Clinical Efficacy of Probiotic Therapy on Bowel-Related Symptoms in Patients with Ulcerative Colitis during Endoscopic Remission: An Observational Study
Background. A substantial percentage of patients with ulcerative colitis (UC) have irritable bowel syndrome- (IBS-) like symptoms despite adequate treatment and endoscopic remission. In this study, we evaluated the clinical efficacy of probiotic therapy for residual IBS-like symptoms in patients wit...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2022/9872230 |
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| author | Jin Lee Su Bum Park Hyung Wook Kim Hong Sub Lee Sam Ryong Jee Jong Hun Lee Tae Oh Kim |
| author_facet | Jin Lee Su Bum Park Hyung Wook Kim Hong Sub Lee Sam Ryong Jee Jong Hun Lee Tae Oh Kim |
| author_sort | Jin Lee |
| collection | DOAJ |
| description | Background. A substantial percentage of patients with ulcerative colitis (UC) have irritable bowel syndrome- (IBS-) like symptoms despite adequate treatment and endoscopic remission. In this study, we evaluated the clinical efficacy of probiotic therapy for residual IBS-like symptoms in patients with UC in endoscopic remission. Methods. We conducted a multicenter, observational study between April 2018 and December 2020 across two university hospitals in Korea. Patients with UC whose IBS-like symptoms persisted during endoscopic remission were included in this study. Endoscopic remission was defined as a Mayo endoscopic score≤1, and IBS-like symptoms were defined as those meeting the ROME-IV diagnostic criteria. A Biotop capsule® (Lactobacillus acidophilus, 75 mg; Clostridium butyricum TO-A, 25 mg; Bacillus mesentericus TO-A, 25 mg; and Streptococcus faecalis T-110, 5 mg) was administered three times daily for one month. All patients completed bowel-related symptom questionnaires and short inflammatory bowel disease questionnaires (SIBDQs) at the start and end of the 4-week treatment period. Results. A total of 43 patients were enrolled and analyzed. Statistically significant improvements from baseline were observed at the end of the 4-week treatment. The total SIBDQ score improved from 50.6 to 53.6 (P=0.005). SIBDQ scores of bowel function (P=0.018), systemic function (P=0.040), and social function (P=0.005) improved. Stool frequency and Bristol stool scale scores improved after probiotic therapy (P<0.05). Conclusion. This study showed that probiotic administration improved bowel-related symptoms and quality of life in patients with UC whose IBS-like symptoms persisted during endoscopic remission. As this is an observational study and has no placebo-controlled arm, further prospective randomized controlled trials are needed to confirm these results. |
| format | Article |
| id | doaj-art-29b5118071df4f9490c1342691f7755d |
| institution | Kabale University |
| issn | 1687-630X |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-29b5118071df4f9490c1342691f7755d2025-02-03T01:08:58ZengWileyGastroenterology Research and Practice1687-630X2022-01-01202210.1155/2022/9872230Clinical Efficacy of Probiotic Therapy on Bowel-Related Symptoms in Patients with Ulcerative Colitis during Endoscopic Remission: An Observational StudyJin Lee0Su Bum Park1Hyung Wook Kim2Hong Sub Lee3Sam Ryong Jee4Jong Hun Lee5Tae Oh Kim6Division of GastroenterologyDivision of GastroenterologyDivision of GastroenterologyDivision of GastroenterologyDivision of GastroenterologyDivision of GastroenterologyDivision of GastroenterologyBackground. A substantial percentage of patients with ulcerative colitis (UC) have irritable bowel syndrome- (IBS-) like symptoms despite adequate treatment and endoscopic remission. In this study, we evaluated the clinical efficacy of probiotic therapy for residual IBS-like symptoms in patients with UC in endoscopic remission. Methods. We conducted a multicenter, observational study between April 2018 and December 2020 across two university hospitals in Korea. Patients with UC whose IBS-like symptoms persisted during endoscopic remission were included in this study. Endoscopic remission was defined as a Mayo endoscopic score≤1, and IBS-like symptoms were defined as those meeting the ROME-IV diagnostic criteria. A Biotop capsule® (Lactobacillus acidophilus, 75 mg; Clostridium butyricum TO-A, 25 mg; Bacillus mesentericus TO-A, 25 mg; and Streptococcus faecalis T-110, 5 mg) was administered three times daily for one month. All patients completed bowel-related symptom questionnaires and short inflammatory bowel disease questionnaires (SIBDQs) at the start and end of the 4-week treatment period. Results. A total of 43 patients were enrolled and analyzed. Statistically significant improvements from baseline were observed at the end of the 4-week treatment. The total SIBDQ score improved from 50.6 to 53.6 (P=0.005). SIBDQ scores of bowel function (P=0.018), systemic function (P=0.040), and social function (P=0.005) improved. Stool frequency and Bristol stool scale scores improved after probiotic therapy (P<0.05). Conclusion. This study showed that probiotic administration improved bowel-related symptoms and quality of life in patients with UC whose IBS-like symptoms persisted during endoscopic remission. As this is an observational study and has no placebo-controlled arm, further prospective randomized controlled trials are needed to confirm these results.http://dx.doi.org/10.1155/2022/9872230 |
| spellingShingle | Jin Lee Su Bum Park Hyung Wook Kim Hong Sub Lee Sam Ryong Jee Jong Hun Lee Tae Oh Kim Clinical Efficacy of Probiotic Therapy on Bowel-Related Symptoms in Patients with Ulcerative Colitis during Endoscopic Remission: An Observational Study Gastroenterology Research and Practice |
| title | Clinical Efficacy of Probiotic Therapy on Bowel-Related Symptoms in Patients with Ulcerative Colitis during Endoscopic Remission: An Observational Study |
| title_full | Clinical Efficacy of Probiotic Therapy on Bowel-Related Symptoms in Patients with Ulcerative Colitis during Endoscopic Remission: An Observational Study |
| title_fullStr | Clinical Efficacy of Probiotic Therapy on Bowel-Related Symptoms in Patients with Ulcerative Colitis during Endoscopic Remission: An Observational Study |
| title_full_unstemmed | Clinical Efficacy of Probiotic Therapy on Bowel-Related Symptoms in Patients with Ulcerative Colitis during Endoscopic Remission: An Observational Study |
| title_short | Clinical Efficacy of Probiotic Therapy on Bowel-Related Symptoms in Patients with Ulcerative Colitis during Endoscopic Remission: An Observational Study |
| title_sort | clinical efficacy of probiotic therapy on bowel related symptoms in patients with ulcerative colitis during endoscopic remission an observational study |
| url | http://dx.doi.org/10.1155/2022/9872230 |
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