Laser interstitial thermal therapy in the management of bottom‐of‐sulcus dysplasia‐related epilepsy
Abstract Objective This study assessed the efficacy and safety of magnetic resonance‐guided laser interstitial thermal therapy (MRgLITT) versus open surgery (OS) for the treatment of patients with bottom‐of‐sulcus dysplasia (BOSD)‐related epilepsy. Methods Twenty‐two patients underwent MRgLITT, whil...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
|
| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.52258 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832592628927954944 |
|---|---|
| author | Bowen Yang Chao Zhang Xiu Wang Baotian Zhao Jiajie Mo Weiyuan Luo Xiaoqiu Shao Jianguo Zhang Kai Zhang Wenhan Hu |
| author_facet | Bowen Yang Chao Zhang Xiu Wang Baotian Zhao Jiajie Mo Weiyuan Luo Xiaoqiu Shao Jianguo Zhang Kai Zhang Wenhan Hu |
| author_sort | Bowen Yang |
| collection | DOAJ |
| description | Abstract Objective This study assessed the efficacy and safety of magnetic resonance‐guided laser interstitial thermal therapy (MRgLITT) versus open surgery (OS) for the treatment of patients with bottom‐of‐sulcus dysplasia (BOSD)‐related epilepsy. Methods Twenty‐two patients underwent MRgLITT, while 39 underwent OS. Postoperative seizure‐free rates were analyzed using Kaplan–Meier curves. The removal ratio, which represents the extent of damage, was calculated based on preoperative lesion volume and postoperative removal volume. Other outcomes, including adverse events, operative time, and hospital stay, were also compared. Results Kaplan–Meier curves indicated the seizure‐free rates were comparable between the MRgLITT group (90.9%, 26.5 [23.0, 35.1] months) and OS group (89.7%, 25.2 [16.2, 34.6] months) at the final follow‐up (p = 0.901, log‐rank test). The removal ratio of MRgLITT (1.3 [1.1, 1.7]) was significantly lower (p = 0.007) than that of OS (5.8 [3.6, 8.5]). A comparison of postoperative neurological deficits, infection rates, and fever rates revealed no significant differences between MRgLITT and OS groups. The operative time (hours) of MRgLITT (3.0, [2.1, 4.9]) was significantly shorter (p = 0.007) than that of OS (3.5 [3.0, 4.5]). The hospital stay (days) after MRgLITT (6 [5.0, 7.5]) was significantly shorter (p < 0.001) than that of OS (11.0 [9.0, 13.5]). Interpretation MRgLITT has advantages over OS, including comparable seizure control and adverse event profiles, along with reduced removal ratios, shorter operative time, and shorter hospital stays. |
| format | Article |
| id | doaj-art-292bc5c8517240538dc96b4eef8b2970 |
| institution | Kabale University |
| issn | 2328-9503 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj-art-292bc5c8517240538dc96b4eef8b29702025-01-21T05:41:42ZengWileyAnnals of Clinical and Translational Neurology2328-95032025-01-0112111012010.1002/acn3.52258Laser interstitial thermal therapy in the management of bottom‐of‐sulcus dysplasia‐related epilepsyBowen Yang0Chao Zhang1Xiu Wang2Baotian Zhao3Jiajie Mo4Weiyuan Luo5Xiaoqiu Shao6Jianguo Zhang7Kai Zhang8Wenhan Hu9Department of Neurosurgery, Beijing Tiantan Hospital Capital Medical University Beijing ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital Capital Medical University Beijing ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital Capital Medical University Beijing ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital Capital Medical University Beijing ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital Capital Medical University Beijing ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital Capital Medical University Beijing ChinaDepartment of Neurology, Beijing Tiantan Hospital Capital Medical University Beijing ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital Capital Medical University Beijing ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital