Chronic Pain in Inflammatory Arthritis: Mechanisms, Metrology, and Emerging Targets—A Focus on the JAK-STAT Pathway
Chronic pain is nowadays considered not only the mainstay symptom of rheumatic diseases but also “a disease itself.” Pain is a multidimensional phenomenon, and in inflammatory arthritis, it derives from multiple mechanisms, involving both synovitis (release of a great number of cytokines) and periph...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/2018/8564215 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832567923403653120 |
|---|---|
| author | Fausto Salaffi Giovanni Giacobazzi Marco Di Carlo |
| author_facet | Fausto Salaffi Giovanni Giacobazzi Marco Di Carlo |
| author_sort | Fausto Salaffi |
| collection | DOAJ |
| description | Chronic pain is nowadays considered not only the mainstay symptom of rheumatic diseases but also “a disease itself.” Pain is a multidimensional phenomenon, and in inflammatory arthritis, it derives from multiple mechanisms, involving both synovitis (release of a great number of cytokines) and peripheral and central pain-processing mechanisms (sensitization). In the last years, the JAK-STAT pathway has been recognized as a pivotal component both in the inflammatory process and in pain amplification in the central nervous system. This paper provides a summary on pain in inflammatory arthritis, from pathogenesis to clinimetric instruments and treatment, with a focus on the JAK-STAT pathway. |
| format | Article |
| id | doaj-art-28b15fb11ecd4a098eb9792c3fd6d9d6 |
| institution | Kabale University |
| issn | 1203-6765 1918-1523 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pain Research and Management |
| spelling | doaj-art-28b15fb11ecd4a098eb9792c3fd6d9d62025-02-03T01:00:09ZengWileyPain Research and Management1203-67651918-15232018-01-01201810.1155/2018/85642158564215Chronic Pain in Inflammatory Arthritis: Mechanisms, Metrology, and Emerging Targets—A Focus on the JAK-STAT PathwayFausto Salaffi0Giovanni Giacobazzi1Marco Di Carlo2Rheumatology Department, Università Politecnica delle Marche, Jesi, Ancona, ItalyMedical Department, Pfizer, Rome, ItalyRheumatology Department, Università Politecnica delle Marche, Jesi, Ancona, ItalyChronic pain is nowadays considered not only the mainstay symptom of rheumatic diseases but also “a disease itself.” Pain is a multidimensional phenomenon, and in inflammatory arthritis, it derives from multiple mechanisms, involving both synovitis (release of a great number of cytokines) and peripheral and central pain-processing mechanisms (sensitization). In the last years, the JAK-STAT pathway has been recognized as a pivotal component both in the inflammatory process and in pain amplification in the central nervous system. This paper provides a summary on pain in inflammatory arthritis, from pathogenesis to clinimetric instruments and treatment, with a focus on the JAK-STAT pathway.http://dx.doi.org/10.1155/2018/8564215 |
| spellingShingle | Fausto Salaffi Giovanni Giacobazzi Marco Di Carlo Chronic Pain in Inflammatory Arthritis: Mechanisms, Metrology, and Emerging Targets—A Focus on the JAK-STAT Pathway Pain Research and Management |
| title | Chronic Pain in Inflammatory Arthritis: Mechanisms, Metrology, and Emerging Targets—A Focus on the JAK-STAT Pathway |
| title_full | Chronic Pain in Inflammatory Arthritis: Mechanisms, Metrology, and Emerging Targets—A Focus on the JAK-STAT Pathway |
| title_fullStr | Chronic Pain in Inflammatory Arthritis: Mechanisms, Metrology, and Emerging Targets—A Focus on the JAK-STAT Pathway |
| title_full_unstemmed | Chronic Pain in Inflammatory Arthritis: Mechanisms, Metrology, and Emerging Targets—A Focus on the JAK-STAT Pathway |
| title_short | Chronic Pain in Inflammatory Arthritis: Mechanisms, Metrology, and Emerging Targets—A Focus on the JAK-STAT Pathway |
| title_sort | chronic pain in inflammatory arthritis mechanisms metrology and emerging targets a focus on the jak stat pathway |
| url | http://dx.doi.org/10.1155/2018/8564215 |
| work_keys_str_mv | AT faustosalaffi chronicpainininflammatoryarthritismechanismsmetrologyandemergingtargetsafocusonthejakstatpathway AT giovannigiacobazzi chronicpainininflammatoryarthritismechanismsmetrologyandemergingtargetsafocusonthejakstatpathway AT marcodicarlo chronicpainininflammatoryarthritismechanismsmetrologyandemergingtargetsafocusonthejakstatpathway |