Pectin‐decorated selenium nanoparticles as a nanocarrier of curcumin to achieve enhanced physicochemical and biological properties
In this study, the authors developed pectin‐stabilised selenium nanoparticles (pectin‐SeNPs) for curcumin (Cur) encapsulation and evaluated their physicochemical properties and biological activities. Results showed that pectin‐SeNPs and Cur‐loaded pectin‐SeNPs (pectin‐SeNPs@Cur) exhibited monodisper...
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| Format: | Article |
| Language: | English |
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Wiley
2019-10-01
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| Series: | IET Nanobiotechnology |
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| Online Access: | https://doi.org/10.1049/iet-nbt.2019.0144 |
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| author | Yan Wu Hong Liu Zhihua Li Dongye Huang Lizheng Nong Zhengxing Ning Zhizhong Hu Chunping Xu Jing‐Kun Yan |
| author_facet | Yan Wu Hong Liu Zhihua Li Dongye Huang Lizheng Nong Zhengxing Ning Zhizhong Hu Chunping Xu Jing‐Kun Yan |
| author_sort | Yan Wu |
| collection | DOAJ |
| description | In this study, the authors developed pectin‐stabilised selenium nanoparticles (pectin‐SeNPs) for curcumin (Cur) encapsulation and evaluated their physicochemical properties and biological activities. Results showed that pectin‐SeNPs and Cur‐loaded pectin‐SeNPs (pectin‐SeNPs@Cur) exhibited monodisperse and homogeneous spherical structures in aqueous solutions with mean particle sizes of ∼61 and ∼119 nm, respectively. Cur was successfully encapsulated into pectin‐SeNPs through hydrogen bonding interactions with an encapsulation efficiency of ∼60.6%, a loading content of ∼7.4%, and a pH‐dependent and controlled drug release in vitro. After encapsulation was completed, pectin‐SeNPs@Cur showed enhanced water solubility (∼500‐fold), dispersibility, and storage stability compared with those of free Cur. Moreover, pectin‐SeNPs@Cur possessed significant free radical scavenging ability and antioxidant capacity in vitro, which were stronger than those of pectin‐SeNPs. Antitumour activity assay in vitro demonstrated that pectin‐SeNPs@Cur could inhibit the growth of HepG2 cells in a concentration‐dependent manner, and the nanocarrier pectin‐SeNPs exhibited a low cytotoxic activity against HepG2 cells. Therefore, the results suggested that pectin‐SeNPs could function as effective nanovectors for the enhancement of the water solubility, stability, and in vitro bioactivities of hydrophobic Cur. |
| format | Article |
| id | doaj-art-29a5cad2f9ab4d5e8d763edbe3de5079 |
| institution | Kabale University |
| issn | 1751-8741 1751-875X |
| language | English |
| publishDate | 2019-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | IET Nanobiotechnology |
| spelling | doaj-art-29a5cad2f9ab4d5e8d763edbe3de50792025-02-03T01:29:41ZengWileyIET Nanobiotechnology1751-87411751-875X2019-10-0113888088610.1049/iet-nbt.2019.0144Pectin‐decorated selenium nanoparticles as a nanocarrier of curcumin to achieve enhanced physicochemical and biological propertiesYan Wu0Hong Liu1Zhihua Li2Dongye Huang3Lizheng Nong4Zhengxing Ning5Zhizhong Hu6Chunping Xu7Jing‐Kun Yan8Technical Center of China Tobacco Guangxi Industrial Co. Ltd.NanningGuangxi 530001People's Republic of ChinaTechnical Center of China Tobacco Guangxi Industrial Co. Ltd.NanningGuangxi 530001People's Republic of ChinaTechnical Center of China Tobacco Guangxi Industrial Co. Ltd.NanningGuangxi 530001People's Republic of ChinaTechnical Center of China Tobacco Guangxi Industrial Co. Ltd.NanningGuangxi 530001People's Republic of ChinaTechnical Center of China Tobacco Guangxi Industrial Co. Ltd.NanningGuangxi 