotes. It allows a limited number of genes to encode various proteins with intricate functions. Alternative splicing is regulated by genetic mutations in cis-regulatory factors and epigenetic events. Furthermore, splicing events occur differently according to cell type, developmental stage, and various diseases, including cancer. Genome instability and flexible proteomes by alternative splicing could affect cancer cells to grow and survive, leading to metastasis. Cancer cells that are transformed by aberrant and uncontrolled mechanisms could produce alternative splicing to maintain and spread them continuously. Splicing variants in various cancers represent crucial roles for tumorigenesis. Taken together, the identification of alternative spliced variants as biomarkers to distinguish between normal and cancer cells could cast light on tumorigenesis. |
| format | Article |
| id | doaj-art-29d223c2c1084ce99a6d7f03d22cb85f |
| institution | Kabale University |
| issn | 1598-866X 2234-0742 |
| language | English |
| publishDate | 2012-06-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-29d223c2c1084ce99a6d7f03d22cb85f2025-02-02T02:22:19ZengBioMed CentralGenomics & Informatics1598-866X2234-07422012-06-01102748010.5808/GI.2012.10.2.7443Alternative Splicing and Its Impact as a Cancer Diagnostic MarkerYun-Ji Kim0Heui-Soo Kim1Department of Biological Sciences, College of Natural Sciences, Pusan National University, Busan 609-735, Korea.Department of Biological Sciences, College of Natural Sciences, Pusan National University, Busan 609-735, Korea.Most genes are processed by alternative splicing for gene expression, resulting in the complexity of the transcriptome in eukaryotes. It allows a limited number of genes to encode various proteins with intricate functions. Alternative splicing is regulated by genetic mutations in cis-regulatory factors and epigenetic events. Furthermore, splicing events occur differently according to cell type, developmental stage, and various diseases, including cancer. Genome instability and flexible proteomes by alternative splicing could affect cancer cells to grow and survive, leading to metastasis. Cancer cells that are transformed by aberrant and uncontrolled mechanisms could produce alternative splicing to maintain and spread them continuously. Splicing variants in various cancers represent crucial roles for tumorigenesis. Taken together, the identification of alternative spliced variants as biomarkers to distinguish between normal and cancer cells could cast light on tumorigenesis.http://genominfo.org/upload/pdf/gni-10-74.pdfalternative splicingbiological markersneoplasmsneoplastic cell transformation |
| spellingShingle | Yun-Ji Kim Heui-Soo Kim Alternative Splicing and Its Impact as a Cancer Diagnostic Marker Genomics & Informatics alternative splicing biological markers neoplasms neoplastic cell transformation |
| title | Alternative Splicing and Its Impact as a Cancer Diagnostic Marker |
| title_full | Alternative Splicing and Its Impact as a Cancer Diagnostic Marker |
| title_fullStr | Alternative Splicing and Its Impact as a Cancer Diagnostic Marker |
| title_full_unstemmed | Alternative Splicing and Its Impact as a Cancer Diagnostic Marker |
| title_short | Alternative Splicing and Its Impact as a Cancer Diagnostic Marker |
| title_sort | alternative splicing and its impact as a cancer diagnostic marker |
| topic | alternative splicing biological markers neoplasms neoplastic cell transformation |
| url | http://genominfo.org/upload/pdf/gni-10-74.pdf |
| work_keys_str_mv | AT yunjikim alternativesplicinganditsimpactasacancerdiagnosticmarker AT heuisookim alternativesplicinganditsimpactasacancerdiagnosticmarker |