Annotating the microbial dark matter with HiFi-NN

Annotating the microbial dark matter with HiFi-NN

Summary: The accurate computational annotation of protein sequences with enzymatic function remains a fundamental challenge in bioinformatics. Here, we present HiFi-NN (Hierarchically-Finetuned Nearest Neighbor search) which annotates protein sequences to the 4th level of Enzyme Commission (EC) numb...

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Bibliographic Details
Main Authors: Gavin Ayres, Geraldene Munsamy, Michael Heinzinger, Noelia Ferruz, Kevin Yang, Bastiaan Bergman, Philipp Lorenz
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:iScience
Subjects:
Microbiology
Computer science
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225007412
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