Imprinting and Promoter Usage of Insulin-Like Growth Factor II in Twin Discordant Placenta
Case reports from infant twins suggest that abnormal genomic imprinting may be one of the important causes of twin discordance, but it is unknown whether abnormal genomic imprinting occurs in the placenta. Therefore, we sought to determine the relationship between the imprinting of insulin-like grow...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2010/498574 |
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| author | Yan-Min Luo Qun Fang Hui-Juan Shi Lin-Huan Huang Run-Cai Liang Guang-Lun Zhuang |
| author_facet | Yan-Min Luo Qun Fang Hui-Juan Shi Lin-Huan Huang Run-Cai Liang Guang-Lun Zhuang |
| author_sort | Yan-Min Luo |
| collection | DOAJ |
| description | Case reports from infant twins suggest that abnormal genomic imprinting may be one of the important causes of twin discordance, but it is unknown whether abnormal genomic imprinting occurs in the placenta. Therefore, we sought to determine the relationship between the imprinting of insulin-like growth factor II (IGF-II) in placenta and twin discordance. We analyzed the imprinting and promoter usage of IGF-II in placenta of normal twins (T0 group), weight discordance (T1 group), and phenotype discordance (T2 group). We found the incidence of loss of imprinting (LOI) for IGF-II was higher in the T2 group than that in the T0 and T1 groups, while there was no difference between T0 and T1 groups. The transcripts of promoter 3 were lower in the T2 group than in the T0 and T1 groups, and lower in the twin placenta with LOI than in those with normal imprinting. Our findings indicate that the promoter 3 specific LOI of the IGF-II gene may be closely related with phenotype discordance, not weight discordance. |
| format | Article |
| id | doaj-art-293e6127f52949f4a32dab8adf48b9b1 |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-293e6127f52949f4a32dab8adf48b9b12025-02-03T01:26:44ZengWileyObstetrics and Gynecology International1687-95891687-95972010-01-01201010.1155/2010/498574498574Imprinting and Promoter Usage of Insulin-Like Growth Factor II in Twin Discordant PlacentaYan-Min Luo0Qun Fang1Hui-Juan Shi2Lin-Huan Huang3Run-Cai Liang4Guang-Lun Zhuang5Fetal Medicine Center, Department of Obstetrics and Gynecology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, ChinaFetal Medicine Center, Department of Obstetrics and Gynecology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, ChinaDepartment of Pathology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, ChinaFetal Medicine Center, Department of Obstetrics and Gynecology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, ChinaDepartment of Obstetrics and Gynecology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, ChinaDepartment of Obstetrics and Gynecology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, ChinaCase reports from infant twins suggest that abnormal genomic imprinting may be one of the important causes of twin discordance, but it is unknown whether abnormal genomic imprinting occurs in the placenta. Therefore, we sought to determine the relationship between the imprinting of insulin-like growth factor II (IGF-II) in placenta and twin discordance. We analyzed the imprinting and promoter usage of IGF-II in placenta of normal twins (T0 group), weight discordance (T1 group), and phenotype discordance (T2 group). We found the incidence of loss of imprinting (LOI) for IGF-II was higher in the T2 group than that in the T0 and T1 groups, while there was no difference between T0 and T1 groups. The transcripts of promoter 3 were lower in the T2 group than in the T0 and T1 groups, and lower in the twin placenta with LOI than in those with normal imprinting. Our findings indicate that the promoter 3 specific LOI of the IGF-II gene may be closely related with phenotype discordance, not weight discordance.http://dx.doi.org/10.1155/2010/498574 |
| spellingShingle | Yan-Min Luo Qun Fang Hui-Juan Shi Lin-Huan Huang Run-Cai Liang Guang-Lun Zhuang Imprinting and Promoter Usage of Insulin-Like Growth Factor II in Twin Discordant Placenta Obstetrics and Gynecology International |
| title | Imprinting and Promoter Usage of Insulin-Like Growth Factor II in Twin Discordant Placenta |
| title_full | Imprinting and Promoter Usage of Insulin-Like Growth Factor II in Twin Discordant Placenta |
| title_fullStr | Imprinting and Promoter Usage of Insulin-Like Growth Factor II in Twin Discordant Placenta |
| title_full_unstemmed | Imprinting and Promoter Usage of Insulin-Like Growth Factor II in Twin Discordant Placenta |
| title_short | Imprinting and Promoter Usage of Insulin-Like Growth Factor II in Twin Discordant Placenta |
| title_sort | imprinting and promoter usage of insulin like growth factor ii in twin discordant placenta |
| url | http://dx.doi.org/10.1155/2010/498574 |
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