Acute Effects of Ketamine Infusion on Postoperative Mood Scores in Patients Undergoing Dilation and Curettage: A Randomized Double-Blind Controlled Study
Background. Emotional and psychological effects following abortion are more common than physical side effects and can range from mild regret to more serious complications such as depression. In the last decade, it has been suggested that low dose of ketamine is a fast-acting antidepressant. Purpose....
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| Format: | Article |
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Wiley
2021-01-01
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| Series: | Anesthesiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2021/6674658 |
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| author | Raham Hasan Mostafa Ahmed Mohamed Khamis Ashraf Nabil Saleh Yehia Mamdouh Hassan Mekki Mohamed Mohamed Kamal Ismail Mohammed Ibrahim Mohamed Abdulmohsen Abdulnaiem Ismaiel |
| author_facet | Raham Hasan Mostafa Ahmed Mohamed Khamis Ashraf Nabil Saleh Yehia Mamdouh Hassan Mekki Mohamed Mohamed Kamal Ismail Mohammed Ibrahim Mohamed Abdulmohsen Abdulnaiem Ismaiel |
| author_sort | Raham Hasan Mostafa |
| collection | DOAJ |
| description | Background. Emotional and psychological effects following abortion are more common than physical side effects and can range from mild regret to more serious complications such as depression. In the last decade, it has been suggested that low dose of ketamine is a fast-acting antidepressant. Purpose. The aim of this study was to investigate the impact of intraoperative ketamine infusion on postoperative mood score in patients undergoing Dilation and Curettage (D&C) under spinal anesthesia. We hypothesized that a single low-dose administration of ketamine infusion during D&C surgery can improve mood scores in the immediate postoperative period. Methods. A prospective, randomized, double-blind, parallel-group, placebo-controlled trial. The study included a total of 60 patients, ≥18 years, physical status ASA II, with up to 12-week gestation undergoing elective D&C surgery. Patients were divided randomly into a ketamine group (group K) and a control group (group C). In group K, 0.4 mg/kg ketamine was given as a continuous infusion over 20 min intraoperatively. Main Outcome Measure. Profile of Mood States (POMS) was recorded preoperatively and 2 hours postoperatively. Results. There were no differences in preoperative POMS between the two groups. Mean postoperative POMS of group K was lower than that of group C indicating mood improvement. Ketamine group patients showed higher sedation score and increased, although self-limiting, psychedelic phenomena than the control group. Conclusion. Observed data here support an acute effect of ketamine on mood but any further claim will be speculative. Further future studies exploring postoperative mood scores after 24 hours post-infusion are needed. This trial is registered with PACTR201907779292947. |
| format | Article |
| id | doaj-art-298d6f2524a4489c81a992fd3b076821 |
| institution | Kabale University |
| issn | 1687-6962 1687-6970 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Anesthesiology Research and Practice |
| spelling | doaj-art-298d6f2524a4489c81a992fd3b0768212025-02-03T06:45:45ZengWileyAnesthesiology Research and Practice1687-69621687-69702021-01-01202110.1155/2021/66746586674658Acute Effects of Ketamine Infusion on Postoperative Mood Scores in Patients Undergoing Dilation and Curettage: A Randomized Double-Blind Controlled StudyRaham Hasan Mostafa0Ahmed Mohamed Khamis1Ashraf Nabil Saleh2Yehia Mamdouh Hassan Mekki3Mohamed Mohamed Kamal4Ismail Mohammed Ibrahim5Mohamed Abdulmohsen Abdulnaiem Ismaiel6Department of Anesthesia, Intensive Care and Pain Management, Ain Shams University, Cairo, EgyptDepartment of Anesthesia, Intensive Care and Pain Management, Ain Shams University, Cairo, EgyptDepartment of Anesthesia, Intensive Care and Pain Management, Ain Shams University, Cairo, EgyptDepartment of Anesthesia, Intensive Care and Pain Management, Ain Shams University, Cairo, EgyptDepartment of Anesthesia, Intensive Care and Pain Management, Ain Shams University, Cairo, EgyptDepartment of Anesthesia, Intensive Care and Pain Management, Ain Shams University, Cairo, EgyptDepartment of Anesthesia, Intensive Care and Pain Management, Ain Shams University, Cairo, EgyptBackground. Emotional and psychological effects following abortion are more common than physical side effects and can range from mild regret to more serious complications such as depression. In the last decade, it has been suggested that low dose of ketamine is a fast-acting antidepressant. Purpose. The aim of this study was to investigate the impact of intraoperative ketamine infusion on postoperative mood score in patients undergoing Dilation and Curettage (D&C) under spinal anesthesia. We hypothesized that a single low-dose administration of ketamine infusion during D&C surgery can improve mood scores in the immediate postoperative period. Methods. A prospective, randomized, double-blind, parallel-group, placebo-controlled trial. The study included a total of 60 patients, ≥18 years, physical status ASA II, with up to 12-week gestation undergoing elective D&C surgery. Patients were divided randomly into a ketamine group (group K) and a control group (group C). In group K, 0.4 mg/kg ketamine was given as a continuous infusion over 20 min intraoperatively. Main Outcome Measure. Profile of Mood States (POMS) was recorded preoperatively and 2 hours postoperatively. Results. There were no differences in preoperative POMS between the two groups. Mean postoperative POMS of group K was lower than that of group C indicating mood improvement. Ketamine group patients showed higher sedation score and increased, although self-limiting, psychedelic phenomena than the control group. Conclusion. Observed data here support an acute effect of ketamine on mood but any further claim will be speculative. Further future studies exploring postoperative mood scores after 24 hours post-infusion are needed. This trial is registered with PACTR201907779292947.http://dx.doi.org/10.1155/2021/6674658 |
| spellingShingle | Raham Hasan Mostafa Ahmed Mohamed Khamis Ashraf Nabil Saleh Yehia Mamdouh Hassan Mekki Mohamed Mohamed Kamal Ismail Mohammed Ibrahim Mohamed Abdulmohsen Abdulnaiem Ismaiel Acute Effects of Ketamine Infusion on Postoperative Mood Scores in Patients Undergoing Dilation and Curettage: A Randomized Double-Blind Controlled Study Anesthesiology Research and Practice |
| title | Acute Effects of Ketamine Infusion on Postoperative Mood Scores in Patients Undergoing Dilation and Curettage: A Randomized Double-Blind Controlled Study |
| title_full | Acute Effects of Ketamine Infusion on Postoperative Mood Scores in Patients Undergoing Dilation and Curettage: A Randomized Double-Blind Controlled Study |
| title_fullStr | Acute Effects of Ketamine Infusion on Postoperative Mood Scores in Patients Undergoing Dilation and Curettage: A Randomized Double-Blind Controlled Study |
| title_full_unstemmed | Acute Effects of Ketamine Infusion on Postoperative Mood Scores in Patients Undergoing Dilation and Curettage: A Randomized Double-Blind Controlled Study |
| title_short | Acute Effects of Ketamine Infusion on Postoperative Mood Scores in Patients Undergoing Dilation and Curettage: A Randomized Double-Blind Controlled Study |
| title_sort | acute effects of ketamine infusion on postoperative mood scores in patients undergoing dilation and curettage a randomized double blind controlled study |
| url | http://dx.doi.org/10.1155/2021/6674658 |
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