Association between Visual Acuity and Retinal Layer Metrics in Diabetics with and without Macular Edema
Purpose. Diabetes is known to cause alterations in retinal microvasculature and tissue that progressively lead to visual impairment. Optical coherence tomography (OCT) is useful for assessment of total retinal thickening due to diabetic macular edema (DME). In the current study, we determined associ...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2018/1089043 |
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| author | LakshmiPriya Rangaraju Xuejuan Jiang J. Jason McAnany Michael R. Tan Justin Wanek Norman P. Blair Jennifer I. Lim Mahnaz Shahidi |
| author_facet | LakshmiPriya Rangaraju Xuejuan Jiang J. Jason McAnany Michael R. Tan Justin Wanek Norman P. Blair Jennifer I. Lim Mahnaz Shahidi |
| author_sort | LakshmiPriya Rangaraju |
| collection | DOAJ |
| description | Purpose. Diabetes is known to cause alterations in retinal microvasculature and tissue that progressively lead to visual impairment. Optical coherence tomography (OCT) is useful for assessment of total retinal thickening due to diabetic macular edema (DME). In the current study, we determined associations between visual acuity (VA) and retinal layer thickness, reflectance, and interface disruption derived from enface OCT images in subjects with and without DME. Materials and Methods. Best corrected VA was measured and high-density OCT volume scans were acquired in 149 diabetic subjects. A previously established image segmentation method identified retinal layer interfaces and locations of visually indiscernible (disrupted) interfaces. Enface thickness maps and reflectance images of the nerve fiber layer (NFL), combined ganglion cell and inner plexiform layer (GCLIPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), photoreceptor outer segment layer (OSL), and retinal pigment epithelium (RPE) were generated in the central macular subfield. The associations among VA and retinal layer metrics were determined by multivariate linear regressions after adjusting for covariates (age, sex, race, HbA1c, diabetes type, and duration) and correcting for multiple comparisons. Results. In DME subjects, increased GCLIPL and OPL thickness and decreased OSL thickness were associated with reduced VA. Furthermore, increased NFL reflectance and decreased OSL reflectance were associated with reduced VA. Additionally, increased areas of INL and ONL interface disruptions were associated with reduced VA. In subjects without DME, increased INL thickness was associated with reduced VA, whereas in subjects without DME but with previous antivascular endothelium growth factor treatment, thickening of OPL was associated with reduced VA. Conclusions. Alterations in retinal layer thickness and reflectance metrics derived from enface OCT images were associated with reduced VA with and without presence of DME, suggestive of their potential for monitoring development, progression, and treatment of DME. |
| format | Article |
| id | doaj-art-291bde03123148e9814486c5130df86c |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-291bde03123148e9814486c5130df86c2025-02-03T01:21:56ZengWileyJournal of Ophthalmology2090-004X2090-00582018-01-01201810.1155/2018/10890431089043Association between Visual Acuity and Retinal Layer Metrics in Diabetics with and without Macular EdemaLakshmiPriya Rangaraju0Xuejuan Jiang1J. Jason McAnany2Michael R. Tan3Justin Wanek4Norman P. Blair5Jennifer I. Lim6Mahnaz Shahidi7Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USADepartment of Ophthalmology, University of Southern California, Los Angeles, CA, USADepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USADepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USADepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USADepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USADepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USADepartment of Ophthalmology, University of Southern California, Los Angeles, CA, USAPurpose. Diabetes is known to cause alterations in retinal microvasculature and tissue that progressively lead to visual impairment. Optical coherence tomography (OCT) is useful for assessment of total retinal thickening due to diabetic macular edema (DME). In the current study, we determined associations between visual acuity (VA) and retinal layer thickness, reflectance, and interface disruption derived from enface OCT images in subjects with and without DME. Materials and Methods. Best corrected VA was measured and high-density OCT volume scans were acquired in 149 diabetic subjects. A previously established image segmentation method identified retinal layer interfaces and locations of visually indiscernible (disrupted) interfaces. Enface thickness maps and reflectance images of the nerve fiber layer (NFL), combined ganglion cell and inner plexiform layer (GCLIPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), photoreceptor outer segment layer (OSL), and retinal pigment epithelium (RPE) were generated in the central macular subfield. The associations among VA and retinal layer metrics were determined by multivariate linear regressions after adjusting for covariates (age, sex, race, HbA1c, diabetes type, and duration) and correcting for multiple comparisons. Results. In DME subjects, increased GCLIPL and OPL thickness and decreased OSL thickness were associated with reduced VA. Furthermore, increased NFL reflectance and decreased OSL reflectance were associated with reduced VA. Additionally, increased areas of INL and ONL interface disruptions were associated with reduced VA. In subjects without DME, increased INL thickness was associated with reduced VA, whereas in subjects without DME but with previous antivascular endothelium growth factor treatment, thickening of OPL was associated with reduced VA. Conclusions. Alterations in retinal layer thickness and reflectance metrics derived from enface OCT images were associated with reduced VA with and without presence of DME, suggestive of their potential for monitoring development, progression, and treatment of DME.http://dx.doi.org/10.1155/2018/1089043 |
| spellingShingle | LakshmiPriya Rangaraju Xuejuan Jiang J. Jason McAnany Michael R. Tan Justin Wanek Norman P. Blair Jennifer I. Lim Mahnaz Shahidi Association between Visual Acuity and Retinal Layer Metrics in Diabetics with and without Macular Edema Journal of Ophthalmology |
| title | Association between Visual Acuity and Retinal Layer Metrics in Diabetics with and without Macular Edema |
| title_full | Association between Visual Acuity and Retinal Layer Metrics in Diabetics with and without Macular Edema |
| title_fullStr | Association between Visual Acuity and Retinal Layer Metrics in Diabetics with and without Macular Edema |
| title_full_unstemmed | Association between Visual Acuity and Retinal Layer Metrics in Diabetics with and without Macular Edema |
| title_short | Association between Visual Acuity and Retinal Layer Metrics in Diabetics with and without Macular Edema |
| title_sort | association between visual acuity and retinal layer metrics in diabetics with and without macular edema |
| url | http://dx.doi.org/10.1155/2018/1089043 |
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