Behavioral Monitoring in Transient Ischemic Attack and Stroke Patients: Exploratory Micro- and Macrostructural Imaging Insights for Identifying Post-Stroke Depression with Accelerometers in UK Biobank
To examine the association between post-stroke depression (PSD) and macrostructural and microstructural brain measures, and to explore whether changes in accelerometer-measured physical activity (PA) are associated with PSD, we conducted an exploratory study in UK Biobank with dementia-free particip...
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MDPI AG
2025-02-01
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| author | Stephanie J. Zawada Ali Ganjizadeh Bart M. Demaerschalk Bradley J. Erickson |
| author_facet | Stephanie J. Zawada Ali Ganjizadeh Bart M. Demaerschalk Bradley J. Erickson |
| author_sort | Stephanie J. Zawada |
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| description | To examine the association between post-stroke depression (PSD) and macrostructural and microstructural brain measures, and to explore whether changes in accelerometer-measured physical activity (PA) are associated with PSD, we conducted an exploratory study in UK Biobank with dementia-free participants diagnosed with at least one prior stroke. Eligible participants (<i>n</i> = 1186) completed an MRI scan. Depression was classified based on positive depression screening scores (PHQ-2 ≥ 3). Multivariate linear regression models assessed the relationships between depression and structural and diffusion measures generated from brain MRI scans. Logistic regression models were used to examine the relationship between accelerometer-measured daily PA and future depression (<i>n</i> = 367). Depression was positively associated with total white matter hyperintensities (WMHs) volume (standardized β [95% CI]—0.1339 [0.012, 0.256]; FDR-adjusted <i>p</i>-value—0.039), periventricular WMHs volume (standardized β [95% CI]—0.1351 [0.020, 0.250]; FDR-adjusted <i>p</i>-value—0.027), and reduced MD for commissural fibers (standardized β [95% CI]—−0.139 [−0.255, −0.024]; adjusted <i>p</i>-value—0.045). The odds of depression decreased by 0.3% for each daily minute spent in objectively measured light PA, while each minute spent in sleep from midnight to 6:00 AM was associated with a 0.9% decrease in the odds of depression. This early-stage analysis using a population cohort offers a scientific rationale for researchers using multimodal data sources to investigate the heterogenous nature of PSD and, potentially, identify stroke patients at risk of poor outcomes. |
| format | Article |
| id | doaj-art-28ef6e48b1e94e00ba745715bfac37f5 |
| institution | DOAJ |
| issn | 1424-8220 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
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| series | Sensors |
| spelling | doaj-art-28ef6e48b1e94e00ba745715bfac37f52025-08-20T03:12:35ZengMDPI AGSensors1424-82202025-02-0125396310.3390/s25030963Behavioral Monitoring in Transient Ischemic Attack and Stroke Patients: Exploratory Micro- and Macrostructural Imaging Insights for Identifying Post-Stroke Depression with Accelerometers in UK BiobankStephanie J. Zawada0Ali Ganjizadeh1Bart M. Demaerschalk2Bradley J. Erickson3Mayo Clinic College of Medicine and Science, Scottsdale, AZ 85054, USAMayo Clinic Artificial Intelligence Laboratory, Rochester, MN 55905, USAMayo Clinic Department of Neurology, Division of Cerebrovascular Diseases, Phoenix, AZ 85054, USAMayo Clinic Artificial Intelligence Laboratory, Rochester, MN 55905, USATo examine the association between post-stroke depression (PSD) and macrostructural and microstructural brain measures, and to explore whether changes in accelerometer-measured physical activity (PA) are associated with PSD, we conducted an exploratory study in UK Biobank with dementia-free participants diagnosed with at least one prior stroke. Eligible participants (<i>n</i> = 1186) completed an MRI scan. Depression was classified based on positive depression screening scores (PHQ-2 ≥ 3). Multivariate linear regression models assessed the relationships between depression and structural and diffusion measures generated from brain MRI scans. Logistic regression models were used to examine the relationship between accelerometer-measured daily PA and future depression (<i>n</i> = 367). Depression was positively associated with total white matter hyperintensities (WMHs) volume (standardized β [95% CI]—0.1339 [0.012, 0.256]; FDR-adjusted <i>p</i>-value—0.039), periventricular WMHs volume (standardized β [95% CI]—0.1351 [0.020, 0.250]; FDR-adjusted <i>p</i>-value—0.027), and reduced MD for commissural fibers (standardized β [95% CI]—−0.139 [−0.255, −0.024]; adjusted <i>p</i>-value—0.045). The odds of depression decreased by 0.3% for each daily minute spent in objectively measured light PA, while each minute spent in sleep from midnight to 6:00 AM was associated with a 0.9% decrease in the odds of depression. This early-stage analysis using a population cohort offers a scientific rationale for researchers using multimodal data sources to investigate the heterogenous nature of PSD and, potentially, identify stroke patients at risk of poor outcomes.https://www.mdpi.com/1424-8220/25/3/963strokeretinal artery occlusiontransient ischemic attackdepressionremote monitoringsleep |
| spellingShingle | Stephanie J. Zawada Ali Ganjizadeh Bart M. Demaerschalk Bradley J. Erickson Behavioral Monitoring in Transient Ischemic Attack and Stroke Patients: Exploratory Micro- and Macrostructural Imaging Insights for Identifying Post-Stroke Depression with Accelerometers in UK Biobank Sensors stroke retinal artery occlusion transient ischemic attack depression remote monitoring sleep |
| title | Behavioral Monitoring in Transient Ischemic Attack and Stroke Patients: Exploratory Micro- and Macrostructural Imaging Insights for Identifying Post-Stroke Depression with Accelerometers in UK Biobank |
| title_full | Behavioral Monitoring in Transient Ischemic Attack and Stroke Patients: Exploratory Micro- and Macrostructural Imaging Insights for Identifying Post-Stroke Depression with Accelerometers in UK Biobank |
| title_fullStr | Behavioral Monitoring in Transient Ischemic Attack and Stroke Patients: Exploratory Micro- and Macrostructural Imaging Insights for Identifying Post-Stroke Depression with Accelerometers in UK Biobank |
| title_full_unstemmed | Behavioral Monitoring in Transient Ischemic Attack and Stroke Patients: Exploratory Micro- and Macrostructural Imaging Insights for Identifying Post-Stroke Depression with Accelerometers in UK Biobank |
| title_short | Behavioral Monitoring in Transient Ischemic Attack and Stroke Patients: Exploratory Micro- and Macrostructural Imaging Insights for Identifying Post-Stroke Depression with Accelerometers in UK Biobank |
| title_sort | behavioral monitoring in transient ischemic attack and stroke patients exploratory micro and macrostructural imaging insights for identifying post stroke depression with accelerometers in uk biobank |
| topic | stroke retinal artery occlusion transient ischemic attack depression remote monitoring sleep |
| url | https://www.mdpi.com/1424-8220/25/3/963 |
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