Role of Natural Radiosensitizers and Cancer Cell Radioresistance: An Update
Cancer originates from genetic mutations accumulation. Cancer stem cells have been depicted as tumorigenic cells that can differentiate and self-renew. Cancer stem cells are thought to be resistant to conventional therapy like chemotherapy and radiation therapy. Radiation therapy and chemotherapy da...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2016/6146595 |
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| author | Arif Malik Misbah Sultana Aamer Qazi Mahmood Husain Qazi Gulshan Parveen Sulayman Waquar Abdul Basit Ashraf Mahmood Rasool |
| author_facet | Arif Malik Misbah Sultana Aamer Qazi Mahmood Husain Qazi Gulshan Parveen Sulayman Waquar Abdul Basit Ashraf Mahmood Rasool |
| author_sort | Arif Malik |
| collection | DOAJ |
| description | Cancer originates from genetic mutations accumulation. Cancer stem cells have been depicted as tumorigenic cells that can differentiate and self-renew. Cancer stem cells are thought to be resistant to conventional therapy like chemotherapy and radiation therapy. Radiation therapy and chemotherapy damage carcinomic DNA cells. Because of the ability of cancer stem cells to self-renew and reproduce malignant tumors, they are the subject of intensive research. In this review, CSCs radioresistant mechanisms which include DNA damage response and natural radiosensitizers have been summed up. Reactive oxygen species play an important role in different physiological processes. ROS scavenging is responsible for regulation of reactive oxygen species generation. A researcher has proved that microRNAs regulate tumor radiation resistance. Ionizing radiation does not kill the cancer cells; rather, IR just slows down the signs and symptoms. Ionizing radiation damages DNA directly/indirectly. IR is given mostly in combination with other chemo/radiotherapies. We briefly described here the behavior of cancer stem cells and radioresistance therapies in cancer treatment. To overcome radioresistance in treatment of cancer, strategies like fractionation modification, treatment in combination, inflammation modification, and overcoming hypoxic tumor have been practiced. Natural radiosensitizers, for example, curcumin, genistein, and quercetin, are more beneficial than synthetic compounds. |
| format | Article |
| id | doaj-art-2967825ec3ec491ea77d1c7327c4e97a |
| institution | Kabale University |
| issn | 2210-7177 2210-7185 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-2967825ec3ec491ea77d1c7327c4e97a2025-02-03T05:52:24ZengWileyAnalytical Cellular Pathology2210-71772210-71852016-01-01201610.1155/2016/61465956146595Role of Natural Radiosensitizers and Cancer Cell Radioresistance: An UpdateArif Malik0Misbah Sultana1Aamer Qazi2Mahmood Husain Qazi3Gulshan Parveen4Sulayman Waquar5Abdul Basit Ashraf6Mahmood Rasool7Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, PakistanInstitute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, PakistanCenter for Research in Molecular Medicine (CRiMM), The University of Lahore, PakistanCenter for Research in Molecular Medicine (CRiMM), The University of Lahore, PakistanInstitute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, PakistanInstitute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, PakistanUniversity College of Medicine and Dentistry, The University of Lahore, PakistanCenter of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, Jeddah, Saudi ArabiaCancer originates from genetic mutations accumulation. Cancer stem cells have been depicted as tumorigenic cells that can differentiate and self-renew. Cancer stem cells are thought to be resistant to conventional therapy like chemotherapy and radiation therapy. Radiation therapy and chemotherapy damage carcinomic DNA cells. Because of the ability of cancer stem cells to self-renew and reproduce malignant tumors, they are the subject of intensive research. In this review, CSCs radioresistant mechanisms which include DNA damage response and natural radiosensitizers have been summed up. Reactive oxygen species play an important role in different physiological processes. ROS scavenging is responsible for regulation of reactive oxygen species generation. A researcher has proved that microRNAs regulate tumor radiation resistance. Ionizing radiation does not kill the cancer cells; rather, IR just slows down the signs and symptoms. Ionizing radiation damages DNA directly/indirectly. IR is given mostly in combination with other chemo/radiotherapies. We briefly described here the behavior of cancer stem cells and radioresistance therapies in cancer treatment. To overcome radioresistance in treatment of cancer, strategies like fractionation modification, treatment in combination, inflammation modification, and overcoming hypoxic tumor have been practiced. Natural radiosensitizers, for example, curcumin, genistein, and quercetin, are more beneficial than synthetic compounds.http://dx.doi.org/10.1155/2016/6146595 |
| spellingShingle | Arif Malik Misbah Sultana Aamer Qazi Mahmood Husain Qazi Gulshan Parveen Sulayman Waquar Abdul Basit Ashraf Mahmood Rasool Role of Natural Radiosensitizers and Cancer Cell Radioresistance: An Update Analytical Cellular Pathology |
| title | Role of Natural Radiosensitizers and Cancer Cell Radioresistance: An Update |
| title_full | Role of Natural Radiosensitizers and Cancer Cell Radioresistance: An Update |
| title_fullStr | Role of Natural Radiosensitizers and Cancer Cell Radioresistance: An Update |
| title_full_unstemmed | Role of Natural Radiosensitizers and Cancer Cell Radioresistance: An Update |
| title_short | Role of Natural Radiosensitizers and Cancer Cell Radioresistance: An Update |
| title_sort | role of natural radiosensitizers and cancer cell radioresistance an update |
| url | http://dx.doi.org/10.1155/2016/6146595 |
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