Race or Resource? BMI, Race, and Other Social Factors as Risk Factors for Interlimb Differences among Overweight Breast Cancer Survivors with Lymphedema
Introduction. High BMI is a risk factor for upper body breast cancer-related lymphedema (BCRL) onset. Black cancer survivors are more likely to have high BMI than White cancer survivors. While observational analyses suggest up to 2.2 times increased risk of BCRL onset for Black breast cancer survivo...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2016/8241710 |
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| author | Lorraine T. Dean Anagha Kumar Taehoon Kim Matthew Herling Justin C. Brown Zi Zhang Margaret Evangelisti Renata Hackley Jiyoung Kim Andrea Cheville Andrea B. Troxel J. Sanford Schwartz Kathryn H. Schmitz |
| author_facet | Lorraine T. Dean Anagha Kumar Taehoon Kim Matthew Herling Justin C. Brown Zi Zhang Margaret Evangelisti Renata Hackley Jiyoung Kim Andrea Cheville Andrea B. Troxel J. Sanford Schwartz Kathryn H. Schmitz |
| author_sort | Lorraine T. Dean |
| collection | DOAJ |
| description | Introduction. High BMI is a risk factor for upper body breast cancer-related lymphedema (BCRL) onset. Black cancer survivors are more likely to have high BMI than White cancer survivors. While observational analyses suggest up to 2.2 times increased risk of BCRL onset for Black breast cancer survivors, no studies have explored race or other social factors that may affect BCRL severity, operationalized by interlimb volume difference (ILD). Materials and Methods. ILD was measured by perometry for 296 overweight (25 > BMI < 50) Black (n=102) or White (n=194) breast cancer survivors (>6 months from treatment) in the WISER Survivor trial. Multivariable linear regression examined associations between social and physical factors and ILD. Results. Neither Black race (−0.26, p=0.89) nor BMI (0.22, p=0.10) was associated with ILD. Attending college (−4.89, p=0.03) was the strongest factor associated with ILD, followed by having more lymph nodes removed (4.75, p=0.01), >25% BCRL care adherence (4.10, p=0.01), and years since treatment (0.55, p<0.001). Discussion. Neither race nor BMI was associated with ILD among overweight cancer survivors. Education, a proxy for resource level, was the strongest factor associated with greater ILD. Tailoring physical activity and weight loss interventions designed to address BCRL severity by resource rather than race should be considered. |
| format | Article |
| id | doaj-art-289cb9f661a14d0f8583f8f56df43d03 |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-289cb9f661a14d0f8583f8f56df43d032025-02-03T01:21:26ZengWileyJournal of Obesity2090-07082090-07162016-01-01201610.1155/2016/82417108241710Race or Resource? BMI, Race, and Other Social Factors as Risk Factors for Interlimb Differences among Overweight Breast Cancer Survivors with LymphedemaLorraine T. Dean0Anagha Kumar1Taehoon Kim2Matthew Herling3Justin C. Brown4Zi Zhang5Margaret Evangelisti6Renata Hackley7Jiyoung Kim8Andrea Cheville9Andrea B. Troxel10J. Sanford Schwartz11Kathryn H. Schmitz12Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USAMedStar Health Research Institute and MedStar Georgetown University Hospital, Division of Biostatistics, Washington, DC 20007, USASchool of Arts & Sciences, University of Pennsylvania, Philadelphia, PA 19104, USAThe Wharton School of the University of Pennsylvania, Philadelphia, PA 19104, USAPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USAJohns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USAPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USARecruitment, Outcomes, and Assessment Resource Core, University of Pennsylvania, Philadelphia, PA 19104, USASchool of Arts & Sciences, University of Pennsylvania, Philadelphia, PA 19104, USAThe Mayo Clinic, Department of Physical Medicine and Rehabilitation, Rochester, MN 55905, USAPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USAPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USAPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USAIntroduction. High BMI is a risk factor for upper body breast cancer-related lymphedema (BCRL) onset. Black cancer survivors are more likely to have high BMI than White cancer survivors. While observational analyses suggest up to 2.2 times increased risk of BCRL onset for Black breast cancer survivors, no studies have explored race or other social factors that may affect BCRL severity, operationalized by interlimb volume difference (ILD). Materials and Methods. ILD was measured by perometry for 296 overweight (25 > BMI < 50) Black (n=102) or White (n=194) breast cancer survivors (>6 months from treatment) in the WISER Survivor trial. Multivariable linear regression examined associations between social and physical factors and ILD. Results. Neither Black race (−0.26, p=0.89) nor BMI (0.22, p=0.10) was associated with ILD. Attending college (−4.89, p=0.03) was the strongest factor associated with ILD, followed by having more lymph nodes removed (4.75, p=0.01), >25% BCRL care adherence (4.10, p=0.01), and years since treatment (0.55, p<0.001). Discussion. Neither race nor BMI was associated with ILD among overweight cancer survivors. Education, a proxy for resource level, was the strongest factor associated with greater ILD. Tailoring physical activity and weight loss interventions designed to address BCRL severity by resource rather than race should be considered.http://dx.doi.org/10.1155/2016/8241710 |
| spellingShingle | Lorraine T. Dean Anagha Kumar Taehoon Kim Matthew Herling Justin C. Brown Zi Zhang Margaret Evangelisti Renata Hackley Jiyoung Kim Andrea Cheville Andrea B. Troxel J. Sanford Schwartz Kathryn H. Schmitz Race or Resource? BMI, Race, and Other Social Factors as Risk Factors for Interlimb Differences among Overweight Breast Cancer Survivors with Lymphedema Journal of Obesity |
| title | Race or Resource? BMI, Race, and Other Social Factors as Risk Factors for Interlimb Differences among Overweight Breast Cancer Survivors with Lymphedema |
| title_full | Race or Resource? BMI, Race, and Other Social Factors as Risk Factors for Interlimb Differences among Overweight Breast Cancer Survivors with Lymphedema |
| title_fullStr | Race or Resource? BMI, Race, and Other Social Factors as Risk Factors for Interlimb Differences among Overweight Breast Cancer Survivors with Lymphedema |
| title_full_unstemmed | Race or Resource? BMI, Race, and Other Social Factors as Risk Factors for Interlimb Differences among Overweight Breast Cancer Survivors with Lymphedema |
| title_short | Race or Resource? BMI, Race, and Other Social Factors as Risk Factors for Interlimb Differences among Overweight Breast Cancer Survivors with Lymphedema |
| title_sort | race or resource bmi race and other social factors as risk factors for interlimb differences among overweight breast cancer survivors with lymphedema |
| url | http://dx.doi.org/10.1155/2016/8241710 |
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