Capital Medical University Beijing ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital Capital Medical University Beijing ChinaAbstract Objective This study assessed the efficacy and safety of magnetic resonance‐guided laser interstitial thermal therapy (MRgLITT) versus open surgery (OS) for the treatment of patients with bottom‐of‐sulcus dysplasia (BOSD)‐related epilepsy. Methods Twenty‐two patients underwent MRgLITT, while 39 underwent OS. Postoperative seizure‐free rates were analyzed using Kaplan–Meier curves. The removal ratio, which represents the extent of damage, was calculated based on preoperative lesion volume and postoperative removal volume. Other outcomes, including adverse events, operative time, and hospital stay, were also compared. Results Kaplan–Meier curves indicated the seizure‐free rates were comparable between the MRgLITT group (90.9%, 26.5 [23.0, 35.1] months) and OS group (89.7%, 25.2 [16.2, 34.6] months) at the final follow‐up (p = 0.901, log‐rank test). The removal ratio of MRgLITT (1.3 [1.1, 1.7]) was significantly lower (p = 0.007) than that of OS (5.8 [3.6, 8.5]). A comparison of postoperative neurological deficits, infection rates, and fever rates revealed no significant differences between MRgLITT and OS groups. The operative time (hours) of MRgLITT (3.0, [2.1, 4.9]) was significantly shorter (p = 0.007) than that of OS (3.5 [3.0, 4.5]). The hospital stay (days) after MRgLITT (6 [5.0, 7.5]) was significantly shorter (p < 0.001) than that of OS (11.0 [9.0, 13.5]). Interpretation MRgLITT has advantages over OS, including comparable seizure control and adverse event profiles, along with reduced removal ratios, shorter operative time, and shorter hospital stays.https://doi.org/10.1002/acn3.52258 |
| spellingShingle | Bowen Yang Chao Zhang Xiu Wang Baotian Zhao Jiajie Mo Weiyuan Luo Xiaoqiu Shao Jianguo Zhang Kai Zhang Wenhan Hu Laser interstitial thermal therapy in the management of bottom‐of‐sulcus dysplasia‐related epilepsy Annals of Clinical and Translational Neurology |
| title | Laser interstitial thermal therapy in the management of bottom‐of‐sulcus dysplasia‐related epilepsy |
| title_full | Laser interstitial thermal therapy in the management of bottom‐of‐sulcus dysplasia‐related epilepsy |
| title_fullStr | Laser interstitial thermal therapy in the management of bottom‐of‐sulcus dysplasia‐related epilepsy |
| title_full_unstemmed | Laser interstitial thermal therapy in the management of bottom‐of‐sulcus dysplasia‐related epilepsy |
| title_short | Laser interstitial thermal therapy in the management of bottom‐of‐sulcus dysplasia‐related epilepsy |
| title_sort | laser interstitial thermal therapy in the management of bottom of sulcus dysplasia related epilepsy |
| url | https://doi.org/10.1002/acn3.52258 |
| work_keys_str_mv | AT bowenyang laserinterstitialthermaltherapyinthemanagementofbottomofsulcusdysplasiarelatedepilepsy AT chaozhang laserinterstitialthermaltherapyinthemanagementofbottomofsulcusdysplasiarelatedepilepsy AT xiuwang laserinterstitialthermaltherapyinthemanagementofbottomofsulcusdysplasiarelatedepilepsy AT baotianzhao laserinterstitialthermaltherapyinthemanagementofbottomofsulcusdysplasiarelatedepilepsy AT jiajiemo laserinterstitialthermaltherapyinthemanagementofbottomofsulcusdysplasiarelatedepilepsy AT weiyuanluo laserinterstitialthermaltherapyinthemanagementofbottomofsulcusdysplasiarelatedepilepsy AT xiaoqiushao laserinterstitialthermaltherapyinthemanagementofbottomofsulcusdysplasiarelatedepilepsy AT jianguozhang laserinterstitialthermaltherapyinthemanagementofbottomofsulcusdysplasiarelatedepilepsy AT kaizhang laserinterstitialthermaltherapyinthemanagementofbottomofsulcusdysplasiarelatedepilepsy AT wenhanhu laserinterstitialthermaltherapyinthemanagementofbottomofsulcusdysplasiarelatedepilepsy |