Antibacterial Activity of Grepafloxacin
Grepafloxin has an extremely broad spectrum of activity. Its activity against Gram-positive bacteria exceeds that of currently available quinolones. Grepafloxacin-resistant mutants seem to occur less frequently than ciprofloxacin - or ofloxacin-resistant mutants, and the increase in minimum inhibito...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1998-01-01
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| Series: | Canadian Journal of Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/1998/915401 |
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| _version_ | 1832556244324319232 |
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| author | B Wiedemann P Heisig |
| author_facet | B Wiedemann P Heisig |
| author_sort | B Wiedemann |
| collection | DOAJ |
| description | Grepafloxin has an extremely broad spectrum of activity. Its activity against Gram-positive bacteria exceeds that of currently available quinolones. Grepafloxacin-resistant mutants seem to occur less frequently than ciprofloxacin - or ofloxacin-resistant mutants, and the increase in minimum inhibitory concentration (MIC) against the former mutants is less than that of the latter. This applies only to the relative differences (in dilution steps); the absolute values are similar. Grepafloxacin kills Gram-positive bacteria at concentrations little above the MIC. Its pharmacodynamic profile against pneumococci is promising, favouring use of this drug for respiratory tract infections. |
| format | Article |
| id | doaj-art-29886ab0435d48afbf0f3efb4e40c4ee |
| institution | Kabale University |
| issn | 1180-2332 |
| language | English |
| publishDate | 1998-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases |
| spelling | doaj-art-29886ab0435d48afbf0f3efb4e40c4ee2025-02-03T05:45:58ZengWileyCanadian Journal of Infectious Diseases1180-23321998-01-019Suppl E4E9E10.1155/1998/915401Antibacterial Activity of GrepafloxacinB Wiedemann0P Heisig1Pharmaceucica/Aticrobiology, University of Bonn, Meckenheimer Allee 168, D-53115 Bonn, GermanyPharmaceucica/Aticrobiology, University of Bonn, Meckenheimer Allee 168, D-53115 Bonn, GermanyGrepafloxin has an extremely broad spectrum of activity. Its activity against Gram-positive bacteria exceeds that of currently available quinolones. Grepafloxacin-resistant mutants seem to occur less frequently than ciprofloxacin - or ofloxacin-resistant mutants, and the increase in minimum inhibitory concentration (MIC) against the former mutants is less than that of the latter. This applies only to the relative differences (in dilution steps); the absolute values are similar. Grepafloxacin kills Gram-positive bacteria at concentrations little above the MIC. Its pharmacodynamic profile against pneumococci is promising, favouring use of this drug for respiratory tract infections.http://dx.doi.org/10.1155/1998/915401 |
| spellingShingle | B Wiedemann P Heisig Antibacterial Activity of Grepafloxacin Canadian Journal of Infectious Diseases |
| title | Antibacterial Activity of Grepafloxacin |
| title_full | Antibacterial Activity of Grepafloxacin |
| title_fullStr | Antibacterial Activity of Grepafloxacin |
| title_full_unstemmed | Antibacterial Activity of Grepafloxacin |
| title_short | Antibacterial Activity of Grepafloxacin |
| title_sort | antibacterial activity of grepafloxacin |
| url | http://dx.doi.org/10.1155/1998/915401 |
| work_keys_str_mv | AT bwiedemann antibacterialactivityofgrepafloxacin AT pheisig antibacterialactivityofgrepafloxacin |