Mesenchymal stromal/stem cell-derived exosomes as a potential therapeutic approach to osteoarthritis combined with type 2 diabetes mellitus
Osteoarthritis (OA) and type 2 diabetes mellitus (T2DM) often coexist due to shared risk factors and high prevalence, but effective treatment methods are currently lacking. Mesenchymal stromal/stem cell-derived exosomes (MSC-Exos) have regenerative properties that can repair cartilage damage, lower...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1549096/full |
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| author | Siyi Xie Siyi Xie Meiling Liu Meiling Liu Yajie Kong Yajie Kong Yiming Yang Ruixue Chen Yuzhong Wang Shuxing Cao Yongzhou Song Yongzhou Song Yongzhou Song |
| author_facet | Siyi Xie Siyi Xie Meiling Liu Meiling Liu Yajie Kong Yajie Kong Yiming Yang Ruixue Chen Yuzhong Wang Shuxing Cao Yongzhou Song Yongzhou Song Yongzhou Song |
| author_sort | Siyi Xie |
| collection | DOAJ |
| description | Osteoarthritis (OA) and type 2 diabetes mellitus (T2DM) often coexist due to shared risk factors and high prevalence, but effective treatment methods are currently lacking. Mesenchymal stromal/stem cell-derived exosomes (MSC-Exos) have regenerative properties that can repair cartilage damage, lower blood sugar levels, and improve pancreatic β cell function, showing great potential in tissue repair. This review primarily explores the application of MSC-Exos in the treatment of OA and T2DM, the potential mechanisms of MSC-Exos, and the therapeutic strategies of engineered exosomes. Although MSC-Exo therapy shows promising therapeutic potential, further research is needed to validate its safety and feasibility. |
| format | Article |
| id | doaj-art-28d9b2a38bc54fbca86af73b0208ff4c |
| institution | DOAJ |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-28d9b2a38bc54fbca86af73b0208ff4c2025-08-20T02:49:43ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-03-011310.3389/fcell.2025.15490961549096Mesenchymal stromal/stem cell-derived exosomes as a potential therapeutic approach to osteoarthritis combined with type 2 diabetes mellitusSiyi Xie0Siyi Xie1Meiling Liu2Meiling Liu3Yajie Kong4Yajie Kong5Yiming Yang6Ruixue Chen7Yuzhong Wang8Shuxing Cao9Yongzhou Song10Yongzhou Song11Yongzhou Song12Department of Orthopedics, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaHebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Orthopedics, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaHebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Orthopedics, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaHebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Shijiazhuang, Hebei, ChinaHebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Shijiazhuang, Hebei, ChinaHebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Orthopedics, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Orthopedics, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Orthopedics, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaHebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Shijiazhuang, Hebei, ChinaHebei Key Laboratory of Rare Disease, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaOsteoarthritis (OA) and type 2 diabetes mellitus (T2DM) often coexist due to shared risk factors and high prevalence, but effective treatment methods are currently lacking. Mesenchymal stromal/stem cell-derived exosomes (MSC-Exos) have regenerative properties that can repair cartilage damage, lower blood sugar levels, and improve pancreatic β cell function, showing great potential in tissue repair. This review primarily explores the application of MSC-Exos in the treatment of OA and T2DM, the potential mechanisms of MSC-Exos, and the therapeutic strategies of engineered exosomes. Although MSC-Exo therapy shows promising therapeutic potential, further research is needed to validate its safety and feasibility.https://www.frontiersin.org/articles/10.3389/fcell.2025.1549096/fullosteoarthritistype 2 diabetes mellitusdiabetic osteoarthritismesenchymal stromal/stem cell-derived exosomesmicroRNAsengineered exosomes |
| spellingShingle | Siyi Xie Siyi Xie Meiling Liu Meiling Liu Yajie Kong Yajie Kong Yiming Yang Ruixue Chen Yuzhong Wang Shuxing Cao Yongzhou Song Yongzhou Song Yongzhou Song Mesenchymal stromal/stem cell-derived exosomes as a potential therapeutic approach to osteoarthritis combined with type 2 diabetes mellitus Frontiers in Cell and Developmental Biology osteoarthritis type 2 diabetes mellitus diabetic osteoarthritis mesenchymal stromal/stem cell-derived exosomes microRNAs engineered exosomes |
| title | Mesenchymal stromal/stem cell-derived exosomes as a potential therapeutic approach to osteoarthritis combined with type 2 diabetes mellitus |
| title_full | Mesenchymal stromal/stem cell-derived exosomes as a potential therapeutic approach to osteoarthritis combined with type 2 diabetes mellitus |
| title_fullStr | Mesenchymal stromal/stem cell-derived exosomes as a potential therapeutic approach to osteoarthritis combined with type 2 diabetes mellitus |
| title_full_unstemmed | Mesenchymal stromal/stem cell-derived exosomes as a potential therapeutic approach to osteoarthritis combined with type 2 diabetes mellitus |
| title_short | Mesenchymal stromal/stem cell-derived exosomes as a potential therapeutic approach to osteoarthritis combined with type 2 diabetes mellitus |
| title_sort | mesenchymal stromal stem cell derived exosomes as a potential therapeutic approach to osteoarthritis combined with type 2 diabetes mellitus |
| topic | osteoarthritis type 2 diabetes mellitus diabetic osteoarthritis mesenchymal stromal/stem cell-derived exosomes microRNAs engineered exosomes |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1549096/full |
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