A Comparative Interaction between Copper Ions with Alzheimer's β Amyloid Peptide and Human Serum Albumin
The interaction of Cu2+ with the first 16 residues of the Alzheimer's amyliod β peptide, Aβ(1–16), and human serum albumin (HSA) were studied in vitro by isothermal titration calorimetry at pH 7.2 and 310 K in aqueous solution. The solvation parameters recovered from the extended solvation mode...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2012/208641 |
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| author | G. Rezaei Behbehani L. Barzegar M. Mohebbian A. A. Saboury |
| author_facet | G. Rezaei Behbehani L. Barzegar M. Mohebbian A. A. Saboury |
| author_sort | G. Rezaei Behbehani |
| collection | DOAJ |
| description | The interaction of Cu2+ with the first 16 residues of the Alzheimer's amyliod β peptide, Aβ(1–16), and human serum albumin (HSA) were studied in vitro by isothermal titration calorimetry at pH 7.2 and 310 K in aqueous solution. The solvation parameters recovered from the extended solvation model indicate that HSA is involved in the transport of copper ion. Complexes between Aβ(1–16) and copper ions have been proposed to be an aberrant interaction in the development of Alzheimer's disease, where Cu2+ is involved in Aβ(1–16) aggregation. The indexes of stability indicate that HSA removed Cu2+ from Aβ(1–16), rapidly, decreased Cu-induced aggregation of Aβ(1–16), and reduced the toxicity of Aβ(1–16) + Cu2+ significantly. |
| format | Article |
| id | doaj-art-28bf5de54d2e487b8eb66bd29eaea1ba |
| institution | Kabale University |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-28bf5de54d2e487b8eb66bd29eaea1ba2025-02-03T05:59:38ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2012-01-01201210.1155/2012/208641208641A Comparative Interaction between Copper Ions with Alzheimer's β Amyloid Peptide and Human Serum AlbuminG. Rezaei Behbehani0L. Barzegar1M. Mohebbian2A. A. Saboury3Chemistry Department, Imam Khomeini International University, Qazvin 34149-16818, IranChemistry Department, Faculty of Science, Islamic Azad University, Takestan Branch, Takestan 34819-49479, IranChemistry Department, Imam Khomeini International University, Qazvin 34149-16818, IranInstitute of Biochemistry and Biophysics, University of Tehran, Tehran 14174, IranThe interaction of Cu2+ with the first 16 residues of the Alzheimer's amyliod β peptide, Aβ(1–16), and human serum albumin (HSA) were studied in vitro by isothermal titration calorimetry at pH 7.2 and 310 K in aqueous solution. The solvation parameters recovered from the extended solvation model indicate that HSA is involved in the transport of copper ion. Complexes between Aβ(1–16) and copper ions have been proposed to be an aberrant interaction in the development of Alzheimer's disease, where Cu2+ is involved in Aβ(1–16) aggregation. The indexes of stability indicate that HSA removed Cu2+ from Aβ(1–16), rapidly, decreased Cu-induced aggregation of Aβ(1–16), and reduced the toxicity of Aβ(1–16) + Cu2+ significantly.http://dx.doi.org/10.1155/2012/208641 |
| spellingShingle | G. Rezaei Behbehani L. Barzegar M. Mohebbian A. A. Saboury A Comparative Interaction between Copper Ions with Alzheimer's β Amyloid Peptide and Human Serum Albumin Bioinorganic Chemistry and Applications |
| title | A Comparative Interaction between Copper Ions with Alzheimer's β Amyloid Peptide and Human Serum Albumin |
| title_full | A Comparative Interaction between Copper Ions with Alzheimer's β Amyloid Peptide and Human Serum Albumin |
| title_fullStr | A Comparative Interaction between Copper Ions with Alzheimer's β Amyloid Peptide and Human Serum Albumin |
| title_full_unstemmed | A Comparative Interaction between Copper Ions with Alzheimer's β Amyloid Peptide and Human Serum Albumin |
| title_short | A Comparative Interaction between Copper Ions with Alzheimer's β Amyloid Peptide and Human Serum Albumin |
| title_sort | comparative interaction between copper ions with alzheimer s β amyloid peptide and human serum albumin |
| url | http://dx.doi.org/10.1155/2012/208641 |
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