Dihydromyricetin Inhibits M1 Macrophage Polarization in Atherosclerosis by Modulating miR-9-Mediated SIRT1/NF-κB Signaling Pathway
Dihydromyricetin (DMY), a natural flavonoid compound extracted from the stems and leaves of Ampelopsis grossedentata, has been found as a potential therapeutic chemical for treating atherosclerosis. This study explores the underlying mechanism of DMY repressing M1 macrophage polarization in atherosc...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2023/2547588 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832547904133267456 |
|---|---|
| author | Zhousheng Yang Tianyu Li Chunyan Wang Mingyu Meng Shenglan Tan Lei Chen |
| author_facet | Zhousheng Yang Tianyu Li Chunyan Wang Mingyu Meng Shenglan Tan Lei Chen |
| author_sort | Zhousheng Yang |
| collection | DOAJ |
| description | Dihydromyricetin (DMY), a natural flavonoid compound extracted from the stems and leaves of Ampelopsis grossedentata, has been found as a potential therapeutic chemical for treating atherosclerosis. This study explores the underlying mechanism of DMY repressing M1 macrophage polarization in atherosclerosis. We showed that DMY treatment markedly decreased M1 macrophage markers (e.g., Tnf-α and IL-1β) and p65-positive macrophage numbers in the vessel wall of Apoe-deficient (Apoe–/–) mice. Overexpression of miR-9 or knockdown of SIRT1 in macrophages reversed the effect of DMY on M1 macrophage polarization. The data we presented in the study indicate that the miR-9-mediated SIRT1/NF-κB pathway plays a pivotal role in M1 macrophage polarization and is one of the molecular mechanisms underlying the anti-atherosclerosis effects of DMY. We provide new solid evidence that DMY may be explored as a potential therapeutic adjuvant for treating atherosclerosis. |
| format | Article |
| id | doaj-art-29382f3689fd4066a3eb2441f4778fe3 |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-29382f3689fd4066a3eb2441f4778fe32025-02-03T06:42:47ZengWileyMediators of Inflammation1466-18612023-01-01202310.1155/2023/2547588Dihydromyricetin Inhibits M1 Macrophage Polarization in Atherosclerosis by Modulating miR-9-Mediated SIRT1/NF-κB Signaling PathwayZhousheng Yang0Tianyu Li1Chunyan Wang2Mingyu Meng3Shenglan Tan4Lei Chen5Department of PharmacyDepartment of PharmacyDepartment of PharmacyDepartment of PharmacyDepartment of PharmacyDepartment of PharmacyDihydromyricetin (DMY), a natural flavonoid compound extracted from the stems and leaves of Ampelopsis grossedentata, has been found as a potential therapeutic chemical for treating atherosclerosis. This study explores the underlying mechanism of DMY repressing M1 macrophage polarization in atherosclerosis. We showed that DMY treatment markedly decreased M1 macrophage markers (e.g., Tnf-α and IL-1β) and p65-positive macrophage numbers in the vessel wall of Apoe-deficient (Apoe–/–) mice. Overexpression of miR-9 or knockdown of SIRT1 in macrophages reversed the effect of DMY on M1 macrophage polarization. The data we presented in the study indicate that the miR-9-mediated SIRT1/NF-κB pathway plays a pivotal role in M1 macrophage polarization and is one of the molecular mechanisms underlying the anti-atherosclerosis effects of DMY. We provide new solid evidence that DMY may be explored as a potential therapeutic adjuvant for treating atherosclerosis.http://dx.doi.org/10.1155/2023/2547588 |
| spellingShingle | Zhousheng Yang Tianyu Li Chunyan Wang Mingyu Meng Shenglan Tan Lei Chen Dihydromyricetin Inhibits M1 Macrophage Polarization in Atherosclerosis by Modulating miR-9-Mediated SIRT1/NF-κB Signaling Pathway Mediators of Inflammation |
| title | Dihydromyricetin Inhibits M1 Macrophage Polarization in Atherosclerosis by Modulating miR-9-Mediated SIRT1/NF-κB Signaling Pathway |
| title_full | Dihydromyricetin Inhibits M1 Macrophage Polarization in Atherosclerosis by Modulating miR-9-Mediated SIRT1/NF-κB Signaling Pathway |
| title_fullStr | Dihydromyricetin Inhibits M1 Macrophage Polarization in Atherosclerosis by Modulating miR-9-Mediated SIRT1/NF-κB Signaling Pathway |
| title_full_unstemmed | Dihydromyricetin Inhibits M1 Macrophage Polarization in Atherosclerosis by Modulating miR-9-Mediated SIRT1/NF-κB Signaling Pathway |
| title_short | Dihydromyricetin Inhibits M1 Macrophage Polarization in Atherosclerosis by Modulating miR-9-Mediated SIRT1/NF-κB Signaling Pathway |
| title_sort | dihydromyricetin inhibits m1 macrophage polarization in atherosclerosis by modulating mir 9 mediated sirt1 nf κb signaling pathway |
| url | http://dx.doi.org/10.1155/2023/2547588 |
| work_keys_str_mv | AT zhoushengyang dihydromyricetininhibitsm1macrophagepolarizationinatherosclerosisbymodulatingmir9mediatedsirt1nfkbsignalingpathway AT tianyuli dihydromyricetininhibitsm1macrophagepolarizationinatherosclerosisbymodulatingmir9mediatedsirt1nfkbsignalingpathway AT chunyanwang dihydromyricetininhibitsm1macrophagepolarizationinatherosclerosisbymodulatingmir9mediatedsirt1nfkbsignalingpathway AT mingyumeng dihydromyricetininhibitsm1macrophagepolarizationinatherosclerosisbymodulatingmir9mediatedsirt1nfkbsignalingpathway AT shenglantan dihydromyricetininhibitsm1macrophagepolarizationinatherosclerosisbymodulatingmir9mediatedsirt1nfkbsignalingpathway AT leichen dihydromyricetininhibitsm1macrophagepolarizationinatherosclerosisbymodulatingmir9mediatedsirt1nfkbsignalingpathway |