Comparative evaluation of ondansetron, palonosetron, and dexamethasone for antiemetic prophylaxis in cesarean section under spinal anaesthesia
Background: Spinal anesthesia is the most common regional anesthesia used to provide surgical anesthesia for cesarean section. Nausea and vomiting are common symptoms experienced by patients undergoing cesarean section. Aims and Objectives: The aim of this study was to assess and compare the effi...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2025-02-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://ajmsjournal.info/index.php/AJMS/article/view/4394 |
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| author | Vankudoth Bhaskar Jitendra Agrawal Ankita Gupta Ashish Mohan M |
| author_facet | Vankudoth Bhaskar Jitendra Agrawal Ankita Gupta Ashish Mohan M |
| author_sort | Vankudoth Bhaskar |
| collection | DOAJ |
| description | Background: Spinal anesthesia is the most common regional anesthesia used to provide surgical anesthesia for cesarean section. Nausea and vomiting are common symptoms experienced by patients undergoing cesarean section.
Aims and Objectives: The aim of this study was to assess and compare the efficacy of dexamethasone, ondansetron, and palonosetron in prevention of nausea and vomiting.
Materials and Methods: This prospective randomized study was conducted on total 90 patients undergoing cesarean section, divided in three groups of 30 patients each. Group O received 4 mg ondansetron i.v., Group P received palonosetron 075 mg i.v and Group D received 8 mg dexamethasone i.v. The incidence of nausea and vomiting was compared between the groups and side effects were assessed.
Results: Antiemetic prophylaxis reduced the overall incidence of nausea and vomiting. However, Palonosetron had a lower incidence of nausea and vomiting as compared to dexamethasone and ondansetron.
Conclusion: Our study concluded that Palonosetron had the lowest incidence of nausea and vomiting. |
| format | Article |
| id | doaj-art-298181b37e8c4b839343e4b6098d15f4 |
| institution | Kabale University |
| issn | 2467-9100 2091-0576 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj-art-298181b37e8c4b839343e4b6098d15f42025-02-01T08:19:34ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762025-02-011623844https://doi.org/10.71152/ajms.v16i2.4394Comparative evaluation of ondansetron, palonosetron, and dexamethasone for antiemetic prophylaxis in cesarean section under spinal anaesthesiaVankudoth Bhaskar 0https://orcid.org/0009-0006-8387-9998Jitendra Agrawal 1https://orcid.org/0009-0001-2470-4761Ankita Gupta 2https://orcid.org/0000-0002-3303-988XAshish Mohan M3https://orcid.org/0009-0004-7660-1141Postgraduate Resident, Department of Anaesthesiology, Gajra Raja Medical College, Gwalior, Madhya Pradesh, India Professor, Department of Anaesthesiology, Gajra Raja Medical College, Gwalior, Madhya Pradesh, India Former Senior Resident, Department of Anaesthesiology, Gajra Raja Medical College, Gwalior, Madhya Pradesh, India Postgraduate Resident, Department of Anaesthesiology, Gajra Raja Medical College, Gwalior, Madhya Pradesh, India Background: Spinal anesthesia is the most common regional anesthesia used to provide surgical anesthesia for cesarean section. Nausea and vomiting are common symptoms experienced by patients undergoing cesarean section. Aims and Objectives: The aim of this study was to assess and compare the efficacy of dexamethasone, ondansetron, and palonosetron in prevention of nausea and vomiting. Materials and Methods: This prospective randomized study was conducted on total 90 patients undergoing cesarean section, divided in three groups of 30 patients each. Group O received 4 mg ondansetron i.v., Group P received palonosetron 075 mg i.v and Group D received 8 mg dexamethasone i.v. The incidence of nausea and vomiting was compared between the groups and side effects were assessed. Results: Antiemetic prophylaxis reduced the overall incidence of nausea and vomiting. However, Palonosetron had a lower incidence of nausea and vomiting as compared to dexamethasone and ondansetron. Conclusion: Our study concluded that Palonosetron had the lowest incidence of nausea and vomiting.https://ajmsjournal.info/index.php/AJMS/article/view/4394ondansetron; palonosetron; dexamethasone; cesarean section |
| spellingShingle | Vankudoth Bhaskar Jitendra Agrawal Ankita Gupta Ashish Mohan M Comparative evaluation of ondansetron, palonosetron, and dexamethasone for antiemetic prophylaxis in cesarean section under spinal anaesthesia Asian Journal of Medical Sciences ondansetron; palonosetron; dexamethasone; cesarean section |
| title | Comparative evaluation of ondansetron, palonosetron, and dexamethasone for antiemetic prophylaxis in cesarean section under spinal anaesthesia |
| title_full | Comparative evaluation of ondansetron, palonosetron, and dexamethasone for antiemetic prophylaxis in cesarean section under spinal anaesthesia |
| title_fullStr | Comparative evaluation of ondansetron, palonosetron, and dexamethasone for antiemetic prophylaxis in cesarean section under spinal anaesthesia |
| title_full_unstemmed | Comparative evaluation of ondansetron, palonosetron, and dexamethasone for antiemetic prophylaxis in cesarean section under spinal anaesthesia |
| title_short | Comparative evaluation of ondansetron, palonosetron, and dexamethasone for antiemetic prophylaxis in cesarean section under spinal anaesthesia |
| title_sort | comparative evaluation of ondansetron palonosetron and dexamethasone for antiemetic prophylaxis in cesarean section under spinal anaesthesia |
| topic | ondansetron; palonosetron; dexamethasone; cesarean section |
| url | https://ajmsjournal.info/index.php/AJMS/article/view/4394 |
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