Clinical Features of Four West Nile Virus Cases and Its Molecular Characterization from a South Indian Tertiary Care Hospital
West Nile virus (WNV) is currently a significant reemerging virus of the 21st century. It belongs to the family Flaviviridae and genus Flavivirus. Although it is primarily transmitted by the Culex spp of mosquitoes, other routes of transmission are also well defined. Of eight lineages described, Lin...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2020/1315041 |
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| author | Shoba Mammen Aiswarya Nair Santhosh Kumar Zayina Zonderveni A. T. Prabhakar Turaka Vijay Prakash Sanjith Aaron Mathew Alexander Anand Zachariah Asha Mary Abraham |
| author_facet | Shoba Mammen Aiswarya Nair Santhosh Kumar Zayina Zonderveni A. T. Prabhakar Turaka Vijay Prakash Sanjith Aaron Mathew Alexander Anand Zachariah Asha Mary Abraham |
| author_sort | Shoba Mammen |
| collection | DOAJ |
| description | West Nile virus (WNV) is currently a significant reemerging virus of the 21st century. It belongs to the family Flaviviridae and genus Flavivirus. Although it is primarily transmitted by the Culex spp of mosquitoes, other routes of transmission are also well defined. Of eight lineages described, Lineage 1a has been reported from many parts of South India and is known to cause neuroinvasive illness. Many tests and serological techniques have been described to diagnose WNV infection such as complement fixation, neutralization, heamagglutination inhibition, ELISA, and PCR for molecular confirmation. The latter far outweighs the limitations inherent in the other tests. WNV infection is being reported from Vellore for the first time after 1968. This paper aims to describe four cases of WNV infection causing central nervous system manifestations with its molecular characterization. West Nile virus infection was diagnosed with the available molecular techniques such as PCR and sequencing, which emphasizes the need for considering West Nile virus in the differential diagnosis of acute meningoencephalitis and the wider availability of molecular diagnostic tests. |
| format | Article |
| id | doaj-art-29305b8ae4534a5ea91b84a2cb476650 |
| institution | Kabale University |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-29305b8ae4534a5ea91b84a2cb4766502025-02-03T01:03:50ZengWileyCase Reports in Infectious Diseases2090-66252090-66332020-01-01202010.1155/2020/13150411315041Clinical Features of Four West Nile Virus Cases and Its Molecular Characterization from a South Indian Tertiary Care HospitalShoba Mammen0Aiswarya Nair1Santhosh Kumar2Zayina Zonderveni3A. T. Prabhakar4Turaka Vijay Prakash5Sanjith Aaron6Mathew Alexander7Anand Zachariah8Asha Mary Abraham9Department of Clinical Virology, Christian Medical College, Vellore, Tamil Nadu, IndiaDepartment of Medicine, Christian Medical College, Vellore, Tamil Nadu, IndiaDepartment of Clinical Virology, Christian Medical College, Vellore, Tamil Nadu, IndiaDepartment of Clinical Virology, Christian Medical College, Vellore, Tamil Nadu, IndiaDepartment of Neurology, Christian Medical College, Vellore, Tamil Nadu, IndiaDepartment of Medicine, Christian Medical College, Vellore, Tamil Nadu, IndiaDepartment of Neurology, Christian Medical College, Vellore, Tamil Nadu, IndiaDepartment of Neurology, Christian Medical College, Vellore, Tamil Nadu, IndiaDepartment of Medicine, Christian Medical College, Vellore, Tamil Nadu, IndiaDepartment of Clinical Virology, Christian Medical College, Vellore, Tamil Nadu, IndiaWest Nile virus (WNV) is currently a significant reemerging virus of the 21st century. It belongs to the family Flaviviridae and genus Flavivirus. Although it is primarily transmitted by the Culex spp of mosquitoes, other routes of transmission are also well defined. Of eight lineages described, Lineage 1a has been reported from many parts of South India and is known to cause neuroinvasive illness. Many tests and serological techniques have been described to diagnose WNV infection such as complement fixation, neutralization, heamagglutination inhibition, ELISA, and PCR for molecular confirmation. The latter far outweighs the limitations inherent in the other tests. WNV infection is being reported from Vellore for the first time after 1968. This paper aims to describe four cases of WNV infection causing central nervous system manifestations with its molecular characterization. West Nile virus infection was diagnosed with the available molecular techniques such as PCR and sequencing, which emphasizes the need for considering West Nile virus in the differential diagnosis of acute meningoencephalitis and the wider availability of molecular diagnostic tests.http://dx.doi.org/10.1155/2020/1315041 |
| spellingShingle | Shoba Mammen Aiswarya Nair Santhosh Kumar Zayina Zonderveni A. T. Prabhakar Turaka Vijay Prakash Sanjith Aaron Mathew Alexander Anand Zachariah Asha Mary Abraham Clinical Features of Four West Nile Virus Cases and Its Molecular Characterization from a South Indian Tertiary Care Hospital Case Reports in Infectious Diseases |
| title | Clinical Features of Four West Nile Virus Cases and Its Molecular Characterization from a South Indian Tertiary Care Hospital |
| title_full | Clinical Features of Four West Nile Virus Cases and Its Molecular Characterization from a South Indian Tertiary Care Hospital |
| title_fullStr | Clinical Features of Four West Nile Virus Cases and Its Molecular Characterization from a South Indian Tertiary Care Hospital |
| title_full_unstemmed | Clinical Features of Four West Nile Virus Cases and Its Molecular Characterization from a South Indian Tertiary Care Hospital |
| title_short | Clinical Features of Four West Nile Virus Cases and Its Molecular Characterization from a South Indian Tertiary Care Hospital |
| title_sort | clinical features of four west nile virus cases and its molecular characterization from a south indian tertiary care hospital |
| url | http://dx.doi.org/10.1155/2020/1315041 |
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