Association of vascular endothelial growth factor B (VEGFВ) gene polymorphisms with intracranial aneurysms
Intracranial aneurysm (IA) is a complex disease resulting in subarachnoid hemorrhage (SAH) due to a rupture. The average worldwide prevalence of this disease is about 2–5 %, with 50 % of them ending in death or neurological disorders of varying severity, with a high probability of recurrence of hemo...
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Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders
2019-01-01
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| Series: | Вавиловский журнал генетики и селекции |
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| Online Access: | https://vavilov.elpub.ru/jour/article/view/1801 |
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| author | R. I. Sultanova R. I. Khusainova E. R. Lebedeva M. A. Yankina D. V. Gilev E. K. Khusnutdinova |
| author_facet | R. I. Sultanova R. I. Khusainova E. R. Lebedeva M. A. Yankina D. V. Gilev E. K. Khusnutdinova |
| author_sort | R. I. Sultanova |
| collection | DOAJ |
| description | Intracranial aneurysm (IA) is a complex disease resulting in subarachnoid hemorrhage (SAH) due to a rupture. The average worldwide prevalence of this disease is about 2–5 %, with 50 % of them ending in death or neurological disorders of varying severity, with a high probability of recurrence of hemorrhage during the frst half of the year after rupture. Subarachnoid hemorrhage is annually registered in at least 18 thousand people in Russia. Associations of polymorphic variants rs594942 and rs11603042 of the VEGFB gene in intracranial aneurysm development in the Volga-Ural region of the Russian Federation with the presence of the symptom complex of undifferentiated connective tissue dysplasia (uDST) and arterial hypertension (AH) were investigated. The C* allele rs594942 and rs11603042 of the VEGFB gene is a marker of an increased risk of IA as a whole (p = 0.025; χ2 = 5.052; OR = 1.32) in women as a whole (p = 0.001; χ2 = 10.124; OR = 1.70) and in comorbid state with uDCT (p = 0.002; χ2 = 9.501; OR = 2.34) and AG (p = 0.006; χ2 = 7.385; OR = 2.109). We found that the genotype *C*C of locus rs594942 of the VEGFB gene is a marker of an increased risk of intracranial aneurysm in general (p = 0.017; χ2 = 5.702; OR = 1.49) and among women in general (p = 0.0005; χ2 = 12.078; OR = 2.25) and with the symptomatic complex uCTD (p = 0.007; χ2 = 7.173; OR = 2.67) and AH (p = 0.010; χ2 = 6.471; OR = 2.51). We have obtained new results on the role of polymorphic variants of the VEGFB gene in the formation of intracranial aneurysm, taking into account the presence of the symptom complex uDCT and AH among the residents of the Volga-Ural region of Russia. A burdened comorbid background and the presence of undifferentiated connective tissue dysplasia and arterial hypertension can contribute to an increased risk of intracranial aneurysm, as evidenced by the results of our study. |
| format | Article |
| id | doaj-art-289a646f6e3c43a8829a3f5459eb597f |
| institution | Kabale University |
| issn | 2500-3259 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders |
| record_format | Article |
| series | Вавиловский журнал генетики и селекции |
| spelling | doaj-art-289a646f6e3c43a8829a3f5459eb597f2025-02-01T09:58:06ZengSiberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and BreedersВавиловский журнал генетики и селекции2500-32592019-01-0122899299910.18699/VJ18.442849Association of vascular endothelial growth factor B (VEGFВ) gene polymorphisms with intracranial aneurysmsR. I. Sultanova0R. I. Khusainova1E. R. Lebedeva2M. A. Yankina3D. V. Gilev4E. K. Khusnutdinova5Bashkir State University; Republican Medical Genetics CenterBashkir State University; Institute of Biochemistry and Genetics – Subdivision of the Ufa Federal Research Centre, RAS; Republican Medical Genetics CenterUral State Medical University; International Center for the Treatment of Headaches “Europe-Asia”Institute of Biochemistry and Genetics – Subdivision of the Ufa Federal Research Centre, RASUral Federal UniversityBashkir State University; Institute of Biochemistry and Genetics – Subdivision of the Ufa Federal Research Centre, RAS; Republican Medical Genetics CenterIntracranial aneurysm (IA) is a complex disease resulting in subarachnoid hemorrhage (SAH) due to a rupture. The average worldwide prevalence of this disease is about 2–5 %, with 50 % of them ending in death or neurological disorders of varying severity, with a high probability of recurrence of hemorrhage during the frst half of the year after rupture. Subarachnoid hemorrhage is annually registered in at least 18 thousand people in Russia. Associations of polymorphic variants rs594942 and rs11603042 of the VEGFB gene in intracranial aneurysm development in the Volga-Ural region of the Russian Federation with the presence of the symptom complex of undifferentiated connective tissue dysplasia (uDST) and arterial hypertension (AH) were investigated. The C* allele rs594942 and rs11603042 of the VEGFB gene is a marker of an increased risk of IA as a whole (p = 0.025; χ2 = 5.052; OR = 1.32) in women as a whole (p = 0.001; χ2 = 10.124; OR = 1.70) and in comorbid state with uDCT (p = 0.002; χ2 = 9.501; OR = 2.34) and AG (p = 0.006; χ2 = 7.385; OR = 2.109). We found that the genotype *C*C of locus rs594942 of the VEGFB gene is a marker of an increased risk of intracranial aneurysm in general (p = 0.017; χ2 = 5.702; OR = 1.49) and among women in general (p = 0.0005; χ2 = 12.078; OR = 2.25) and with the symptomatic complex uCTD (p = 0.007; χ2 = 7.173; OR = 2.67) and AH (p = 0.010; χ2 = 6.471; OR = 2.51). We have obtained new results on the role of polymorphic variants of the VEGFB gene in the formation of intracranial aneurysm, taking into account the presence of the symptom complex uDCT and AH among the residents of the Volga-Ural region of Russia. A burdened comorbid background and the presence of undifferentiated connective tissue dysplasia and arterial hypertension can contribute to an increased risk of intracranial aneurysm, as evidenced by the results of our study.https://vavilov.elpub.ru/jour/article/view/1801intracranial aneurysmvascular endothelial growth factor vegfbundifferentiated connective tissue dysplasiaarterial hypertension |
| spellingShingle | R. I. Sultanova R. I. Khusainova E. R. Lebedeva M. A. Yankina D. V. Gilev E. K. Khusnutdinova Association of vascular endothelial growth factor B (VEGFВ) gene polymorphisms with intracranial aneurysms Вавиловский журнал генетики и селекции intracranial aneurysm vascular endothelial growth factor vegfb undifferentiated connective tissue dysplasia arterial hypertension |
| title | Association of vascular endothelial growth factor B (VEGFВ) gene polymorphisms with intracranial aneurysms |
| title_full | Association of vascular endothelial growth factor B (VEGFВ) gene polymorphisms with intracranial aneurysms |
| title_fullStr | Association of vascular endothelial growth factor B (VEGFВ) gene polymorphisms with intracranial aneurysms |
| title_full_unstemmed | Association of vascular endothelial growth factor B (VEGFВ) gene polymorphisms with intracranial aneurysms |
| title_short | Association of vascular endothelial growth factor B (VEGFВ) gene polymorphisms with intracranial aneurysms |
| title_sort | association of vascular endothelial growth factor b vegfв gene polymorphisms with intracranial aneurysms |
| topic | intracranial aneurysm vascular endothelial growth factor vegfb undifferentiated connective tissue dysplasia arterial hypertension |
| url | https://vavilov.elpub.ru/jour/article/view/1801 |
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