Exercise as a Mean to Control Low-Grade Systemic Inflammation
Chronic noncommunicable diseases (CNCDs), which include cardiovascular disease, some cancers, for example, colon cancer, breast cancer, and type 2 diabetes, are reaching epidemic proportions worldwide. It has now become clear that low-grade chronic inflammation is a key player in the pathogenesis of...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2008/109502 |
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| _version_ | 1832564179914981376 |
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| author | Neha Mathur Bente Klarlund Pedersen |
| author_facet | Neha Mathur Bente Klarlund Pedersen |
| author_sort | Neha Mathur |
| collection | DOAJ |
| description | Chronic noncommunicable diseases (CNCDs), which include cardiovascular disease, some cancers, for example, colon cancer, breast cancer, and type 2 diabetes, are reaching epidemic proportions worldwide. It has now become clear that low-grade chronic inflammation is a key player in the pathogenesis of most CNCDs. Given that regular exercise offers protection against all causes of mortality, primarily by protection against atherosclerosis and insulin resistance, we suggest that exercise may exert some of its beneficial health effects by inducing anti-inflammatory actions. Recently, IL-6 was introduced as the first myokine, defined as a cytokine, which is produced and released by contracting skeletal muscle fibres, exerting its effects in other organs of the body. We suggest that skeletal muscle is an endocrine organ and that myokines may be involved in mediating the beneficial effects against CNCDs associated with low-grade inflammation. |
| format | Article |
| id | doaj-art-299b6014fb1847b48f7c3be4ccf6ed85 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-299b6014fb1847b48f7c3be4ccf6ed852025-02-03T01:11:34ZengWileyMediators of Inflammation0962-93511466-18612008-01-01200810.1155/2008/109502109502Exercise as a Mean to Control Low-Grade Systemic InflammationNeha Mathur0Bente Klarlund Pedersen1The Centre of Inflammation and Metabolism (CIM), Department of Infectious Diseases and CMRC, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, DenmarkThe Centre of Inflammation and Metabolism (CIM), Department of Infectious Diseases and CMRC, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, DenmarkChronic noncommunicable diseases (CNCDs), which include cardiovascular disease, some cancers, for example, colon cancer, breast cancer, and type 2 diabetes, are reaching epidemic proportions worldwide. It has now become clear that low-grade chronic inflammation is a key player in the pathogenesis of most CNCDs. Given that regular exercise offers protection against all causes of mortality, primarily by protection against atherosclerosis and insulin resistance, we suggest that exercise may exert some of its beneficial health effects by inducing anti-inflammatory actions. Recently, IL-6 was introduced as the first myokine, defined as a cytokine, which is produced and released by contracting skeletal muscle fibres, exerting its effects in other organs of the body. We suggest that skeletal muscle is an endocrine organ and that myokines may be involved in mediating the beneficial effects against CNCDs associated with low-grade inflammation.http://dx.doi.org/10.1155/2008/109502 |
| spellingShingle | Neha Mathur Bente Klarlund Pedersen Exercise as a Mean to Control Low-Grade Systemic Inflammation Mediators of Inflammation |
| title | Exercise as a Mean to Control Low-Grade Systemic Inflammation |
| title_full | Exercise as a Mean to Control Low-Grade Systemic Inflammation |
| title_fullStr | Exercise as a Mean to Control Low-Grade Systemic Inflammation |
| title_full_unstemmed | Exercise as a Mean to Control Low-Grade Systemic Inflammation |
| title_short | Exercise as a Mean to Control Low-Grade Systemic Inflammation |
| title_sort | exercise as a mean to control low grade systemic inflammation |
| url | http://dx.doi.org/10.1155/2008/109502 |
| work_keys_str_mv | AT nehamathur exerciseasameantocontrollowgradesystemicinflammation AT benteklarlundpedersen exerciseasameantocontrollowgradesystemicinflammation |