Association of Plasma Circulatory Markers, Chlamydia pneumoniae, and High Sensitive C-Reactive Protein in Coronary Artery Disease Patients of India
Plasma inflammatory markers have been shown to be predictors for cardiovascular risk, however, there is no study where the levels of plasma circulatory markers have been evaluated in coronary artery disease patients (CAD pts) positive for C. pneumoniae IgA and high sensitive C-reactive protein (hsCR...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2009/561532 |
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| author | Hem Chandra Jha Pragya Srivastava Rakesh Sarkar Jagdish Prasad Aruna Singh Mittal |
| author_facet | Hem Chandra Jha Pragya Srivastava Rakesh Sarkar Jagdish Prasad Aruna Singh Mittal |
| author_sort | Hem Chandra Jha |
| collection | DOAJ |
| description | Plasma inflammatory markers have been shown to be predictors for cardiovascular risk, however, there is no study where the levels of plasma circulatory markers have been evaluated in coronary artery disease patients (CAD pts) positive for C. pneumoniae IgA and high sensitive C-reactive protein (hsCRP) which may help in better understanding of disease pathogenesis. A total of 192 patients and 192 controls attending the Cardiology Outpatient Department of Safdarjung Hospital were enrolled. The levels of plasma circulatory inflammatory markers were evaluated by ELISA. The levels of circulatory plasma markers (IL-4, IL-8, IL-13, ICAM-1, and VCAM-1) were significantly higher, whereas, levels of IL-10 and IFN-γ
were significantly lower in CAD pts compared to healthy controls. The levels of IL-4, IL-8, and ICAM-1 (P=.007, .015, and .048) were significantly higher, however, IL-10 and IFN-γ
were significantly lower (P<.001, <.001) in C. pneumoniae IgA positive CAD pts. The levels of IL-4, IL-8, IL-13, ICAM-1, and VCAM-1 were higher but not significant and levels of IL-10 and IFN-γ
were significantly (P<.001, <.001) lower in hsCRP positive CAD pts. Our study suggested that circulatory cytokines, namely, IL-4, IL-8, and adhesive molecules like ICAM-1 were enhanced after infection with C. pneumoniae whereas in contrast to this IL-10 and IFN-λ
were lowered. Suggesting the important role of these cytokines in progression of CAD. |
| format | Article |
| id | doaj-art-2949a6c9d787402d97550d6b3443f74f |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-2949a6c9d787402d97550d6b3443f74f2025-02-03T05:58:17ZengWileyMediators of Inflammation0962-93511466-18612009-01-01200910.1155/2009/561532561532Association of Plasma Circulatory Markers, Chlamydia pneumoniae, and High Sensitive C-Reactive Protein in Coronary Artery Disease Patients of IndiaHem Chandra Jha0Pragya Srivastava1Rakesh Sarkar2Jagdish Prasad3Aruna Singh Mittal4Institute of Pathology (ICMR), Safdarjung Hospital Campus, P.O. Box 4909, New Delhi 110 029, IndiaInstitute of Pathology (ICMR), Safdarjung Hospital Campus, P.O. Box 4909, New Delhi 110 029, IndiaInstitute of Pathology (ICMR), Safdarjung Hospital Campus, P.O. Box 4909, New Delhi 110 029, IndiaDepartment of Cardio Thoracic & Vascular Surgery, Safdarjung Hospital, New Delhi 110 029, IndiaInstitute of Pathology (ICMR), Safdarjung Hospital Campus, P.O. Box 4909, New Delhi 110 029, IndiaPlasma inflammatory markers have been shown to be predictors for cardiovascular risk, however, there is no study where the levels of plasma circulatory markers have been evaluated in coronary artery disease patients (CAD pts) positive for C. pneumoniae IgA and high sensitive C-reactive protein (hsCRP) which may help in better understanding of disease pathogenesis. A total of 192 patients and 192 controls attending the Cardiology Outpatient Department of Safdarjung Hospital were enrolled. The levels of plasma circulatory inflammatory markers were evaluated by ELISA. The levels of circulatory plasma markers (IL-4, IL-8, IL-13, ICAM-1, and VCAM-1) were significantly higher, whereas, levels of IL-10 and IFN-γ were significantly lower in CAD pts compared to healthy controls. The levels of IL-4, IL-8, and ICAM-1 (P=.007, .015, and .048) were significantly higher, however, IL-10 and IFN-γ were significantly lower (P<.001, <.001) in C. pneumoniae IgA positive CAD pts. The levels of IL-4, IL-8, IL-13, ICAM-1, and VCAM-1 were higher but not significant and levels of IL-10 and IFN-γ were significantly (P<.001, <.001) lower in hsCRP positive CAD pts. Our study suggested that circulatory cytokines, namely, IL-4, IL-8, and adhesive molecules like ICAM-1 were enhanced after infection with C. pneumoniae whereas in contrast to this IL-10 and IFN-λ were lowered. Suggesting the important role of these cytokines in progression of CAD.http://dx.doi.org/10.1155/2009/561532 |
| spellingShingle | Hem Chandra Jha Pragya Srivastava Rakesh Sarkar Jagdish Prasad Aruna Singh Mittal Association of Plasma Circulatory Markers, Chlamydia pneumoniae, and High Sensitive C-Reactive Protein in Coronary Artery Disease Patients of India Mediators of Inflammation |
| title | Association of Plasma Circulatory Markers,
Chlamydia pneumoniae, and High Sensitive C-Reactive Protein in Coronary Artery Disease Patients of India |
| title_full | Association of Plasma Circulatory Markers,
Chlamydia pneumoniae, and High Sensitive C-Reactive Protein in Coronary Artery Disease Patients of India |
| title_fullStr | Association of Plasma Circulatory Markers,
Chlamydia pneumoniae, and High Sensitive C-Reactive Protein in Coronary Artery Disease Patients of India |
| title_full_unstemmed | Association of Plasma Circulatory Markers,
Chlamydia pneumoniae, and High Sensitive C-Reactive Protein in Coronary Artery Disease Patients of India |
| title_short | Association of Plasma Circulatory Markers,
Chlamydia pneumoniae, and High Sensitive C-Reactive Protein in Coronary Artery Disease Patients of India |
| title_sort | association of plasma circulatory markers chlamydia pneumoniae and high sensitive c reactive protein in coronary artery disease patients of india |
| url | http://dx.doi.org/10.1155/2009/561532 |
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