Peripheral T Cell Non-Hodgkin’s Lymphoma following Treatment of Hodgkin’s Lymphoma
Previous reports have suggested that non-Hodgkin’s lymphoma (NHL) is more likely to develop in patients with Hodgkin lymphoma (HL) compared to the general population. These two can occur synchronously or metachronously. We report here on a case of nodular sclerosis classical HL and T cell NHL that o...
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Wiley
2015-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2015/438385 |
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| author | Sun Hee Chang Hye Ran Lee |
| author_facet | Sun Hee Chang Hye Ran Lee |
| author_sort | Sun Hee Chang |
| collection | DOAJ |
| description | Previous reports have suggested that non-Hodgkin’s lymphoma (NHL) is more likely to develop in patients with Hodgkin lymphoma (HL) compared to the general population. These two can occur synchronously or metachronously. We report here on a case of nodular sclerosis classical HL and T cell NHL that occurred in a patient metachronously. Peripheral T cell lymphoma (PTCL) of the patient was found about 2 years after treatment of classical HL. When the patient was diagnosed with HL, biopsy revealed typical RS cells, presenting positive for CD30 and CD15 and negative for CD79a and CD3 in immunohistochemistry. And PCR analysis showed IgH gene rearrangement; however, T cell receptor gene rearrangement and Epstein-Barr virus (EBV) were not detected on PCR analysis. After 2 years of treatment of HL, colonoscopic biopsy and lymph node biopsy showed CD3 positive atypical cells intermixed with small reactive lymphoid cells and plasma cells, indicating T cell lymphoma. PCR analysis demonstrated T cell receptor gene rearrangement and did not detect EBV. Although it is rare, synchronous or metachronous HL and NHL may occur. Therefore, we may need to ensure pathological confirmation, especially in case of lymphoma that did not respond to chemotherapy. |
| format | Article |
| id | doaj-art-292f1bc65e5d4e7c8fa62328f7d52289 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
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| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-292f1bc65e5d4e7c8fa62328f7d522892025-02-03T05:54:20ZengWileyCase Reports in Oncological Medicine2090-67062090-67142015-01-01201510.1155/2015/438385438385Peripheral T Cell Non-Hodgkin’s Lymphoma following Treatment of Hodgkin’s LymphomaSun Hee Chang0Hye Ran Lee1Department of Pathology, Inje University Ilsan Paik Hospital, 170 Joohwa-ro, Ilsanseo-gu, Goyang 411-706, Republic of KoreaDepartment of Internal Medicine, Inje University Ilsan Paik Hospital, 170 Joohwa-ro, Ilsanseo-gu, Goyang 411-706, Republic of KoreaPrevious reports have suggested that non-Hodgkin’s lymphoma (NHL) is more likely to develop in patients with Hodgkin lymphoma (HL) compared to the general population. These two can occur synchronously or metachronously. We report here on a case of nodular sclerosis classical HL and T cell NHL that occurred in a patient metachronously. Peripheral T cell lymphoma (PTCL) of the patient was found about 2 years after treatment of classical HL. When the patient was diagnosed with HL, biopsy revealed typical RS cells, presenting positive for CD30 and CD15 and negative for CD79a and CD3 in immunohistochemistry. And PCR analysis showed IgH gene rearrangement; however, T cell receptor gene rearrangement and Epstein-Barr virus (EBV) were not detected on PCR analysis. After 2 years of treatment of HL, colonoscopic biopsy and lymph node biopsy showed CD3 positive atypical cells intermixed with small reactive lymphoid cells and plasma cells, indicating T cell lymphoma. PCR analysis demonstrated T cell receptor gene rearrangement and did not detect EBV. Although it is rare, synchronous or metachronous HL and NHL may occur. Therefore, we may need to ensure pathological confirmation, especially in case of lymphoma that did not respond to chemotherapy.http://dx.doi.org/10.1155/2015/438385 |
| spellingShingle | Sun Hee Chang Hye Ran Lee Peripheral T Cell Non-Hodgkin’s Lymphoma following Treatment of Hodgkin’s Lymphoma Case Reports in Oncological Medicine |
| title | Peripheral T Cell Non-Hodgkin’s Lymphoma following Treatment of Hodgkin’s Lymphoma |
| title_full | Peripheral T Cell Non-Hodgkin’s Lymphoma following Treatment of Hodgkin’s Lymphoma |
| title_fullStr | Peripheral T Cell Non-Hodgkin’s Lymphoma following Treatment of Hodgkin’s Lymphoma |
| title_full_unstemmed | Peripheral T Cell Non-Hodgkin’s Lymphoma following Treatment of Hodgkin’s Lymphoma |
| title_short | Peripheral T Cell Non-Hodgkin’s Lymphoma following Treatment of Hodgkin’s Lymphoma |
| title_sort | peripheral t cell non hodgkin s lymphoma following treatment of hodgkin s lymphoma |
| url | http://dx.doi.org/10.1155/2015/438385 |
| work_keys_str_mv | AT sunheechang peripheraltcellnonhodgkinslymphomafollowingtreatmentofhodgkinslymphoma AT hyeranlee peripheraltcellnonhodgkinslymphomafollowingtreatmentofhodgkinslymphoma |