Hyaluronic Acid-Based Drug Delivery Systems for Cancer Therapy
In recent years, hyaluronic acid (HA) has attracted increasing attention as a promising biomaterial for the development of drug delivery systems. Due to its unique properties, such as high biocompatibility, low toxicity, and modifiability, HA is becoming a basis for the creation of targeted drug del...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/14/2/61 |
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| author | Ekaterina Pashkina Maria Bykova Maria Berishvili Yaroslav Lazarev Vladimir Kozlov |
| author_facet | Ekaterina Pashkina Maria Bykova Maria Berishvili Yaroslav Lazarev Vladimir Kozlov |
| author_sort | Ekaterina Pashkina |
| collection | DOAJ |
| description | In recent years, hyaluronic acid (HA) has attracted increasing attention as a promising biomaterial for the development of drug delivery systems. Due to its unique properties, such as high biocompatibility, low toxicity, and modifiability, HA is becoming a basis for the creation of targeted drug delivery systems, especially in the field of oncology. Receptors for HA overexpressed in subpopulations of cancer cells, and one of them, CD44, is recognized as a molecular marker for cancer stem cells. This review examines the role of HA and its receptors in health and tumors and analyzes existing HA-based delivery systems and their use in various types of cancer. The development of new HA-based drug delivery systems will bring new opportunities and challenges to anti-cancer therapy. |
| format | Article |
| id | doaj-art-294e3486323645048f665da45005375d |
| institution | Kabale University |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-294e3486323645048f665da45005375d2025-01-24T13:26:32ZengMDPI AGCells2073-44092025-01-011426110.3390/cells14020061Hyaluronic Acid-Based Drug Delivery Systems for Cancer TherapyEkaterina Pashkina0Maria Bykova1Maria Berishvili2Yaroslav Lazarev3Vladimir Kozlov4Research Institute of Fundamental and Clinical Immunology, 14, Yadrintsevskaya St., 630099 Novosibirsk, RussiaResearch Institute of Fundamental and Clinical Immunology, 14, Yadrintsevskaya St., 630099 Novosibirsk, RussiaResearch Institute of Fundamental and Clinical Immunology, 14, Yadrintsevskaya St., 630099 Novosibirsk, RussiaResearch Institute of Fundamental and Clinical Immunology, 14, Yadrintsevskaya St., 630099 Novosibirsk, RussiaResearch Institute of Fundamental and Clinical Immunology, 14, Yadrintsevskaya St., 630099 Novosibirsk, RussiaIn recent years, hyaluronic acid (HA) has attracted increasing attention as a promising biomaterial for the development of drug delivery systems. Due to its unique properties, such as high biocompatibility, low toxicity, and modifiability, HA is becoming a basis for the creation of targeted drug delivery systems, especially in the field of oncology. Receptors for HA overexpressed in subpopulations of cancer cells, and one of them, CD44, is recognized as a molecular marker for cancer stem cells. This review examines the role of HA and its receptors in health and tumors and analyzes existing HA-based delivery systems and their use in various types of cancer. The development of new HA-based drug delivery systems will bring new opportunities and challenges to anti-cancer therapy.https://www.mdpi.com/2073-4409/14/2/61hyaluronic acidextracellular matrixdrug delivery systemnanoparticlecancer therapysupramolecular system |
| spellingShingle | Ekaterina Pashkina Maria Bykova Maria Berishvili Yaroslav Lazarev Vladimir Kozlov Hyaluronic Acid-Based Drug Delivery Systems for Cancer Therapy Cells hyaluronic acid extracellular matrix drug delivery system nanoparticle cancer therapy supramolecular system |
| title | Hyaluronic Acid-Based Drug Delivery Systems for Cancer Therapy |
| title_full | Hyaluronic Acid-Based Drug Delivery Systems for Cancer Therapy |
| title_fullStr | Hyaluronic Acid-Based Drug Delivery Systems for Cancer Therapy |
| title_full_unstemmed | Hyaluronic Acid-Based Drug Delivery Systems for Cancer Therapy |
| title_short | Hyaluronic Acid-Based Drug Delivery Systems for Cancer Therapy |
| title_sort | hyaluronic acid based drug delivery systems for cancer therapy |
| topic | hyaluronic acid extracellular matrix drug delivery system nanoparticle cancer therapy supramolecular system |
| url | https://www.mdpi.com/2073-4409/14/2/61 |
| work_keys_str_mv | AT ekaterinapashkina hyaluronicacidbaseddrugdeliverysystemsforcancertherapy AT mariabykova hyaluronicacidbaseddrugdeliverysystemsforcancertherapy AT mariaberishvili hyaluronicacidbaseddrugdeliverysystemsforcancertherapy AT yaroslavlazarev hyaluronicacidbaseddrugdeliverysystemsforcancertherapy AT vladimirkozlov hyaluronicacidbaseddrugdeliverysystemsforcancertherapy |