LLT1 overexpression renders allogeneic-NK resistance and facilitates the generation of enhanced universal CAR-T cells

LLT1 overexpression renders allogeneic-NK resistance and facilitates the generation of enhanced universal CAR-T cells

Abstract Background The benefit of universal CAR-T cells over autologous CAR-T cell therapy is that they are a treatment that is ready to use. However, the prevention of graft-versus-host disease (GVHD) and host-versus-graft reaction (HVGR) remains challenging. Deleting class I of human leukocyte an...

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Bibliographic Details
Main Authors: Shuxian Zhu, Shiyu Zuo, Chuo Li, Xingjie You, Erlie Jiang, Xiaoming Feng, Yuechen Luo
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Universal CAR-T Cells
NK Cell Inhibition
Allogeneic Rejection
T Cell Stemness
Online Access:https://doi.org/10.1186/s13046-025-03273-2
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