Solitary Lytic Bone Metastasis: A Rare Presentation of Small Lymphocytic Leukemia
Chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) is a hematologic malignancy characterized by an over accumulation of incompetent neoplastic lymphocytes. Bone metastasis in CLL/SLL is very rare. We report a case of a 76-year-old Caucasian female presented with an unresolving pulmo...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2018/6154709 |
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| author | Heather Katz Steven Sagun Doreen Griswold Mohamed Alsharedi |
| author_facet | Heather Katz Steven Sagun Doreen Griswold Mohamed Alsharedi |
| author_sort | Heather Katz |
| collection | DOAJ |
| description | Chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) is a hematologic malignancy characterized by an over accumulation of incompetent neoplastic lymphocytes. Bone metastasis in CLL/SLL is very rare. We report a case of a 76-year-old Caucasian female presented with an unresolving pulmonary infiltrate with mediastinal lymphadenopathy concerning for malignancy. Positron emission tomography (PET)/computed tomography (CT) showed an infiltrative mass in the mediastinum with diffuse uptake and a hypermetabolic mass within the left iliac bone. Transbronchial biopsy revealed morphology and features of SLL. However, with concern for another primary cancer, a CT-guided biopsy of the PET avid left iliac bone was performed and revealed bone and marrow with involvement of CLL/SLL similar to the chest lymphadenopathy. To our knowledge and after extensive review of medical literature, this is first reported case of SLL with solitary bone metastasis to the hip. |
| format | Article |
| id | doaj-art-2953e5784e414eb1a4b46b194016f1bd |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-2953e5784e414eb1a4b46b194016f1bd2025-02-03T01:10:54ZengWileyCase Reports in Hematology2090-65602090-65792018-01-01201810.1155/2018/61547096154709Solitary Lytic Bone Metastasis: A Rare Presentation of Small Lymphocytic LeukemiaHeather Katz0Steven Sagun1Doreen Griswold2Mohamed Alsharedi3Department of Hematology/Oncology, Joan C. Edwards School of Medicine Marshall University, 1600 Medical Center Dr, Huntington, WV 25701, USAJoan C. Edwards School of Medicine Marshall University, 1600 Medical Center Dr, Huntington, WV 25701, USADepartment of Pathology, Joan C. Edwards School of Medicine Marshall University, 1600 Medical Center Dr, Huntington, WV 25701, USADepartment of Hematology/Oncology, Joan C. Edwards School of Medicine Marshall University, 1600 Medical Center Dr, Huntington, WV 25701, USAChronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) is a hematologic malignancy characterized by an over accumulation of incompetent neoplastic lymphocytes. Bone metastasis in CLL/SLL is very rare. We report a case of a 76-year-old Caucasian female presented with an unresolving pulmonary infiltrate with mediastinal lymphadenopathy concerning for malignancy. Positron emission tomography (PET)/computed tomography (CT) showed an infiltrative mass in the mediastinum with diffuse uptake and a hypermetabolic mass within the left iliac bone. Transbronchial biopsy revealed morphology and features of SLL. However, with concern for another primary cancer, a CT-guided biopsy of the PET avid left iliac bone was performed and revealed bone and marrow with involvement of CLL/SLL similar to the chest lymphadenopathy. To our knowledge and after extensive review of medical literature, this is first reported case of SLL with solitary bone metastasis to the hip.http://dx.doi.org/10.1155/2018/6154709 |
| spellingShingle | Heather Katz Steven Sagun Doreen Griswold Mohamed Alsharedi Solitary Lytic Bone Metastasis: A Rare Presentation of Small Lymphocytic Leukemia Case Reports in Hematology |
| title | Solitary Lytic Bone Metastasis: A Rare Presentation of Small Lymphocytic Leukemia |
| title_full | Solitary Lytic Bone Metastasis: A Rare Presentation of Small Lymphocytic Leukemia |
| title_fullStr | Solitary Lytic Bone Metastasis: A Rare Presentation of Small Lymphocytic Leukemia |
| title_full_unstemmed | Solitary Lytic Bone Metastasis: A Rare Presentation of Small Lymphocytic Leukemia |
| title_short | Solitary Lytic Bone Metastasis: A Rare Presentation of Small Lymphocytic Leukemia |
| title_sort | solitary lytic bone metastasis a rare presentation of small lymphocytic leukemia |
| url | http://dx.doi.org/10.1155/2018/6154709 |
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