Functional Near-Infrared Spectroscopy to Probe State- and Trait-Like Conditions in Chronic Tinnitus: A Proof-of-Principle Study
Objective. Several neuroscience tools showed the involvement of auditory cortex in chronic tinnitus. In this proof-of-principle study we probed the capability of functional near-infrared spectroscopy (fNIRS) for the measurement of brain oxygenation in auditory cortex in dependence from chronic tinni...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2014/894203 |
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| author | Martin Schecklmann Anette Giani Sara Tupak Berthold Langguth Vincent Raab Thomas Polak Csanád Várallyay Wilma Harnisch Martin J. Herrmann Andreas J. Fallgatter |
| author_facet | Martin Schecklmann Anette Giani Sara Tupak Berthold Langguth Vincent Raab Thomas Polak Csanád Várallyay Wilma Harnisch Martin J. Herrmann Andreas J. Fallgatter |
| author_sort | Martin Schecklmann |
| collection | DOAJ |
| description | Objective. Several neuroscience tools showed the involvement of auditory cortex in chronic tinnitus. In this proof-of-principle study we probed the capability of functional near-infrared spectroscopy (fNIRS) for the measurement of brain oxygenation in auditory cortex in dependence from chronic tinnitus and from intervention with transcranial magnetic stimulation. Methods. Twenty-three patients received continuous theta burst stimulation over the left primary auditory cortex in a randomized sham-controlled neuronavigated trial (verum = 12; placebo = 11). Before and after treatment, sound-evoked brain oxygenation in temporal areas was measured with fNIRS. Brain oxygenation was measured once in healthy controls (n=12). Results. Sound-evoked activity in right temporal areas was increased in the patients in contrast to healthy controls. Left-sided temporal activity under the stimulated area changed over the course of the trial; high baseline oxygenation was reduced and vice versa. Conclusions. By demonstrating that rTMS interacts with auditory evoked brain activity, our results confirm earlier electrophysiological findings and indicate the sensitivity of fNIRS for detecting rTMS induced changes in brain activity. Moreover, our findings of trait- and state-related oxygenation changes indicate the potential of fNIRS for the investigation of tinnitus pathophysiology and treatment response. |
| format | Article |
| id | doaj-art-290b3356eb1e4856b62b86412d18df8e |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-290b3356eb1e4856b62b86412d18df8e2025-02-03T06:11:42ZengWileyNeural Plasticity2090-59041687-54432014-01-01201410.1155/2014/894203894203Functional Near-Infrared Spectroscopy to Probe State- and Trait-Like Conditions in Chronic Tinnitus: A Proof-of-Principle StudyMartin Schecklmann0Anette Giani1Sara Tupak2Berthold Langguth3Vincent Raab4Thomas Polak5Csanád Várallyay6Wilma Harnisch7Martin J. Herrmann8Andreas J. Fallgatter9Department of Psychiatry and Psychotherapy, University of Regensburg, Universitätsstraße 84, 93053 Regensburg, GermanyMax Planck Institute for Biological Cybernetics, 72076 Tübingen, GermanyInstitute of Medical Psychology and Systems Neuroscience, University of Münster, 48149 Münster, GermanyDepartment of Psychiatry and Psychotherapy, University of Regensburg, Universitätsstraße 84, 93053 Regensburg, GermanyDepartment of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, 97080 Würzburg, GermanyDepartment of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, 97080 Würzburg, GermanyDepartment of Neurosurgery, University of Würzburg, 97080 Würzburg, GermanyDepartment of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University of Würzburg, 97080 Würzburg, GermanyDepartment of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, 97080 Würzburg, GermanyDepartment of Psychiatry and Psychotherapy, University of Tübingen, 72076 Tübingen, GermanyObjective. Several neuroscience tools showed the involvement of auditory cortex in chronic tinnitus. In this proof-of-principle study we probed the capability of functional near-infrared spectroscopy (fNIRS) for the measurement of brain oxygenation in auditory cortex in dependence from chronic tinnitus and from intervention with transcranial magnetic stimulation. Methods. Twenty-three patients received continuous theta burst stimulation over the left primary auditory cortex in a randomized sham-controlled neuronavigated trial (verum = 12; placebo = 11). Before and after treatment, sound-evoked brain oxygenation in temporal areas was measured with fNIRS. Brain oxygenation was measured once in healthy controls (n=12). Results. Sound-evoked activity in right temporal areas was increased in the patients in contrast to healthy controls. Left-sided temporal activity under the stimulated area changed over the course of the trial; high baseline oxygenation was reduced and vice versa. Conclusions. By demonstrating that rTMS interacts with auditory evoked brain activity, our results confirm earlier electrophysiological findings and indicate the sensitivity of fNIRS for detecting rTMS induced changes in brain activity. Moreover, our findings of trait- and state-related oxygenation changes indicate the potential of fNIRS for the investigation of tinnitus pathophysiology and treatment response.http://dx.doi.org/10.1155/2014/894203 |
| spellingShingle | Martin Schecklmann Anette Giani Sara Tupak Berthold Langguth Vincent Raab Thomas Polak Csanád Várallyay Wilma Harnisch Martin J. Herrmann Andreas J. Fallgatter Functional Near-Infrared Spectroscopy to Probe State- and Trait-Like Conditions in Chronic Tinnitus: A Proof-of-Principle Study Neural Plasticity |
| title | Functional Near-Infrared Spectroscopy to Probe State- and Trait-Like Conditions in Chronic Tinnitus: A Proof-of-Principle Study |
| title_full | Functional Near-Infrared Spectroscopy to Probe State- and Trait-Like Conditions in Chronic Tinnitus: A Proof-of-Principle Study |
| title_fullStr | Functional Near-Infrared Spectroscopy to Probe State- and Trait-Like Conditions in Chronic Tinnitus: A Proof-of-Principle Study |
| title_full_unstemmed | Functional Near-Infrared Spectroscopy to Probe State- and Trait-Like Conditions in Chronic Tinnitus: A Proof-of-Principle Study |
| title_short | Functional Near-Infrared Spectroscopy to Probe State- and Trait-Like Conditions in Chronic Tinnitus: A Proof-of-Principle Study |
| title_sort | functional near infrared spectroscopy to probe state and trait like conditions in chronic tinnitus a proof of principle study |
| url | http://dx.doi.org/10.1155/2014/894203 |
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