Disruption of the Serotonergic System after Neonatal Hypoxia-Ischemia in a Rodent Model
Identifying which specific neuronal phenotypes are vulnerable to neonatal hypoxia-ischemia, where in the brain they are damaged, and the mechanisms that produce neuronal losses are critical to determine the anatomical substrates responsible for neurological impairments in hypoxic-ischemic brain-inju...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2012/650382 |
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| author | Kathryn M. Buller Julie A. Wixey Hanna E. Reinebrant |
| author_facet | Kathryn M. Buller Julie A. Wixey Hanna E. Reinebrant |
| author_sort | Kathryn M. Buller |
| collection | DOAJ |
| description | Identifying which specific neuronal phenotypes are vulnerable to neonatal hypoxia-ischemia, where in the brain they are damaged, and the mechanisms that produce neuronal losses are critical to determine the anatomical substrates responsible for neurological impairments in hypoxic-ischemic brain-injured neonates. Here we describe our current work investigating how the serotonergic network in the brain is disrupted in a rodent model of preterm hypoxia-ischemia. One week after postnatal day 3 hypoxia-ischemia, losses of serotonergic raphé neurons, reductions in serotonin levels in the brain, and reduced serotonin transporter expression are evident. These changes can be prevented using two anti-inflammatory interventions; the postinsult administration of minocycline or ibuprofen. However, each drug has its own limitations and benefits for use in neonates to stem damage to the serotonergic network after hypoxia-ischemia. By understanding the fundamental mechanisms underpinning hypoxia-ischemia-induced serotonergic damage we will hopefully move closer to developing a successful clinical intervention to treat neonatal brain injury. |
| format | Article |
| id | doaj-art-28f1b0e038524d4fa3ee03f1a408a3a3 |
| institution | Kabale University |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-28f1b0e038524d4fa3ee03f1a408a3a32025-02-03T06:11:16ZengWileyNeurology Research International2090-18522090-18602012-01-01201210.1155/2012/650382650382Disruption of the Serotonergic System after Neonatal Hypoxia-Ischemia in a Rodent ModelKathryn M. Buller0Julie A. Wixey1Hanna E. Reinebrant2Royal Brisbane and Women’s Hospital, The University of Queensland, Herston, QLD 4029, AustraliaClinical Neuroscience, Perinatal Research Centre, The University of Queensland Centre for Clinical Research, Royal Brisbane and Women’s Hospital, The University of Queensland, Herston, QLD 4029, AustraliaClinical Neuroscience, Perinatal Research Centre, The University of Queensland Centre for Clinical Research, Royal Brisbane and Women’s Hospital, The University of Queensland, Herston, QLD 4029, AustraliaIdentifying which specific neuronal phenotypes are vulnerable to neonatal hypoxia-ischemia, where in the brain they are damaged, and the mechanisms that produce neuronal losses are critical to determine the anatomical substrates responsible for neurological impairments in hypoxic-ischemic brain-injured neonates. Here we describe our current work investigating how the serotonergic network in the brain is disrupted in a rodent model of preterm hypoxia-ischemia. One week after postnatal day 3 hypoxia-ischemia, losses of serotonergic raphé neurons, reductions in serotonin levels in the brain, and reduced serotonin transporter expression are evident. These changes can be prevented using two anti-inflammatory interventions; the postinsult administration of minocycline or ibuprofen. However, each drug has its own limitations and benefits for use in neonates to stem damage to the serotonergic network after hypoxia-ischemia. By understanding the fundamental mechanisms underpinning hypoxia-ischemia-induced serotonergic damage we will hopefully move closer to developing a successful clinical intervention to treat neonatal brain injury.http://dx.doi.org/10.1155/2012/650382 |
| spellingShingle | Kathryn M. Buller Julie A. Wixey Hanna E. Reinebrant Disruption of the Serotonergic System after Neonatal Hypoxia-Ischemia in a Rodent Model Neurology Research International |
| title | Disruption of the Serotonergic System after Neonatal Hypoxia-Ischemia in a Rodent Model |
| title_full | Disruption of the Serotonergic System after Neonatal Hypoxia-Ischemia in a Rodent Model |
| title_fullStr | Disruption of the Serotonergic System after Neonatal Hypoxia-Ischemia in a Rodent Model |
| title_full_unstemmed | Disruption of the Serotonergic System after Neonatal Hypoxia-Ischemia in a Rodent Model |
| title_short | Disruption of the Serotonergic System after Neonatal Hypoxia-Ischemia in a Rodent Model |
| title_sort | disruption of the serotonergic system after neonatal hypoxia ischemia in a rodent model |
| url | http://dx.doi.org/10.1155/2012/650382 |
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