Synthesis of [l-Nal3] thymopoietin II and examination of its immunological effect on the uremic T-lymphocytes
A TP II analogue, [l-Nal3] TP II, was synthesized by a conventional solution method, followed by deprotection with 1M TFMSA-thioanisole (molar ratio 1:1) in TFA in the presence of Me2Se and m-cresol as scavengers. The synthetic [l-Nal3] TP II, TP II and [Phe (4 F)3] TP II were tested for comparative...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2000-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1080/09629350020002930 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564179223969792 |
|---|---|
| author | T. Abiko S. Nakatsubo |
| author_facet | T. Abiko S. Nakatsubo |
| author_sort | T. Abiko |
| collection | DOAJ |
| description | A TP II analogue, [l-Nal3] TP II, was synthesized by a conventional solution method, followed by deprotection with 1M TFMSA-thioanisole (molar ratio 1:1) in TFA in the presence of Me2Se and m-cresol as scavengers. The synthetic [l-Nal3] TP II, TP II and [Phe (4 F)3] TP II were tested for comparative effect on the impaired T-lymphocyte transformation by PHA in uremic patients suffering from recurrent infectious diseases. The synthetic analogue was found to have stronger restorative activity than those of our synthetic TP II and [Phe
(4 F)3] TP II. |
| format | Article |
| id | doaj-art-2911084bc49a4c51b361e9b2b4b0a895 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2000-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-2911084bc49a4c51b361e9b2b4b0a8952025-02-03T01:11:32ZengWileyMediators of Inflammation0962-93511466-18612000-01-0193-420120610.1080/09629350020002930Synthesis of [l-Nal3] thymopoietin II and examination of its immunological effect on the uremic T-lymphocytesT. Abiko0S. Nakatsubo1Research Laboratory, Global Shinwa Pharmaceutical Co. Ltd, 2–546–1, Yoriki, Matsuomura, Iwate-gun, Iwate-ken, 028–7302, JapanResearch Laboratory, Global Shinwa Pharmaceutical Co. Ltd, 2–546–1, Yoriki, Matsuomura, Iwate-gun, Iwate-ken, 028–7302, JapanA TP II analogue, [l-Nal3] TP II, was synthesized by a conventional solution method, followed by deprotection with 1M TFMSA-thioanisole (molar ratio 1:1) in TFA in the presence of Me2Se and m-cresol as scavengers. The synthetic [l-Nal3] TP II, TP II and [Phe (4 F)3] TP II were tested for comparative effect on the impaired T-lymphocyte transformation by PHA in uremic patients suffering from recurrent infectious diseases. The synthetic analogue was found to have stronger restorative activity than those of our synthetic TP II and [Phe (4 F)3] TP II.http://dx.doi.org/10.1080/09629350020002930 |
| spellingShingle | T. Abiko S. Nakatsubo Synthesis of [l-Nal3] thymopoietin II and examination of its immunological effect on the uremic T-lymphocytes Mediators of Inflammation |
| title | Synthesis of [l-Nal3] thymopoietin II and examination of its immunological effect on the uremic T-lymphocytes |
| title_full | Synthesis of [l-Nal3] thymopoietin II and examination of its immunological effect on the uremic T-lymphocytes |
| title_fullStr | Synthesis of [l-Nal3] thymopoietin II and examination of its immunological effect on the uremic T-lymphocytes |
| title_full_unstemmed | Synthesis of [l-Nal3] thymopoietin II and examination of its immunological effect on the uremic T-lymphocytes |
| title_short | Synthesis of [l-Nal3] thymopoietin II and examination of its immunological effect on the uremic T-lymphocytes |
| title_sort | synthesis of l nal3 thymopoietin ii and examination of its immunological effect on the uremic t lymphocytes |
| url | http://dx.doi.org/10.1080/09629350020002930 |
| work_keys_str_mv | AT tabiko synthesisoflnal3thymopoietiniiandexaminationofitsimmunologicaleffectontheuremictlymphocytes AT snakatsubo synthesisoflnal3thymopoietiniiandexaminationofitsimmunologicaleffectontheuremictlymphocytes |