Auricularia polytricha noodles prevent hyperlipemia and modulate gut microbiota in high-fat diet fed mice
Auricularia polytricha possesses hypolipidemic effects and decreases lipid accumulation, leading to potential food additives for functional food processing. In this research, we explored the potential effects of A. polytricha noodles on hyperlipidemia and gut microbiota dysbiosis, and elucidated the...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2021-07-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453021000525 |
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| author | Donglu Fang Dan Wang Gaoxing Ma Yang Ji Huihua Zheng Hui Chen Mingwen Zhao Qiuhui Hu Liyan Zhao |
| author_facet | Donglu Fang Dan Wang Gaoxing Ma Yang Ji Huihua Zheng Hui Chen Mingwen Zhao Qiuhui Hu Liyan Zhao |
| author_sort | Donglu Fang |
| collection | DOAJ |
| description | Auricularia polytricha possesses hypolipidemic effects and decreases lipid accumulation, leading to potential food additives for functional food processing. In this research, we explored the potential effects of A. polytricha noodles on hyperlipidemia and gut microbiota dysbiosis, and elucidated their possible regulatory mechanisms on lipid metabolism in high-fat diet (HFD) mice. A. polytricha noodles treatment significantly (P < 0.05) reduced body weight gain, hyperlipidemia and liver fat accumulation. Meanwhile, A. polytricha noodles decreased the levels of serum total cholesterol (TC), total triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) compared with the HFD group. Furthermore, A. polytricha noodles could enrich the diversity of gut microbiota by decreasing the ratio of Firmicutes to Bacteroidetes as well as the relative abundance of Deferribacteres and increased the relative abundance of Verrucomicrobia, which might contribute to the prevention of hyperlipidemia. This study indicated that A. polytricha noodles could modulate the gut microbiota and prevent hyperlipidemia and liver fat accumulation induced by HFD. |
| format | Article |
| id | doaj-art-29b19e2b43a44456b59f5e0d8f5d70a2 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2021-07-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-29b19e2b43a44456b59f5e0d8f5d70a22025-02-03T04:08:20ZengTsinghua University PressFood Science and Human Wellness2213-45302021-07-01104431441Auricularia polytricha noodles prevent hyperlipemia and modulate gut microbiota in high-fat diet fed miceDonglu Fang0Dan Wang1Gaoxing Ma2Yang Ji3Huihua Zheng4Hui Chen5Mingwen Zhao6Qiuhui Hu7Liyan Zhao8College of Food Science and Technology, Nanjing Agricultural University/Key Laboratory of Edible Mushroom Processing, Ministry of Agriculture and Rural Affairs, Nanjing 210095, ChinaCollege of Food Science and Engineering, Nanjing University of Finance and Economics, Nanjing 210023, ChinaCollege of Food Science and Engineering, Nanjing University of Finance and Economics, Nanjing 210023, ChinaCollege of Food Science and Technology, Nanjing Agricultural University/Key Laboratory of Edible Mushroom Processing, Ministry of Agriculture and Rural Affairs, Nanjing 210095, ChinaCollege of Food Science and Technology, Nanjing Agricultural University/Key Laboratory of Edible Mushroom Processing, Ministry of Agriculture and Rural Affairs, Nanjing 210095, China; Jiangsu Alphay Bio-technology Co., Ltd., Nantong 226009, ChinaCollege of Food Science and Technology, Nanjing Agricultural University/Key Laboratory of Edible Mushroom Processing, Ministry of Agriculture and Rural Affairs, Nanjing 210095, China; Jiangsu Alphay Bio-technology Co., Ltd., Nantong 226009, ChinaCollege of Life Sciences, Nanjing Agricultural University, Nanjing, Jiangsu 210095, ChinaCollege of Food Science and Technology, Nanjing Agricultural University/Key Laboratory of Edible Mushroom Processing, Ministry of Agriculture and Rural Affairs, Nanjing 210095, ChinaCollege of Food Science and Technology, Nanjing Agricultural University/Key Laboratory of Edible Mushroom Processing, Ministry of Agriculture and Rural Affairs, Nanjing 210095, China; Corresponding author.Auricularia polytricha possesses hypolipidemic effects and decreases lipid accumulation, leading to potential food additives for functional food processing. In this research, we explored the potential effects of A. polytricha noodles on hyperlipidemia and gut microbiota dysbiosis, and elucidated their possible regulatory mechanisms on lipid metabolism in high-fat diet (HFD) mice. A. polytricha noodles treatment significantly (P < 0.05) reduced body weight gain, hyperlipidemia and liver fat accumulation. Meanwhile, A. polytricha noodles decreased the levels of serum total cholesterol (TC), total triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) compared with the HFD group. Furthermore, A. polytricha noodles could enrich the diversity of gut microbiota by decreasing the ratio of Firmicutes to Bacteroidetes as well as the relative abundance of Deferribacteres and increased the relative abundance of Verrucomicrobia, which might contribute to the prevention of hyperlipidemia. This study indicated that A. polytricha noodles could modulate the gut microbiota and prevent hyperlipidemia and liver fat accumulation induced by HFD.http://www.sciencedirect.com/science/article/pii/S2213453021000525Auricularia polytricha noodlesHyperlipidemiaLipid metabolismGut microbiota |
| spellingShingle | Donglu Fang Dan Wang Gaoxing Ma Yang Ji Huihua Zheng Hui Chen Mingwen Zhao Qiuhui Hu Liyan Zhao Auricularia polytricha noodles prevent hyperlipemia and modulate gut microbiota in high-fat diet fed mice Food Science and Human Wellness Auricularia polytricha noodles Hyperlipidemia Lipid metabolism Gut microbiota |
| title | Auricularia polytricha noodles prevent hyperlipemia and modulate gut microbiota in high-fat diet fed mice |
| title_full | Auricularia polytricha noodles prevent hyperlipemia and modulate gut microbiota in high-fat diet fed mice |
| title_fullStr | Auricularia polytricha noodles prevent hyperlipemia and modulate gut microbiota in high-fat diet fed mice |
| title_full_unstemmed | Auricularia polytricha noodles prevent hyperlipemia and modulate gut microbiota in high-fat diet fed mice |
| title_short | Auricularia polytricha noodles prevent hyperlipemia and modulate gut microbiota in high-fat diet fed mice |
| title_sort | auricularia polytricha noodles prevent hyperlipemia and modulate gut microbiota in high fat diet fed mice |
| topic | Auricularia polytricha noodles Hyperlipidemia Lipid metabolism Gut microbiota |
| url | http://www.sciencedirect.com/science/article/pii/S2213453021000525 |
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