530001People's Republic of ChinaTechnical Center of China Tobacco Guangxi Industrial Co. Ltd.NanningGuangxi 530001People's Republic of ChinaTechnical Center of China Tobacco Guangxi Industrial Co. Ltd.NanningGuangxi 530001People's Republic of ChinaCollege of Food and Biology Engineering, Zhengzhou University of Light IndustryZhengzhou 450016People's Republic of ChinaSchool of Food & Biological Engineering, Jiangsu UniversityZhenjiang 212013People's Republic of ChinaIn this study, the authors developed pectin‐stabilised selenium nanoparticles (pectin‐SeNPs) for curcumin (Cur) encapsulation and evaluated their physicochemical properties and biological activities. Results showed that pectin‐SeNPs and Cur‐loaded pectin‐SeNPs (pectin‐SeNPs@Cur) exhibited monodisperse and homogeneous spherical structures in aqueous solutions with mean particle sizes of ∼61 and ∼119 nm, respectively. Cur was successfully encapsulated into pectin‐SeNPs through hydrogen bonding interactions with an encapsulation efficiency of ∼60.6%, a loading content of ∼7.4%, and a pH‐dependent and controlled drug release in vitro. After encapsulation was completed, pectin‐SeNPs@Cur showed enhanced water solubility (∼500‐fold), dispersibility, and storage stability compared with those of free Cur. Moreover, pectin‐SeNPs@Cur possessed significant free radical scavenging ability and antioxidant capacity in vitro, which were stronger than those of pectin‐SeNPs. Antitumour activity assay in vitro demonstrated that pectin‐SeNPs@Cur could inhibit the growth of HepG2 cells in a concentration‐dependent manner, and the nanocarrier pectin‐SeNPs exhibited a low cytotoxic activity against HepG2 cells. Therefore, the results suggested that pectin‐SeNPs could function as effective nanovectors for the enhancement of the water solubility, stability, and in vitro bioactivities of hydrophobic Cur.https://doi.org/10.1049/iet-nbt.2019.0144pectin‐decorated selenium nanoparticlespectin‐stabilised selenium nanoparticlescurcumin encapsulationCur‐loaded pectin‐SeNPsnanocarrier pectin‐SeNPsphysicochemical properties |
| spellingShingle | Yan Wu Hong Liu Zhihua Li Dongye Huang Lizheng Nong Zhengxing Ning Zhizhong Hu Chunping Xu Jing‐Kun Yan Pectin‐decorated selenium nanoparticles as a nanocarrier of curcumin to achieve enhanced physicochemical and biological properties IET Nanobiotechnology pectin‐decorated selenium nanoparticles pectin‐stabilised selenium nanoparticles curcumin encapsulation Cur‐loaded pectin‐SeNPs nanocarrier pectin‐SeNPs physicochemical properties |
| title | Pectin‐decorated selenium nanoparticles as a nanocarrier of curcumin to achieve enhanced physicochemical and biological properties |
| title_full | Pectin‐decorated selenium nanoparticles as a nanocarrier of curcumin to achieve enhanced physicochemical and biological properties |
| title_fullStr | Pectin‐decorated selenium nanoparticles as a nanocarrier of curcumin to achieve enhanced physicochemical and biological properties |
| title_full_unstemmed | Pectin‐decorated selenium nanoparticles as a nanocarrier of curcumin to achieve enhanced physicochemical and biological properties |
| title_short | Pectin‐decorated selenium nanoparticles as a nanocarrier of curcumin to achieve enhanced physicochemical and biological properties |
| title_sort | pectin decorated selenium nanoparticles as a nanocarrier of curcumin to achieve enhanced physicochemical and biological properties |
| topic | pectin‐decorated selenium nanoparticles pectin‐stabilised selenium nanoparticles curcumin encapsulation Cur‐loaded pectin‐SeNPs nanocarrier pectin‐SeNPs physicochemical properties |
| url | https://doi.org/10.1049/iet-nbt.2019.0144 |
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